← Back to Search

Other

SCPP Management for Spinal Cord Injury (CASPER Trial)

N/A

Recruiting

Led By Brian Kwon, MD, PhD

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Blunt (non-penetrating) spinal cord injury treated either surgically or non-surgically

Complete (AIS A) or incomplete (AIS B, C) acute traumatic spinal cord injury

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months

Awards & highlights

CASPER Trial Summary

This trial will enroll 100 patients with recent, acute spinal cord injury. A lumbar intrathecal catheter will be inserted to measure intrathecal pressure and collect cerebrospinal fluid samples. The study's primary objective is to determine the effect of maintaining a systolic cerebrospinal perfusion pressure of 65 mmHg or greater on neurological recovery in patients with acute spinal cord injury, as measured by ASIA Impairment Scale grade conversion and motor score improvement.

Who is the study for?

This trial is for adults with acute traumatic spinal cord injury from C0 to T12, treated surgically or non-surgically. Participants must have a lumbar intrathecal catheter inserted within 48 hours of injury and an initial blood sample taken within 24 hours. Excluded are those with minor motor injuries (AIS D), sensory-only deficits, penetrating injuries, other major traumas or medical conditions that could affect safety or results.Check my eligibility

What is being tested?

The study tests if managing Spinal Cord Perfusion Pressure (SCPP) at ≥65 mmHg improves neurological recovery in spinal cord injury patients. It involves monitoring SCPP via a lumbar catheter and assessing recovery using the ASIA Impairment Scale. The study also collects cerebrospinal fluid and blood samples for future biomarker research.See study design

What are the potential side effects?

Potential side effects are not explicitly listed but may include risks associated with lumbar intrathecal catheter insertion such as infection, bleeding, headache or nerve damage.

CASPER Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have had a spinal cord injury that was treated without surgery.

Select...

I have a recent spinal cord injury, either complete or incomplete.

CASPER Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) Examination

Secondary outcome measures

Levels of specific biochemical markers in CSF and Blood

Spinal Cord Perfusion Pressure (SCPP)

CASPER Trial Design

1Treatment groups

Experimental Treatment

Group I: SCP Pressure ManagementExperimental Treatment1 Intervention

Active management of Spinal Cord Perfusion Pressure (SCPP) at or above 65 mmHg.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor

1,418 Previous Clinical Trials

2,467,018 Total Patients Enrolled

Rick Hansen InstituteOTHER

9 Previous Clinical Trials

665 Total Patients Enrolled

Brian Kwon, MD, PhD4.023 ReviewsPrincipal Investigator - University of British Columbia, Faculty of Medicine

University of British Columbia

1Patient Review

I was extremely disappointed with the level of customer service. I felt as though my concerns were dismissed and that the physician only wanted to talk about his successes.

Media Library

SCPP Management (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03911492 — N/A

Spinal Cord Injury Research Study Groups: SCP Pressure Management

Spinal Cord Injury Clinical Trial 2023: SCPP Management Highlights & Side Effects. Trial Name: NCT03911492 — N/A

SCPP Management (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03911492 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many research sites have been enlisted for this trial?

"Participants of this medical experiment have the choice to enrol at Hopital Du Sacre-Coeur de Montreal in Quebec, Zuckerberg San Francisco General Hospital and Trauma Center in California, or St. Michael's Hospital in Toronto - along with 8 other locales."

Answered by AI

What is the current enrollment figure for this trial?

"The clinical trial requires a total of 100 participants who are eligible for the study. Those interested in joining can do so at Hopital Du Sacre-Coeur de Montreal located in Montreal, Quebec or Zuckerberg San Francisco General Hospital and Trauma Center situated in California's Bay Area."

Answered by AI

Are any new patients accepted for this research study at the moment?

"Affirmative. The information available on clinicaltrials.gov validates that this medical trial has begun actively recruiting participants, starting from August 31st 2019 and most recently updated on September 26th 2022. A total of 100 patients need to be recruited from 8 different healthcare facilities."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

Brian Kwon 2019. "Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03911492.

All > Spinal Cord Injury > Spinal Cord