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What is Boniva
IbandronateThe Generic name of this drug
Treatment SummaryIbandronate, also known as BM 21.0955, is a type of medication used to prevent and treat bone loss in postmenopausal women. It is a third-generation drug that is similar to zoledronic acid, minodronic acid and risedronic acid. Ibandronate has been used to treat bone loss in dogs since 1993, and it was approved by the FDA in 2003.
Bonivais the brand name
Boniva Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Boniva
Ibandronate
2005
24
Approved as Treatment by the FDA
Ibandronate, otherwise known as Boniva, is approved by the FDA for 1 uses which include Osteoporosis .Osteoporosis
Helps manage Osteoporosis
Effectiveness
How Boniva Affects PatientsIbandronate is a medicine used to help prevent and treat osteoporosis in postmenopausal women. It is a relatively safe drug, and its effects can last a long time. Patients should be aware of the potential side effects such as stomach issues, low calcium, muscle pain, jaw damage, and kidney problems.
How Boniva works in the bodyBisphosphonates are taken into the body, where they bind to bone. This triggers the osteoclasts (cells that break down bone) to become acidic. This causes the bisphosphonates to be released from the bone and taken up by the osteoclasts. The bisphosphonates stop the osteoclasts from doing their job, which stops the bone from being broken down. Nitrogen containing bisphosphonates such as ibandronate also inhibit proteins that are important for cell survival. Without these proteins, cells die, causing tumor cells to die as well.
When to interrupt dosage
The advocated dosage of Boniva is contingent upon the diagnosed condition, including Bone Metastases, Malignant Neoplasms and Osteoporosis. The dose also fluctuates as per the method of delivery outlined in the table below.Condition
Dosage
Administration
Osteoporosis
, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Malignant Neoplasms
, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Bone Metastases
, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Breast Cancer
, 3.0 mg/mL, 150.0 mg, 1.0 mg, 3.0 mg, 50.0 mg, 2.0 mg, 6.0 mg, 2.5 mg, 1.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Warnings
Boniva ContraindicationsCondition
Risk Level
Notes
Esophageal Strictures
Do Not Combine
Hypocalcemia
Do Not Combine
Esophagus
Do Not Combine
Achalasia, Esophageal
Do Not Combine
Inability to sit or stand upright for at least 60 minutes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ibandronate may interact with Pulse Frequency
Common Boniva Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Ziprasidone.
Abexinostat
Minor
The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Abexinostat.
Aceprometazine
Minor
The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Aceprometazine.
Boniva Toxicity & Overdose RiskSigns of ibandronate overdose include low calcium and phosphorus levels, stomach pain, indigestion, esophagitis, and ulcers. To reduce the amount of unabsorbed drug, patients can drink milk or take antacids. Treatment for an ibandronate overdose includes providing intravenous electrolytes, and dialysis is not known to be effective in removing the drug from the bloodstream.
Boniva Novel Uses: Which Conditions Have a Clinical Trial Featuring Boniva?
At present, 729 active clinical trials are underway to ascertain the effectiveness of Boniva in ameliorating Bone Metastases, Malignant Neoplasms and Osteoporosis.Condition
Clinical Trials
Trial Phases
Malignant Neoplasms
0 Actively Recruiting
Osteoporosis
39 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Breast Cancer
713 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Bone Metastases
8 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3
Boniva Reviews: What are patients saying about Boniva?
5Patient Review
11/2/2016 I've been on Boniva for four weeks now, and I'm happy to report that I haven't experienced any negative side effects.
2.3Patient Review
4/12/2019 I haven't been able to tell if it's effective yet or not. I just took my third dose, and if it's anything like the first two doses, I won't be taking it again.
2Patient Review
7/31/2021 I started taking Benlista a few days ago and have had some unpleasant side effects every day since then. Really terrible headaches, nausea, dizziness, and it's hard to swallow the pill. I would never recommend this medication to anyone.
1.7Patient Review
5/31/2018 The flu-like symptoms I experienced while taking this medication for two months were not worth the treatment.
