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Exercise for Obesity

N/A

Recruiting

Led By Roeland JW Middelbeek, MD

Research Sponsored by Joslin Diabetes Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

No history of diabetes (type 1 and type 2)

Age 20-60 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline; 2 hours

Awards & highlights

Study Summary

This trial looks at how genes and small molecules in blood and fat tissue change after a workout. The findings could help explain the benefits of exercise.

Who is the study for?

This trial is for adults aged 20-60 with obesity (BMI between 30.0 and 40.0) who are generally healthy, have an HbA1c level ≤5.7%, and do not exercise frequently or have diabetes. Participants must be willing to follow the study's protocol and not take certain medications that could affect the results.Check my eligibility

What is being tested?

The study aims to observe how a single session of exercise can change gene expression and molecule levels in blood and fat tissue, helping us understand how physical activity benefits those with obesity or metabolic syndrome.See study design

What are the potential side effects?

Since this trial involves a bout of exercise, potential side effects may include typical post-exercise symptoms such as muscle soreness, fatigue, shortness of breath during exertion, dizziness or lightheadedness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have never been diagnosed with diabetes.

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I am between 20 and 60 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline; 2 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline; 2 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline; 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Metabolome in fat

Transcriptome in white adipose tissue

Secondary outcome measures

Transcriptomic changes in peripheral blood mononuclear cell in people with obesity

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Acute Bout of ExerciseExperimental Treatment1 Intervention

Exercising for 60 minutes at 55-60% of VO₂ peak

Group II: No ExerciseActive Control1 Intervention

No Exercise Session

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Massachusetts Institute of TechnologyOTHER

97 Previous Clinical Trials

12,729,971 Total Patients Enrolled

3 Trials studying Obesity

3,783 Patients Enrolled for Obesity

Joslin Diabetes CenterLead Sponsor

96 Previous Clinical Trials

26,557 Total Patients Enrolled

13 Trials studying Obesity

683 Patients Enrolled for Obesity

Roeland JW Middelbeek, MDPrincipal InvestigatorJoslin Diabetes Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do you accept individuals over the age of eighty-five to partake in this clinical trial?

"This study has set 20 to 60-year-olds as the target demographic, so 202 trials are available for younger individuals and 596 can be found that focus on older participants."

Answered by AI

How many participants is the study recruiting for its current phase?

"Affirmative. Clinicaltrials.gov has information that attests to this medical investigation being active in its recruitment efforts, first posted on May 27th 2021 and most recently updated on September 15th 2022. 16 volunteers are required at a single clinical trial site."

Answered by AI

Who meets the criteria for eligibility to participate in this research?

"This clinical trial seeks 16 volunteers with obesity between the ages of 20 and 60. Necessary criteria include strict adherence to protocol, BMI from 30.0 - 40.0 kg/m2, and a lack of prior diabetes diagnoses (type 1 or type 2)."

Answered by AI

Are there vacancies for individuals to join this clinical experimentation?

"According to clinicaltrials.gov, this trial is actively recruiting participants - the initial posting being on 5/27/2021 and the last update having been made on 9/15/2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of a Single Bout of Exercise on Transcriptomics and Metabolomics in Adipose Tissue

2021. "Effects of a Single Bout of Exercise on Transcriptomics and Metabolomics in Adipose Tissue". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04865965.

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