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40 Depression Trials near Cleveland, OH
Power is an online platform that helps thousands of Depression patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
Learn More About PowerMultiple Medications for Bipolar Depression
Trial Details
Key Eligibility Criteria
2726 Participants Needed
PATH-SS for Post-Traumatic Stress Disorder
Trial Details
Key Eligibility Criteria
45 Participants Needed
PATH vs PMR for PTSD and Depression
Trial Details
Key Eligibility Criteria
135 Participants Needed
Mindfulness-Based Intervention for Depression
Trial Details
Key Eligibility Criteria
76 Participants Needed
MBCT for Depression in Breast Cancer Survivors
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Key Eligibility Criteria
31 Participants Needed
Trial Details
Key Eligibility Criteria
82 Participants Needed
NMRA 335140 for Depression
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Key Eligibility Criteria
332 Participants Needed
ECT vs. Ketamine for Depression
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Key Eligibility Criteria
1500 Participants Needed
RE104 for Postpartum Depression
Trial Details
Key Eligibility Criteria
72 Participants Needed
Ketamine for Bipolar Depression
Trial Details
Key Eligibility Criteria
20 Participants Needed
Lurasidone for Cognitive Improvement in Bipolar Disorder
Trial Details
Key Eligibility Criteria
150 Participants Needed
Mindfulness Therapy for Migraines
Trial Details
Key Eligibility Criteria
144 Participants Needed
Pramipexole vs Escitalopram for Depression in HIV
Trial Details
Key Eligibility Criteria
186 Participants Needed
Trial Details
Key Eligibility Criteria
175 Participants Needed
AI Technology for Depression and Anxiety Detection
Trial Details
Key Eligibility Criteria
30 Participants Needed
ABX-002-2001 for Depression
Trial Details
Key Eligibility Criteria
230 Participants Needed
SP-624 for Depression
Trial Details
Key Eligibility Criteria
456 Participants Needed
Lumateperone for Pediatric Bipolar Depression
Trial Details
Key Eligibility Criteria
384 Participants Needed
Zelquistinel for Depression
Trial Details
Key Eligibility Criteria
164 Participants Needed
ALTO-203 for Depression
Trial Details
Key Eligibility Criteria
60 Participants Needed
Why Other Patients Applied
"My long history of depression has been met with a long list of trial and error drugs. My current medication (generic Pristiq) has been prescribed for two decades (though I tried several other medications during my last serious episode several years ago. When the episode passed I returned to generic Pristiq. I am interested in a clinical trial because I wonder if I can do something different to more effectively avoid a serious depressive episode and lift the general malaise I often feel."
"I've been through a substance abuse program three times. Clearly, it's not working. I need to try something totally different and new to deal with my depression (plus alcohol usage) once and for all. I did some research on psilocybin and want to try."
"Dealt with treatment-resistant depression for pretty much my entire life. I would be eternally grateful for something that actually worked for once. I'd just like to feel normal. "
"I've used SSRIs (Lexapro, Celexa) and they helped a bit but also, truthfully, they've had pretty serious sexual side effects. Depression was already hurting my marriage, and now these drugs continue to paralyze my it. I've heard that psilocybin-based treatments typically have no sexual side effects... I think a clinical trial will let me try safely."
"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."
Centanafadine for Depression
Trial Details
Key Eligibility Criteria
336 Participants Needed
VNS for Bipolar Depression
Trial Details
Key Eligibility Criteria
6800 Participants Needed
ALTO-100 for Bipolar Depression
Trial Details
Key Eligibility Criteria
200 Participants Needed
Aticaprant + Antidepressant for Depression
Trial Details
Key Eligibility Criteria
660 Participants Needed
Medical Cannabis for Chronic Pain
Trial Details
Key Eligibility Criteria
200000 Participants Needed
Seltorexant for Depression
Trial Details
Key Eligibility Criteria
752 Participants Needed
Psilocybin for Treatment-Resistant Depression
Trial Details
Key Eligibility Criteria
255 Participants Needed
Osavampator as an Adjunctive Treatment for Depression
Trial Details
Key Eligibility Criteria
200 Participants Needed
Lumateperone for Major Depressive Disorder
Trial Details
Key Eligibility Criteria
470 Participants Needed
Esketamine for Major Depressive Disorder
Trial Details
Key Eligibility Criteria
90 Participants Needed
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Frequently Asked Questions
How much do Depression clinical trials in Cleveland, OH pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
How do Depression clinical trials in Cleveland, OH work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Depression trials in Cleveland, OH 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length in Cleveland, OH for Depression is 12 months.
How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility in Cleveland, OH several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Do I need to be insured to participate in a Depression medical study in Cleveland, OH?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
What are the newest Depression clinical trials in Cleveland, OH?
Most recently, we added Pramipexole vs Escitalopram for Depression in HIV, AI Technology for Depression and Anxiety Detection and Mindfulness-Based Intervention for Depression to the Power online platform.
What are the current treatment options for depression?