1.7Patient Review
6/12/2021 I took this medicine two days ago and have been bedridden since. I'm experiencing pain all over my body at this point. There's no way I'm taking this again – the side effects are far worse than any potential benefits.
1.7Patient Review
7/2/2022 The generic version of Bonita gave me some pretty bad side effects that I'm still feeling even days later. Tylenol has only been managing the pain, and it's been really rough. My doctor agreed that this isn't a medication worth taking again.
1.7Patient Review
12/4/2018 After three months of taking this medication, I can say with certainty that I will not be continuing it for a fourth month. It has caused me immense pain in my fingers and legs, as well as severe hip joint pain.
1Patient Review
12/10/2015 I was given this drug by my doctor and have been taking it for 12 years . I was only supposed to take it for two years, but my GP never informed me. I was suffering from a lot of bone pain--the pain in my feet was affecting my driving, hand pain, back pain. I stopped taking Boniva two months ago and all my pains have gone away. I feel so much better.... Pain free
1Patient Review
4/22/2016 I took one Boniva pill on April 20th, and the next day I experienced incredibly painful symptoms in my arms, legs, and fingers. My vision was also blurred to the point where driving was not an option. Needless to say, I will not be taking this medication again.
1Patient Review
8/9/2018 I had some side effects the first month, but nothing major. The second month was a different story--I experienced horrible pain, dizziness, and vomiting. There's no way I'm taking it for a third month!
1Patient Review
3/8/2017 I would not recommend this medicine to anyone. The side effects are incredibly dangerous and potentially deadly--even before you have osteoporosis!
1Patient Review
11/3/2016 I experienced horrible side effects that made me feel like I was hit by a truck. The pain was excruciating and widespread. I also had to go to the hospital because of disfiguring swelling in my face and neck. I would never recommend this treatment to anyone.
1Patient Review
6/19/2018 I took one pill and the side effects were so bad that I decided it wasn't worth it, even if the treatment actually worked! My whole body was aching, especially my legs, arms, and fingers.
1Patient Review
6/4/2022 I took the recommended dosage and within two hours, I was in immense pain with heartburn. I also had diarrhea, nausea, a headache, and felt cold. For three days after taking this medication, I was housebound because of how weak and fatigued it made me feel!
1Patient Review
5/1/2022 I followed the directions to a tee and started experiencing awful nausea and sharp abdominal pains. This continued on for weeks, including vomiting and gastritis. Save yourself the trouble and avoid this medication entirely.
1Patient Review
7/12/2018 I've just started taking Ibandronate, which is the generic form of Boniva. So far there have been no side effects that I can tell. My pharmacist did suggest that I continue taking a supplement called OsteoBase in addition to the Ibandronate, so I'm doing that.
1Patient Review
3/13/2022 I had extremely unpleasant gastrointestinal symptoms after taking just one pill. I'll be seeking an alternative from my doctor tomorrow.
Patient Q&A Section about boniva
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was Boniva taken off the market?
"Some people are worried about the possible risks of taking bisphosphonates (such as Boniva) for a long time. Some potential risks include atypical femur fractures, osteonecrosis of the jaw, and esophageal cancer."
Answered by AI
What is better Boniva or Fosamax?
"Although both Fosamax and Boniva have been shown to reduce the risk of fractures, Fosamax is generally recommended over Boniva because it is not clear whether Boniva is effective in reducing the risk of hip or nonvertebral fractures."
Answered by AI
How effective is Boniva for osteoporosis?
"After 2 years of treatment, the average spine BMD results were 3.1% to 4.12% better for women given Boniva than for those given a placebo, meaning Boniva is effective in preventing osteoporosis for postmenopausal women."
Answered by AI
What are the side effects from taking Boniva?
"The pill's most common side effects are diarrhea, pain in the extremities, and upset stomach. Its less common side effects may be pain or trouble swallowing, heartburn, and stomach ulcers."
Answered by AI