Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease
CG
Overseen ByCarol Gunnoud
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase < 1
Waitlist Available
Sponsor: Yale University
No Placebo Group
Trial Summary
What is the purpose of this trial?
This trial measures microglial activity in Alzheimer's patients and compares it to healthy older adults. It aims to understand why some people with brain changes typical of Alzheimer's develop dementia while others do not. Microglia are brain cells that help with immune responses, and their activity might be linked to Alzheimer's symptoms.
Research Team
AM
Adam Mecca, M.D., Ph.D.
Principal Investigator
Yale University
Eligibility Criteria
Inclusion Criteria
National Institute on Aging (NIA)-Alzheimer's Association core clinical criteria for probable AD
Age between 55 and 90 (inclusive)
Score on the Montreal Cognitive Assessment (MOCA) greater than or equal to 17
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Treatment Details
Interventions
- Lipopolysaccharide (Other)
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Patients receiving endotoxinExperimental Treatment1 Intervention
The 20 enrolled subjects will have LPS (0.4 ng/kg) administered intravenously
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Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
Trials
1,963
Recruited
3,046,000+
National Institute on Aging (NIA)
Collaborator
Trials
1,841
Recruited
28,150,000+