Proton Therapy vs. Photon Radiation for Prostate Cancer
(COMPPARE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes \[quality of life (QOL), toxicity, and disease control\] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is proton therapy safe for treating prostate cancer?
How does proton therapy differ from photon radiation for prostate cancer treatment?
What data supports the effectiveness of the treatment Proton Therapy vs. Photon Radiation for Prostate Cancer?
Proton therapy is known to reduce the overall radiation dose to the patient compared to photon therapy, which can be beneficial in sparing healthy tissues. However, while proton therapy shows promise, especially in reducing side effects, its cost-effectiveness and clear clinical advantage over photon therapy for prostate cancer remain uncertain.26101112
Who Is on the Research Team?
Nancy P. Mendenhall, MD
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
Men aged 30-85 with localized prostate cancer and a life expectancy of at least 8 years can join. They must have no history of invasive pelvic cancers, prior prostate cancer treatments (except certain therapies for benign conditions), or metastatic disease. Participants need to be physically able to complete the study and give informed consent.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive either proton or photon radiation therapy as part of the study
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Proton Arm 1: Standard Proton Therapy
- Proton Arm 2: Hypofractionated Proton Therapy
- Standard of Care IMRT (Photon)
- Standard of Care Proton Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
Patient-Centered Outcomes Research Institute
Collaborator