Droperidol

Delirium, Anaesthesia, Agitation + 4 more

Treatment

5 FDA approvals

20 Active Studies for Droperidol

Treatment for

Delirium

What is Droperidol

DroperidolThe Generic name of this drug

Treatment SummaryDroperidol is a drug similar to haloperidol that is used to help people stay calm and cooperative during surgery when combined with an opioid pain reliever. It is also used as a premedication, to prevent nausea, and to manage agitation caused by acute psychoses.

Droperidolis the brand name

image of different drug pills on a surface

Droperidol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Droperidol

1988

Approved as Treatment by the FDA

Droperidol, otherwise called Droperidol, is approved by the FDA for 5 uses like Nausea and vomiting and diagnostic procedures .

Nausea and vomiting

diagnostic procedures

Anaesthesia

Used to treat Anaesthesia in combination with Fentanyl

Nausea

Induction of Anaesthesia

Used to treat Induction of Anaesthesia in combination with Fentanyl

Effectiveness

How Droperidol Affects PatientsDroperidol makes people feel relaxed and sleepy, while still being able to respond to their surroundings. It can prevent nausea and vomiting during and after surgery, and can also make other drugs used to relax the nervous system more effective. Droperidol can cause low blood pressure and make the vessels wider, which may lower abnormally high blood pressure in the lungs. It may also reduce the chance of a heart rhythm problem caused by epinephrine, but won’t prevent other types of heart rhythm problems.

How Droperidol works in the bodyDroperidol works by depressing levels of activity in the brain, midbrain, and brainstem. It also blocks certain receptors in the brain which are responsible for emotional responses. Its main action is blocking the dopamine receptor, with some additional effects on the alpha-1 adrenergic receptor.

When to interrupt dosage

The advised portion of Droperidol relies upon the recognized disorder, including Surgical Procedures, Delirium and Induction of Anaesthesia. The measure of dosage is subject to the method of delivery (e.g. Liquid - Intramuscular; Intravenous or Injection - Intramuscular; Intravenous) as specified in the table beneath.

Condition

Dosage

Administration

Delirium

, 2.5 mg/mL

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Injection, Liquid, Liquid - Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous

Anaesthesia

, 2.5 mg/mL

Surgical Procedures

, 2.5 mg/mL

Nausea

, 2.5 mg/mL

Induction of Anaesthesia

, 2.5 mg/mL

Agitation

, 2.5 mg/mL

diagnostic procedures

, 2.5 mg/mL

Warnings

Droperidol Contraindications

Condition

Risk Level

Notes

Long QT Syndrome

Do Not Combine

There are 20 known major drug interactions with Droperidol.

Common Droperidol Drug Interactions

Drug Name

Risk Level

Description

Alfuzosin

Major

Droperidol may increase the hypotensive activities of Alfuzosin.

Amiodarone

Major

The risk or severity of QTc prolongation can be increased when Droperidol is combined with Amiodarone.

Amisulpride

Major

The risk or severity of QTc prolongation can be increased when Droperidol is combined with Amisulpride.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Droperidol is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Droperidol is combined with Arsenic trioxide.

Droperidol Toxicity & Overdose RiskThe toxic dose of droperidol in mice is 20-43 mg/kg when given via IV and 195 mg/kg when given via IM. Similarly, the toxic dose in rats is 30 mg/kg IV and 104-110 mg/kg IM, in dogs it is 25 mg/kg IV and in rabbits it is 11-13 mg/kg IV and 97 mg/kg IM. Symptoms of droperidol overdose will be an extension of its normal effects.

image of a doctor in a lab doing drug, clinical research

Droperidol Novel Uses: Which Conditions Have a Clinical Trial Featuring Droperidol?

At present, 54 active trials are exploring the potential of Droperidol to provide Anaesthesia, to facilitate Diagnostic Procedures and to assist in the performance of Surgical Procedures.

Condition

Clinical Trials

Trial Phases

Nausea

0 Actively Recruiting

Agitation

3 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Anaesthesia

0 Actively Recruiting

Induction of Anaesthesia

0 Actively Recruiting

Delirium

26 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 4, Early Phase 1

diagnostic procedures

0 Actively Recruiting

Surgical Procedures

0 Actively Recruiting

Droperidol Reviews: What are patients saying about Droperidol?

