Brain Stimulation for PTSD
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to develop and test a novel pathophysiology of PTSD by integrating sensory cortical (SC) and amygdala-PFC dysfunctions into a tripartite Sensory-Prefrontal-Cortex-Amygdala (SPA) model.
Will I have to stop taking my current medications?
If you are taking calcium channel blockers or alpha-blockers, you will need to stop these medications for 48 hours before the scan. For other medications, the protocol does not specify, but you should have medication stability for the past 2 months if you are taking psychotropic medications.
Is brain stimulation using tRNS and tACS safe for humans?
Transcranial random noise stimulation (tRNS) and transcranial alternating current stimulation (tACS) are non-invasive brain stimulation methods that have been used in studies on human brain function and behavior. These methods are generally considered safe, as they involve low-intensity electrical currents and have been used in various research settings without significant safety concerns.12345
How does the treatment alpha-frequency tACS differ from other treatments for PTSD?
Alpha-frequency tACS is unique because it uses electrical currents to enhance brain wave patterns, specifically alpha oscillations, which are linked to relaxation and reduced anxiety. This non-invasive treatment can increase connectivity in the brain and reduce symptoms of anxiety, offering a novel approach compared to traditional PTSD treatments like medication or talk therapy.14678
What data supports the effectiveness of the treatment alpha-frequency tACS for PTSD?
Who Is on the Research Team?
Wen Li, PhD
Principal Investigator
Florida State University
Are You a Good Fit for This Trial?
This trial is for right-handed individuals aged 18-50 with normal vision and smell, who meet specific safety criteria. Participants must have a PTSD diagnosis and if on psychotropic meds, they should be stable for the last 2 months. Substance users must abstain for 48 hours before the experiment.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive tACS or RNS stimulation and undergo EEG-fMRI recordings
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- alpha-frequency tACS
- Random noise stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Florida State University
Lead Sponsor