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Compensation: Varies

Number of Visits: 14

48 Participants Needed

Diet Intervention for Respiratory Health
(FIRE-Diet-M Trial)

Overseen ByAgnes Yuen

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of British Columbia

Disqualifiers: Pregnancy, Uncontrolled conditions, Smoking, others

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial requires that you do not use any active medications or unprescribed supplements. If you are currently taking any, you must be willing to stop using them for 4 weeks before the study starts and for the entire duration of the study.

What data supports the effectiveness of the treatment 'Diet Intervention for Respiratory Health'?

Research suggests that dietary interventions, especially those including components of the Mediterranean diet like protein, omega-3 fatty acids, and vegetables, can improve respiratory function and quality of life in patients with chronic respiratory diseases such as COPD. However, more long-term studies are needed to fully understand their effects.¹ ² ³ ⁴ ⁵

Is the diet intervention for respiratory health safe for humans?

Research suggests that dietary interventions, especially those including components of the Mediterranean diet like protein, omega-3 fatty acids, and vegetables, are generally safe and may have beneficial effects on respiratory health. However, more long-term studies are needed to fully understand their safety and effects.⁴ ⁵ ⁶ ⁷ ⁸

How does the diet intervention treatment for respiratory health differ from other treatments?

This diet intervention is unique because it focuses on improving respiratory health through a diet rich in fruits, vegetables, and n-3 fatty acids, which are believed to enhance lung function and reduce respiratory symptoms by providing antioxidants and anti-inflammatory nutrients. Unlike traditional treatments that may rely on medication, this approach uses dietary changes to potentially prevent or alleviate conditions like asthma and COPD.⁶ ⁹ ¹⁰ ¹¹ ¹²

What is the purpose of this trial?

Research suggests that consuming more fatty fish, fruits, and vegetables could potentially shield the lungs from the negative impacts of air pollution. The research team will look at whether a dietary intervention aimed at increasing intake of these foods can protect the lungs from woodsmoke as the air pollutant and look into how this works.

Research Team

Emily Brigham, MD

Principal Investigator

University of British Columbia

Eligibility Criteria

This trial is for healthy individuals interested in seeing if certain foods can protect their lungs from woodsmoke, a common air pollutant. The specific eligibility criteria to join the study have not been provided.

Inclusion Criteria

I do not use supplements, or I am willing to stop using them for the study.

Must currently consume, on average, less than 2 servings of fish per week and fewer than 5 servings of fruits and vegetables per day

My blood test shows I have a null GSTM1 genotype.

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Exclusion Criteria

Pregnant or planning to become pregnant during the study period

Health conditions that would pose an unacceptable risk of dietary change, or conditions that are uncontrolled based on principal investigator's judgement

Actively attempting to lose weight

See 3 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

1 visit (in-person)

Dietary Intervention

Participants follow either the Intervention Diet or Control Diet for approximately 4 weeks, followed by a washout period and then switch diets for another 4 weeks.

12 weeks

10 visits (in-person), weekly calls with dietician

Exposure and Assessment

Participants undergo controlled wood smoke exposure and complete outcome assessments including questionnaires, sample collections, and lung function tests.

Throughout the study

3 exposure visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the dietary intervention and exposure phases.

4 weeks

Treatment Details

Interventions

Control Diet
Intervention Diet

Trial Overview The FIRE-Diet study tests whether eating more fatty fish, fruits, and vegetables can shield lungs from woodsmoke's harmful effects. Participants will follow either their usual diet (control) or the intervention diet rich in these foods.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Intervention Diet First, then Control DietExperimental Treatment2 Interventions

Participants will complete \~4 weeks of the Intervention Diet, followed by a washout period of at least 4 weeks, then \~4 weeks of the Control Diet. At the end of each Diet period, participants will undergo a 2 hour controlled wood smoke exposure, following which outcome measures will be assessed.

Group II: Control Diet First, then Intervention DietExperimental Treatment2 Interventions

Participants will complete \~4 weeks of the Control Diet, followed by a washout period of at least 4 weeks, then \~4 weeks of the Intervention Diet. At the end of each Diet period, participants will undergo a 2 hour controlled wood smoke exposure, following which outcome measures will be assessed.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of British Columbia

Lead Sponsor

Trials

1,506

Recruited

2,528,000+

Findings from Research

This systematic review aims to evaluate the relationship between dietary intake and asthma risk in both children and adults, following PRISMA guidelines and utilizing a comprehensive approach to analyze recent epidemiological studies.

The results of this review will contribute to evidence-based clinical practice guidelines on lifestyle interventions for managing asthma, potentially influencing dietary recommendations for asthma prevention.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Dietary intake and risk of asthma in children and adults: protocol for a systematic review and meta-analysis.Garcia-Larsen, V., Del Giacco, SR., Moreira, A., et al.[2020]