Visicol

Constipation, Hypophosphatemia, Parenteral Nutrition, Total + 4 more

Treatment

1 FDA approval

20 Active Studies for Visicol

What is Visicol

Sodium phosphate, dibasic

The Generic name of this drug

Treatment Summary

Sodium phosphate is a type of medication that helps to stimulate a bowel movement by increasing fluid in the small intestine. It usually takes between 30 minutes and 6 hours for the laxative to work.

K Phos Neutral

is the brand name

image of different drug pills on a surface

Visicol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

K Phos Neutral

Sodium phosphate, dibasic

1977

15

Approved as Treatment by the FDA

Sodium phosphate, dibasic, also known as K Phos Neutral, is approved by the FDA for 1 uses which include Parenteral Nutrition, Total .

Parenteral Nutrition, Total

Effectiveness

How Visicol Affects Patients

Sodium phosphate makes stools softer and easier to pass through the large intestine.

How Visicol works in the body

Sodium phosphate is believed to work by adding more substances to the intestines, which causes an imbalance of water in the intestine. This imbalance draws in more water, creating a gradient that helps speed up the intestines.

When to interrupt dosage

The prescribed dosage of Visicol is contingent upon the indicated condition, including fluid and electrolyte upkeep treatment, Fluid substitution therapy and Irrigation. The quantity of dosage is subject to the technique of administration (e.g. Liquid or Tablet, coated) laid out in the table below.

Condition

Dosage

Administration

Hypophosphatemia

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

Parenteral Nutrition, Total

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

Bowel preparation therapy

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

Colonoscopy

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

Surgical Procedures

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

severe constipation

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

Constipation

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Intravenous, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Irrigant - Irrigation, Irrigation, Liquid, Solution, Topical, Solution - Intravenous, Tablet - Oral, Tablet, Injection, solution, Solution - Oral, Liquid - Irrigation, Tablet, coated - Oral, Tablet, coated, Injection, solution - Intravenous, Liquid - Oral, Rectal, Enema, Enema - Rectal, Injection, Irrigant, Injection - Intravenous, Solution - Irrigation, Kit, Intraocular, Kit; Solution - Intraocular; Irrigation, Intraocular; Irrigation, Kit; Solution - Intraocular, Kit; Solution, Powder - Oral, Powder, Powder, for solution, Liquid - Buccal, Spray, Buccal, Respiratory (inhalation), Tablet, effervescent, Spray - Buccal, Liquid - Topical, Solution - Respiratory (inhalation), Powder, for solution - Intraocular

Warnings

Visicol has four contraindications and should not be used in coordination with the conditions given in the following table.

There are 20 known major drug interactions with Visicol.

Common Visicol Drug Interactions

Drug Name

Risk Level

Description

Alloin

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Alloin.

Calcium polycarbophil

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Calcium polycarbophil.

Chlorpropamide

Minor

Sodium phosphate, dibasic may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.

Frangula purshiana bark

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Frangula purshiana bark.

Konjac mannan

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Konjac mannan.

Visicol Toxicity & Overdose Risk

Rats have a lethal dose of sodium phosphate of 250mg/kg when given intramuscularly and 8290mg/kg when given orally. High levels of phosphate in the body can cause tetany, dehydration, low blood pressure, rapid heartbeat, extreme fever, and even coma. Smaller patients are more at risk for experiencing phosphate toxicity.

image of a doctor in a lab doing drug, clinical research

Visicol Novel Uses: Which Conditions Have a Clinical Trial Featuring Visicol?

54 active clinical trials are ongoing to investigate the efficacy of Visicol in providing Electrolyte replacement, proctoscopy and Irrigation for treatment of certain conditions.

Condition

Clinical Trials

Trial Phases

severe constipation

0 Actively Recruiting

Bowel preparation therapy

0 Actively Recruiting

Colonoscopy

3 Actively Recruiting

Not Applicable

Constipation

18 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1

Surgical Procedures

0 Actively Recruiting

Hypophosphatemia

0 Actively Recruiting

Parenteral Nutrition, Total

0 Actively Recruiting

Visicol Reviews: What are patients saying about Visicol?

5

Patient Review

1/2/2009

Visicol for Emptying of the Bowel

Easy to use, and the pills went down easily. I was worried about taking so many at once, but it wasn't a problem.

4

Patient Review

11/30/2007

Visicol for Emptying of the Bowel

I experienced an irregular heartbeat and low potassium levels in my blood.

2

Patient Review

3/20/2009

Visicol for Emptying of the Bowel

Unfortunately, this caused me a lot of pain and vomiting. I'm still dealing with the after-effects weeks later.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about visicol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Visicol used for?

"The VISICOL colonoscopy prep medication is only to be used by adults aged 18 and over. It works by causing diarrhea, which in turn cleans out the colon before the procedure. This is important because it allows your doctor to get a better view of the inside of the colon."

Answered by AI

Is Visicol still on the market?

"This product is no longer available under the Visicol name. If the FDA has approved generic versions of this product, there may be generic equivalents available."

Answered by AI

Clinical Trials for Visicol

Image of Lindenwood University in Saint Charles, United States.

