Exercise for Men

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Men+2 MoreExercise - Other
Eligibility
18 - 40
Male
What conditions do you have?
Select

Study Summary

This trial is designed to see if epigenetic programming in sperm changes in response to diet and exercise in obese, inactive men.

Eligible Conditions
  • Men
  • Healthy Lifestyle
  • Obesity

Treatment Effectiveness

Study Objectives

3 Primary · 19 Secondary · Reporting Duration: 5 years

12-48 weeks
Changes in BMI
Changes in HDL
Changes in HbA1c
Insulin Resistance
Changes in LDL
Changes in Triglycerides
Changes in VO2peak
Glucose
Changes in insulin
Changes in muscle torque
Changes in nutrient intake
Changes in plasma cholesterol
Changes in waist/hip ratio
Changes in weight
Comparing differential sperm epigenetic signals (DNA methylation)
Comparing differential sperm epigenetic signals (histone modifications)
Comparing differential sperm epigenetic signals (non-coding RNAs)
Correlate the alternations in sperm epigenome with clinical and biochemical and "fitness" biomarker
5 years
Changes in the sperm epigenome (DNA methylation)
Changes in the sperm epigenome (Histone modifications)
Changes in the sperm epigenome (non-coding RNAs)
Diet and Exercise Modulate the Sperm Epigenome in Men

Trial Safety

Trial Design

5 Treatment Groups

Normal/Active
1 of 5
Diet
1 of 5
Diet and exercise training
1 of 5
Exercise Training
1 of 5
Obese/Inactive
1 of 5

Active Control

Experimental Treatment

Non-Treatment Group

100 Total Participants · 5 Treatment Groups

Primary Treatment: Exercise · Has Placebo Group · N/A

Diet
Other
Experimental Group · 1 Intervention: Diet · Intervention Types: Other
Diet and exercise trainingExperimental Group · 2 Interventions: Exercise, Diet · Intervention Types: Other, Other
Exercise Training
Other
Experimental Group · 1 Intervention: Exercise · Intervention Types: Other
Normal/Active
Other
ActiveComparator Group · 1 Intervention: Standard care · Intervention Types: Other
Obese/Inactive
Other
PlaceboComparator Group · 1 Intervention: Standard care · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 5 years

Who is running the clinical trial?

National Institutes of Health (NIH)NIH
2,442 Previous Clinical Trials
24,578,178 Total Patients Enrolled
1 Trials studying Men
23,188 Patients Enrolled for Men
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterLead Sponsor
96 Previous Clinical Trials
31,765 Total Patients Enrolled
1 Trials studying Men
100 Patients Enrolled for Men
Christina Wang, MDPrincipal InvestigatorThe Lundquist Institute
8 Previous Clinical Trials
523 Total Patients Enrolled

Eligibility Criteria

Age 18 - 40 · Male Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a fasting lipid panel within reference range or not clinically significant above the reference ranges.
You participate in ≤150 min/week of moderate intensity physical activity.
Consume at least 30% of your calories from fat.
You participate in ≥150 min/week of moderate intensity physical activity as assessed by accelerometer.
Consume less than 30% of calories as fat/day.