D-0120 + Allopurinol for Gout
Trial Summary
What is the purpose of this trial?
D-0120 is being tested in combination with Allopurinol in adult subjects with Gout.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, since the trial involves testing a new drug with Allopurinol, it's best to discuss your current medications with the study team.
What data supports the effectiveness of the drug Allopurinol for treating gout?
Is the combination of D-0120 and Allopurinol safe for humans?
What makes the drug D-0120 + Allopurinol unique for treating gout?
The combination of D-0120 and Allopurinol for treating gout is unique because it potentially offers a novel approach by combining two agents, which may enhance the uric acid-lowering effects compared to Allopurinol alone. This could be particularly beneficial for patients who do not respond adequately to standard Allopurinol treatment.1241011
Research Team
Kathryn Stazzone
Principal Investigator
InventisBio Co., Ltd
Eligibility Criteria
Adults with gout who've had at least 2 flares in the past year can join this trial. They need to have a BMI between 18 and 40, respond poorly to urate-lowering treatments, and pass certain lab tests. Participants must not be pregnant or breastfeeding, have serious other illnesses, recent cancer history, or any condition that could risk their safety or affect study results.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive D-0120 in combination with Allopurinol. Cohort A: week 1 low dose, weeks 2-12 increased dose. Cohort B: week 1 low dose, week 2 increased dose, weeks 3-12 high dose.
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Allopurinol
- D-0120
Allopurinol is already approved in United States, European Union, Canada, Japan for the following indications:
- Gout
- Kidney stones
- High uric acid levels after chemotherapy
- Gout
- Kidney stones
- High uric acid levels after chemotherapy
- Gout
- Kidney stones
- High uric acid levels after chemotherapy
- Gout
- Kidney stones
- High uric acid levels after chemotherapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
InventisBio Co., Ltd
Lead Sponsor