Weizmannia Coagulans for Gut Health

18 - 50
All Sexes
Saint Charles, MO

This study will evaluate the effects of supplementation with Weizmannia (Bacillus) coagulans JBI-YZ6.3 on gastrointestinal health in healthy, physically active adults. The primary objective is to determine whether daily intake of this probiotic strain improves symptoms of constipation and related gastrointestinal function compared with placebo. Approximately 30 healthy men and women aged 18 to 50 years will be enrolled in a randomized, double-blind, placebo-controlled, crossover trial. Participants will complete two 4-week supplementation periods, one with Weizmannia (Bacillus) coagulans JBI-YZ6.3 and one with placebo, separated by a 4-week washout period. The total duration of participation will be approximately 13 to 14 weeks, including screening and testing visits. Gastrointestinal symptoms will be assessed at baseline and after each supplementation period using validated questionnaires, with particular focus on the constipation domain of the Gastrointestinal Symptom Rating Scale (GSRS). Secondary outcomes will include additional gastrointestinal symptom domains and markers of perceived gut comfort and function. This study is designed to determine whether supplementation with Weizmannia (Bacillus) coagulans JBI-YZ6.3 produces clinically meaningful improvements in gastrointestinal symptoms in physically active adults compared with placebo.

Recruiting
Paid Trial

Lindenwood University

Chad M Kerksick, PhD

Image of Banner - University Medical Center South in Tucson, United States.

Dexmedetomidine + Dexamethasone for Postoperative Pain

18 - 75
All Sexes
Tucson, AZ

The goal of this clinical study is to improve upon the standard practice of utilizing nerve blocks to enhance the satisfaction of patients undergoing shoulder, or foot and ankle surgery regarding their quality of pain control, the duration of their nerve blocks, as well as the avoidance of opioid medications and subsequently their undesirable side effects. The researchers hypothesize that dexmedetomidine and dexamethasone (Dex-Dex) will work synergistically as adjuncts in a low, non-weight based formula. This would allow the investigators to improve patient satisfaction by providing them with a superior means of pain control that is longer in duration with a decreased probability of unwanted side effects. The proposed clinical study will be a prospective, randomized control trial.

Phase 1 & 2
Waitlist Available

Banner - University Medical Center South

Ronald Tang, MD

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Kiwifruit Extract for Constipation in Children

4 - 17
All Sexes
Hamilton, Canada

The goal of this pilot feasibility randomized controlled trial is to determine whether Actazin (kiwifruit extract) is a feasible and effective alternative to polyethylene glycol 3350 (PEG 3350) for maintenance therapy in children with functional constipation (FC). This study will include children aged 4 to 17 years who meet the Rome IV criteria for functional constipation. The main questions it aims to answer are: 1. Is it feasible to conduct a definitive, multi-centre trial comparing Actazin to PEG 3350 in children with FC? 2. What are the within-group differences in clinical outcomes such as stool frequency, abdominal pain, and laxative use over a 4-week period? Researchers will compare chewable Actazin tablets with placebo PEG 3350 powder to PEG 3350 powder with placebo Actazin tablets to see if Actazin is a viable non-pharmacologic natural health product alternative for treating FC. Participants will: Undergo an initial bowel cleanout using PEG 3350 and bisacodyl. Following, they will be randomized to one of two groups: 1. Actazin chewable tablets (titrate to effect: 600-2400 mg/day) + placebo PEG 3350 2. PEG 3350 (dose based on age and titratable to effect) + placebo Actazin chewable tablets Participants will take the assigned intervention daily for 4 weeks and complete a daily bowel diary recording stool frequency, consistency (Bristol Stool Scale), abdominal pain, and laxative use. They will have weekly follow-ups via phone or electronic survey to assess adherence, medication use, and adverse events. Additionally, a bi-weekly follow-up will be conducted for an additional 8 weeks to track longer-term outcomes. Outcomes: Primary feasibility outcomes include consent rate, adherence to allocated intervention, and 4-week follow-up completion rate. Secondary clinical outcomes include resolution of FC (Rome IV criteria), weekly stool frequency, abdominal pain episodes, use of rescue laxatives, and treatment palatability. This study is being conducted at McMaster Children's Hospital and is funded by the Hamilton Academic Health Sciences Organization (HAHSO). Data collection will be managed using the Lumedi™ platform, and safety will be overseen by a Data Safety Monitoring Board (DSMB).

Phase 2 & 3
Waitlist Available

Hamilton Health Sciences

Elyanne Ratcliffe, MD

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AI-Assisted Colonoscopy for Polyp Detection

18+
All Sexes
Chicago, IL

Based on prior studies, trainee and practicing gastroenterologists miss pre-cancerous polyps (adenomas and serrated polyps) during colonoscopy. The use of computer-aided detection (CADe) systems, a form of artificial intelligence (AI) has been shown to help identify colorectal lesions for practicing gastroenterologists. However, less is known how AI impacts polyp detection for trainees. The investigators are conducting a tandem colonoscopy study wherein a portion of the colon is examined first by the trainee and then the attending physician. For each procedure, randomization will occur which will determine whether or not the trainee will utilize AI for their examination of the colon. At the end of the study, the investigators will determine whether AI helps trainees miss fewer polyps during colonoscopy. The investigators will also conduct interviews with trainees to understand how AI impacts colonoscopy training.

Recruiting
Has No Placebo

Northwestern Memorial Hospital

Rajesh Keswani, MD

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