Doctors use a stepped-care approach. First, most people try evidence-based talk therapy (such as CBT or interpersonal therapy), an antidepressant medicine (SSRIs are typical), or both, while also improving sleep, exercise and diet. If symptoms persist, the next “step” is to add or switch treatments—e.g., combining two medicines, adding lithium or an antipsychotic, or using brain-stimulation methods like transcranial magnetic stimulation or, for severe cases, electroconvulsive therapy; newer options such as esketamine nasal spray are reserved for treatment-resistant depression. Working with a clinician to review progress every few weeks and adjust the plan is key to finding the right mix.
When is depression considered severe?
Doctors call a depressive episode “severe” when almost all of the nine core symptoms are present at high intensity, the person’s daily life has largely shut down (can’t work, study, or manage self-care), or there are high-risk features like active suicidal thoughts, a recent attempt, or hallucinations/false beliefs. On common checklists this usually means a PHQ-9 score of 20 or higher, and it signals the need for urgent, comprehensive care—often a combination of medication, psychotherapy, and sometimes hospitalization. If you or someone you know reaches this point, treat it as an emergency and contact a mental-health professional or call/text 988 (USA) or your local crisis line right away.
Is it possible to never be depressed again?
Some people have a single episode of depression and stay well, but the risk of another episode is higher if you stop treatment too soon, have had several episodes before, or still have mild symptoms. You can greatly lower that risk by continuing the treatment that got you better for at least 6–12 months, learning relapse-prevention skills in CBT or mindfulness therapy, keeping regular sleep, exercise, and social routines, and checking in early with a professional if warning signs return. In short, there is no iron-clad guarantee you’ll never be depressed again, but staying on maintenance care and a healthy lifestyle makes long-term wellness much more likely.
What are the top 3 symptoms of depression?
Doctors look first for three core signs: 1) a low or hopeless mood that hangs around most of the day, nearly every day; 2) a marked loss of interest or pleasure in things you used to enjoy (called anhedonia); and 3) big changes in body energy—feeling drained, sleeping or eating far more or less than usual. If any of these have lasted two weeks or longer, it’s time to talk with a health professional, because other symptoms can pile on and treatment works best when started early.
Is depression a chemical imbalance?
No—depression can’t be pinned on one missing brain chemical. Research shows it arises from a mix of factors: how your brain circuits and several neurotransmitters work, your genes, long-term stress, and life circumstances all interact. Because causes differ from person to person, the most effective care is usually a combination of approaches—medication when needed, talking therapies, and lifestyle changes—worked out with your clinician.
How many people have untreatable depression?
Doctors call “untreatable” depression “treatment-resistant depression,” meaning the person has not improved after trying at least two suitable antidepressants. Large studies show this applies to roughly one-quarter to one-third of people with major depression—about 2–3 % of adults overall, or roughly 5–8 million U.S. adults in any given year. Importantly, many still respond to other options such as medication combinations, ketamine/esketamine, transcranial magnetic stimulation, or electroconvulsive therapy.
How to get out of deep depression?
Think of recovery as two tracks that run side-by-side. Track 1: get professional help right away—if you ever feel unsafe call 988 (or your local hotline), and with a clinician discuss proven treatments such as CBT, antidepressant medicine, and, when needed, newer options like ketamine, transcranial magnetic stimulation or electroconvulsive therapy. Track 2: reinforce the medical plan daily with mood-boosting basics—consistent exercise, regular sleep, balanced meals, limited alcohol or drugs, and time with supportive people—because these habits make the treatments work better and give you small, sustainable lifts while you heal.
Why is depression so hard to treat?
Depression is hard to treat because it isn’t a single disease—each person’s symptoms arise from a unique blend of brain chemistry, genetics, stress, medical issues, and life circumstances—so one-size-fits-all therapies rarely work. Without a blood test to guide choices, clinicians must try treatments sequentially, and roughly one-third of people need several steps or a combination of medication, talk therapy, lifestyle changes, or newer options like ketamine or magnetic stimulation before they feel well. The encouraging news is that persistence with a systematic plan and attention to sleep, exercise, and co-existing conditions allows most patients to eventually reach full recovery.
What are unhealthy coping mechanisms for depression?
Unhealthy coping means doing things that give quick relief but actually deepen depression—common examples include using alcohol or other drugs, overeating or not eating, oversleeping or endless screen-scrolling to avoid feelings, cutting or other self-harm, harsh self-talk and rumination, and withdrawing from friends or lashing out at them. These behaviors worsen mood, relationships, and safety; if you notice yourself relying on them, reach out to a trusted person or mental-health professional (or call your local crisis line) and ask about safer skills such as problem-solving steps, scheduled activity, or therapy.
Is it OK to have clinical depression?
Yes—having clinical depression isn’t a personal failing; it’s a common medical illness, and recognising it is the first step toward feeling better. What isn’t OK is to face it alone, because untreated depression can worsen and raise the risk of other problems, whereas most people improve with timely care such as talk therapy, medication, or a combination. If symptoms last more than two weeks or include thoughts of self-harm, book a visit with a primary-care doctor or mental-health professional and, in crisis, call 988 (U.S.) or your local emergency number—effective help and recovery are the norm when treatment is started.