Diet Intervention for Respiratory Health
(FIRE-Diet-M Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if increasing the intake of fatty fish, fruits, and vegetables can protect the lungs from the harmful effects of woodsmoke, a common air pollutant. Participants will follow a special diet, known as the Intervention Diet, to assess its impact on lung health when exposed to woodsmoke. Individuals without lung issues, who consume less than two servings of fish and five servings of fruits and vegetables daily, and possess a specific gene type (null GSTM1 genotype) may be suitable for this study. As an unphased trial, this study provides a unique opportunity to contribute to understanding the potential health benefits of dietary changes.
Will I have to stop taking my current medications?
The trial requires that you do not use any active medications or unprescribed supplements. If you are currently taking any, you must be willing to stop using them for 4 weeks before the study starts and for the entire duration of the study.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that eating more fatty fish, fruits, and vegetables might help protect lungs from air pollution. This dietary approach is known as the "Intervention Diet." Although clinical trials have not provided specific safety data for this diet, the included foods are generally safe and part of many healthy diets.
The study is marked as "Not Applicable" for trial phases, indicating it focuses on a lifestyle change rather than a new drug. Therefore, it does not require the same rigorous safety tests as new medications. In simple terms, increasing the intake of fruits, vegetables, and fatty fish is usually safe for most people and unlikely to cause harm. However, personal allergies or dietary restrictions should always be considered.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how diet can influence respiratory health, particularly in response to wood smoke exposure. Unlike typical treatments for respiratory issues, which often rely on medications like bronchodilators and corticosteroids, this approach investigates whether dietary changes can offer protective benefits. The unique aspect of this trial is its focus on the potential for diet to modulate respiratory response, providing a non-pharmaceutical method that could complement or even reduce the need for traditional medications. This could lead to more holistic and accessible options for managing respiratory health.
What evidence suggests that this dietary intervention could be effective for respiratory health?
This trial will compare the effects of an Intervention Diet with a Control Diet on respiratory health. Research suggests that increasing fruit and vegetable intake can improve lung health over time, particularly for individuals with conditions like COPD, a lung disease that makes breathing difficult. While not all research has focused specifically on lung health, some studies indicate that better nutrition can benefit the lungs. Consuming more fatty fish, fruits, and vegetables may protect the lungs from damage caused by air pollution. These foods contain nutrients that can reduce inflammation and support lung function. Although more research is needed on the effects of air pollution, improving diet shows promise for better lung health based on its positive effects in other areas.678910
Who Is on the Research Team?
Emily Brigham, MD
Principal Investigator
University of British Columbia
Are You a Good Fit for This Trial?
This trial is for healthy individuals interested in seeing if certain foods can protect their lungs from woodsmoke, a common air pollutant. The specific eligibility criteria to join the study have not been provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dietary Intervention
Participants follow either the Intervention Diet or Control Diet for approximately 4 weeks, followed by a washout period and then switch diets for another 4 weeks.
Exposure and Assessment
Participants undergo controlled wood smoke exposure and complete outcome assessments including questionnaires, sample collections, and lung function tests.
Follow-up
Participants are monitored for safety and effectiveness after the dietary intervention and exposure phases.
What Are the Treatments Tested in This Trial?
Interventions
- Control Diet
- Intervention Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor