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Vinblastine + Bevacizumab for Brain Tumor
Study Summary
This trial is testing whether adding the drug Bevacizumab to Vinblastine helps treat children with a type of brain tumor called low grade glioma. The trial will last 68 weeks and compare children who receive just Vinblastine to those who receive both drugs.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 4 trial • 45 Patients • NCT02036424Trial Design
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- My liver functions properly.I am between 6 months and 18 years old with a Low Grade Glioma.My cancer has worsened after surgery.My child is under 6 months old.I have not used any experimental drugs before starting this study treatment.I have been on a stable or decreasing dose of corticosteroids for at least a week.My bone marrow is working well.I have a serious heart condition.I have a bone fracture that hasn't healed properly.I am currently taking certain medications.My low-grade glioma has been confirmed and tested for BRAF.I can start treatment within 14 working days after being chosen.I have not had major surgery in the last 28 days.My physical health allows me to perform daily activities.I am a sexually active teenager and agree to use two forms of birth control.I have had a serious blood clot in the past.I have an active stomach or duodenal ulcer.My neurological symptoms have been stable for at least a week.I had a medium-sized surgery within the last 2 weeks.I have not had minor surgery within the last 3 days.I currently have an ongoing infection.I haven't had any major stomach or intestine issues in the last 6 months.I have a surgical wound that hasn't healed.I have only had surgery for my tumor, no other treatments.I have a bleeding disorder that increases my risk of bleeding.My kidney function is normal.
- Group 1: Arm B
- Group 2: Arm A
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Can new participants enroll in this clinical trial at this time?
"Yes, as of right now this trial is still looking for participants. August 1st 2016 was when the study was originally posted and the 3/11/2020 date represents the most recent edit."
For what sorts of medical conditions is Bevacizumab commonly prescribed?
"Bevacizumab is a medication used to treat lymphoma and hodgkins. However, it can also be effective in managing recurrent platinum-resistant epithelial ovarian cancer, malignant neoplasms, and recurrent platinum sensitive primary peritoneal cancer."
Could you please detail the side effects of Bevacizumab?
"Although there is some clinical evidence to support the safety of Bevacizumab, it did not receive a higher score because Phase 2 trials have yet to demonstrate efficacy."
What are the most similar past studies to Bevacizumab?
"First explored in 2002 at the Canberra Hospital, bevacizumab has undergone 1071 clinical trials. Right now, there are 408 more active studies underway; a majority of these additional experiments are being conducted in Toronto, Canada."
Is this clinical trial being conducted at more than one location within the state?
"There are a number of hospitals and medical centres signed up for this clinical trial, 15 in total. These locations include The Hospital for Sick Children in Toronto, CHU du Quebec-Universite Laval in Québec, as well as The Children's Hospital of Philadelphia in Philadelphia."
What is the total number of participants enrolled in this research project?
"Yes, according to the most recent update on clinicaltrials.gov, this research is still looking for volunteers. The trial was posted on August 1st, 2016 and last updated on March 11th, 2020. They need a total of 150 individuals spread out over 15 different sites."
Are patients who are over 55 years of age eligible for this clinical trial?
"The aim of this study is to recruit paediatric patients who are between 6 months and 18 years old."
How do I sign up for the research program?
"This clinical trial is testing a new medication for glioma in patients that are between 6 months and 18 years old. A total of 150 participants are needed for the study."
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