VB10.NEO + Atezolizumab for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a new cancer vaccine combined with a drug that helps the immune system in patients whose cancer has not responded to usual treatments. The vaccine helps the immune system recognize cancer cells, and the drug boosts the immune response to attack these cells more effectively.
Who Is on the Research Team?
Siri Torhaug, MD
Principal Investigator
Nykode Therapeutics ASA
Are You a Good Fit for This Trial?
Adults with advanced solid tumors that have worsened after standard therapy or for whom standard therapy isn't suitable. Participants must be expected to live at least 6 months, have good organ function, and an ECOG Performance Status of 0 or 1. They should not be pregnant or breastfeeding and must agree to use effective contraception.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive VB10.NEO in combination with Atezolizumab. VB10.NEO is administered by IM injection for an induction course Q3W (4 doses) followed by maintenance doses Q6W (6 doses) and Q12W (5 doses). Atezolizumab is administered by IV infusion on Day 1 of 21-day cycles.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including changes in vital signs and clinical laboratory parameters.
Open-label extension (optional)
Participants may opt into continuation of treatment long-term to further assess safety and efficacy.
What Are the Treatments Tested in This Trial?
Interventions
- VB10.NEO
Find a Clinic Near You
Who Is Running the Clinical Trial?
Nykode Therapeutics AS
Lead Sponsor
Nykode Therapeutics ASA
Lead Sponsor
Genentech, Inc.
Industry Sponsor
Ashley Magargee
Genentech, Inc.
Chief Executive Officer since 2024
MBA from Harvard University, BA from Princeton University
Levi Garraway
Genentech, Inc.
Chief Medical Officer since 2021
MD, PhD
Vaccibody AS
Industry Sponsor