Healthy Cookies for Blood Fat Levels in Healthy Adults

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Ohio State University

Disqualifiers: Diabetes, Heart disease, Cancer, others

Compensation: Varies

Number of Visits: 1

Duration: 2 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether eating healthy cookies daily for two weeks can alter fat levels in the blood. Researchers aim to determine if these cookies can increase linoleic acid, a specific type of healthy fat, in the blood. Participants will consume either cookies high in linoleic acid or cookies high in oleic acid to compare effects. Nonsmokers without certain health conditions, such as diabetes or heart disease, and without food allergies, may be suitable for this trial. As an unphased trial, this study provides a unique opportunity to contribute to nutritional science and potentially enhance dietary recommendations.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if your medications would conflict with eating the healthy cookies.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that linoleic acid, a type of fat found in vegetable and seed oils, is generally safe for people and is a regular part of diets worldwide. Studies indicate that linoleic acid is an essential fatty acid, meaning the body needs it to function properly.

Specific safety data for the high linoleic acid healthy cookies is not available. However, since linoleic acid is commonly consumed, these cookies are likely well-tolerated.

The same applies to the high oleic acid healthy cookies. Oleic acid, another type of fat found in foods like olive oil, is widely eaten and considered safe for most people.

In summary, both types of cookies use ingredients common in everyday diets and are generally safe. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about these treatments because they offer a tasty and innovative way to manage blood fat levels using everyday snacks. Unlike traditional methods that might involve medications or dietary supplements, these cookies incorporate natural oils—linoleic acid from grapeseed oil and oleic acid from safflower oil—as active ingredients. The use of healthy cookies as a delivery method is unique, potentially making it easier for people to stick to their health routines. This approach not only aims to improve blood fat levels but also provides a more enjoyable and accessible option for maintaining healthy lipid profiles.

What evidence suggests that this trial's treatments could be effective for blood fat levels?

Studies have shown that linoleic acid, a type of healthy fat, plays a crucial role in heart health. Research indicates that increasing linoleic acid intake can lower the risk of heart disease and improve blood fat levels, which are vital for heart health. Previous studies have linked foods high in linoleic acid to healthier blood fat levels. In this trial, participants will consume High Linoleic Acid Healthy Cookies, which might help increase good fats in the blood. Another group will consume High Oleic Acid Healthy Cookies for comparison. ^{1 4 6 7 8}

Are You a Good Fit for This Trial?

This trial is for healthy adults who don't smoke and have no food or bee allergies, dietary restrictions that conflict with cookie ingredients, gastrointestinal diseases, or a history of major illnesses like diabetes, heart disease, kidney or liver issues. Pregnant individuals and those on certain medications are also excluded.

Inclusion Criteria

You do not smoke.

Exclusion Criteria

I have or had diabetes, heart, kidney, liver, circulatory diseases, or am being treated for cancer.

You are pregnant.

You have a food allergy or intolerance, and/or an allergy to bees.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume healthy cookies daily for two weeks to assess changes in blood fatty acids

2 weeks

Daily consumption, 1 visit (in-person) at the end of the phase

Follow-up

Participants are monitored for changes in blood fatty acids and other health metrics after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• High Linoleic Acid Healthy Cookies
• High Oleic Acid Healthy Cookies

Trial Overview The study aims to see if eating 'healthy cookies' rich in linoleic acid or oleic acid every day for two weeks can increase levels of these fats in the blood. It's testing whether these cookies could be beneficial for health by affecting blood fat content.

How Is the Trial Designed?

Group I: High Linoleic Acid Healthy Cookies Experimental Treatment 1 Intervention

High Linoleic Acid Healthy Cookies (10g grapeseed oil) 1 per day for 2 weeks Phase 1: N=39 adults single arm Phase 2: N=42 adults

Group II: High Oleic Acid Healthy Cookies Placebo Group 1 Intervention

High Oleic Acid Healthy Cookies (10g safflower oil) 1 per day for 2 weeks Matched for Phase 2: N=42 adults

Who Is Running the Clinical Trial?

Ohio State University

Lead Sponsor

Trials

891

Recruited

2,659,000+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10253160/

Effects of Dietary Linoleic Acid on Blood Lipid Profiles LA supplementation in an excess of 20 g/d could be an effective dose for lowering lipid profiles. The research results provide further evidence ...

2. withpower.com withpower.com/trial/phase-8-2020-b6e29

High Linoleic Acid Healthy Cookies for Healthy Adults · Info ... The hypothesis of the study is that consuming 1 healthy cookie rich in linoleic acid each day for two weeks will improve mitochondrial biology in white blood ...

3. openheart.bmj.com openheart.bmj.com/content/5/2/e000871

Effects of dietary fats on blood lipids: a review of direct ... Saturated fat has been demonised as a dietary culprit in heart disease due to its ability to raise low-density lipoprotein cholesterol (LDL-C).

4. mdpi.com mdpi.com/2304-8158/12/16/3005

Effects of Dietary Plant-Derived Low-Ratio Linoleic Acid/ ... This meta-analysis aimed to investigate the impact of low-ratio linoleic acid/alpha-linolenic acid (LA/ALA) supplementation on the blood lipid profiles in ...

5. sciencedirect.com sciencedirect.com/science/article/abs/pii/S0021915019315758

Dietary linoleic acid and human health An adequate dietary supply of LA is crucial for human health. LA intakes/blood levels are inversely correlated with cardiovascular disease risk.

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10386285/

Linoleic Acid: A Narrative Review of the Effects ... The most common source of PUFAs in the human diet today are vegetable and seed oils that contain linoleic acid (LA), which is an omega-6 fatty acid. LA is a ...

7. mdpi.com mdpi.com/2304-8158/12/11/2129

Effects of Dietary Linoleic Acid on Blood Lipid Profiles Linoleic acid (LA) is classified as an essential fatty acid for humans, and the average intake of LA in many countries around the world far exceeds the ...

8. journals.lww.com journals.lww.com/nutritiontodayonline/fulltext/9900/health_implications_of_linoleic_acid_and_seed_oil.50.aspx

Health Implications of Linoleic Acid and Seed Oil Intake Nearly 90% of dietary PUFA comprise the essential omega-6 (n-6) fatty acid linoleic acid (LA) (Table 1). ... high in this fatty acid. 9,10 ...