This trial is evaluating whether HLA-matched VSTs will improve 2 primary outcomes in patients with Infections. Measurement will happen over the course of 6 weeks.
This trial requires 47 total participants across 1 different treatment group
This trial involves a single treatment. HLA-matched VSTs is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"Infections are one of the most common causes of death among patients with hematologic cancers, and the cause of death can be directly related to the type of treatment given. There are many possible causes of infection, and in each patient with leukemia, an assessment by a hematologist or oncologist should be obtained if an infection is identified. An antibiotic prescription is recommended, and consideration should be given to instituting an infected blood-products protocol as a method of decreasing infections in patients receiving chemotherapy. The Infectious Diseases Society of America has published guidelines on prudent use of antibiotics and prudent use of blood products. These guidelines should be used in all patients with hematologic malignancies." - Anonymous Online Contributor
"The symptoms of an infection range widely and include fever, headache, muscle aches, and tiredness. The main symptoms for pneumonia and acute upper respiratory infections are fever, coughing, shortness of breath, and feeling unwell. Fever is a symptom of many infections and may be the first symptom to appear. Other features of infections may include a runny nose and an increased temperature. It may then take 6 to 10 days for the temperature to return to normal." - Anonymous Online Contributor
"It is important to consider that the presence of serious illness, or pre-existing conditions will likely exacerbate the extent to which infection contributes to symptom intensity. Common treatments for infection are antibiotics, anti-neurons, or prophylactic antibiotics. Also, prophylactic antibiotics have been shown to be effective in some cases of infectious mononucleosis (IM)." - Anonymous Online Contributor
"Infections are diseases caused by the presence of pathogenic organisms in the body; more specifically, by specific diseases caused by pathogenic bacteria. The infectious agents are spread by the direct action of these pathogens on their host's bodily membranes or through inanimate material transfer. They are also caused by viruses, prion diseases, toxins, or any other pathogenic agents or agents of chemical origin such as medications. There are many different types of infections and they differ from each other depending on the type of organism involved. Understanding infections might enable doctors to prevent or treat a wide spectrum of infectious diseases in humans and other vertebrates - a process known as nosocomial infections." - Anonymous Online Contributor
"About 8.9 million people get infections the U.S. A year. The majority of cases are acquired in homes, workplaces and in public places. The most common infections include influenza, chicken pox, mononucleosis, and ear, nose and throat infections. Infections occur during childhood and are usually well-controlled with vaccines and antibiotics. Infection-associated deaths are declining and represent some of the few instances in which they may be prevented completely." - Anonymous Online Contributor
"The use of a hlamatched donor vst resulted in lower morbidity and mortality in both the heart and lung, compared with conventional vsts. In a recent study, findings support the inclusion of grafts from HLA-matched donors in transplantation programs." - Anonymous Online Contributor
"In this large national sample of pediatric IBD patients, most patients, including adults, were already treated in clinical trials. IBD patients' willingness to use clinical trials for infections was much higher than in the general population." - Anonymous Online Contributor
"Compared with hla-matched vsts, mvsts were not associated with lower survival rates and no difference in treatment failures. Therefore, mvsts can be used in combination with other treatments. However, a meta-analysis of trials was not able to reveal whether this treatment approach improved survival. It is important to note that most MVA combinations are still investigational, so they are not yet well established as treatment regimens for SLE. Future studies should address the use of these treatments in SLE." - Anonymous Online Contributor
"Hla-matched donors/recipients have higher risk of transfemorally transmitted infections than B+ donors/recipients. HLA typing is recommended prior to the donation of HLA-matched blood and deferral from blood donation could be a solution to this problem, but prospective randomized proof of this solution is lacking." - Anonymous Online Contributor
"To keep a good quality of life and be a productive member of society, we want to learn more about the effects of infections on our functioning." - Anonymous Online Contributor
"In the past 5 years, more than 50 clinical trials examining treatments and/or vaccines for prevention of infections have been completed; however, there are many other conditions, including urinary-tract infections, sepsis, pneumonia, cellulitis, pelvic inflammatory disease, urinary, and lower-respiratory infections, and meningitis that have or might have been included in future clinical trials." - Anonymous Online Contributor