5Patient Review

5/30/2013

Droperidol for Nausea and Vomiting After Surgery

My daughter was given this in recovery room after vomiting after her surgery. Worked like a charm....no more nausea/vomiting. I understand now that she didn't sleep afterwards as the medicine kept her awake.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about droperidol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why was droperidol taken off the market?

"The UK Medicines Control Agency raised a warning in the same year about a potential effect of cardiac QT interval prolongation associated with chronic high-dose usage in psychiatric patients, and the drug was quickly removed from the UK market."

Answered by AI

What is the drug droperidol used for?

"This medicine is only to be given by a doctor or under their direct supervision to prevent the nausea and vomiting that may occur after surgery or diagnostic procedures."

Answered by AI

What are side effects of droperidol?

", feeling of warmth, seizures (convulsions), or coma (unconsciousness)

If you experience any of the following symptoms, you may be experiencing a heart attack: fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness. If you experience any of the following symptoms, you may be experiencing heart failure: slow heart rate, weak pulse, fainting, slow breathing (breathing may stop), confusion, hallucinations, feeling of warmth, seizures (convulsions), or coma (unconsciousness)."

Answered by AI

What class of drug is droperidol?

"Droperidol is a drug in the same class as haloperidol (a typical antipsychotic agent) that acts as a dopamine D2 receptor antagonist, producing antiemetic and sedative-hypnotic effects."

Answered by AI

Clinical Trials for Droperidol

Image of Stony Brook University Hospital in Stony Brook, United States.

Transauricular Vagus Nerve Stimulation for Delirium

18+

All Sexes

Stony Brook, NY

The goal of this clinical trial is to test whether a non-invasive device called transauricular vagus nerve stimulation (taVNS) is safe, practical, and potentially helpful for patients in the hospital who develop delirium. Delirium is a state of confusion that often happens to people in the hospital who are sick or hurt. It can cause agitation, trouble paying attention and difficulty understanding what is happening. Delirium may slow overall recovery. This study will focus on feasibility and safety. Researchers want to learn whether taVNS can be given safely to critically-ill patients, whether patients and staff can tolerate the treatments, and whether the device produces measurable changes in brain activity and brain oxygen levels. The main questions this study aims to answer are: * Is it possible to deliver taVNS safely and consistently to patients in the ICU who have delirium? * Do patients tolerate the device without significant side effects or complications? * Does taVNS cause short-term changes in brain signals and oxygen levels that may suggest effects on brain function? This is an early feasibility study and there is no randomization or placebo group. All patients enrolled will receive taVNS in addition to their usual hospital care for delirium. What participants will do: * Be identified by their hospital care team and have a confirmed diagnosis of delirium. * Provide consent (or have a legally authorized representative provide consent if the patient cannot.) * Undergo brief assessments of thinking and attention (for example, the CAM-ICU test.) * Receive taVNS treatment using a small clip electrode placed on the ear. * The device sends gentle electrical pulses to the nerve in the ear. * Each session lasts about 30 minutes, given twice per day (morning and evening, with at least 6 hours between sessions). * Treatment can continue for up to 7 days while the patient is in the ICU. * Be monitored during and after each session. The study team will check vital signs, examine the ear for irritation, and ask about any discomfort. * On the first day, researchers will also record brain signals (EEG) and brain oxygen levels before and during stimulation using FDA-approved hospital monitoring devices. Possible risks and discomforts: * Mild side effects are possible, such as tingling, a tickling or pricking feeling in the ear, or temporary skin redness where the clip is placed. * Serious side effects are not expected, but all patients will be closely monitored during and after each session to ensure safety. Possible benefits: • Patients may or may not experience personal benefit. The main benefit is helping researchers learn whether this treatment approach is safe and practical. In the future, taVNS could potentially become a new tool to help treat or prevent delirium in hospitalized patients. Study size and duration: * The study will enroll a limited number of ICU patients with delirium at Stony Brook University Hospital. * Patients may take part for up to 7 days while hospitalized. Who can join: * Right-handed, adult patients in the ICU who are diagnosed with delirium. * People with certain medical conditions (such as brain bleeds, new strokes, pacemakers or other contraindications) may not be able to participate, for safety reasons.

Recruiting

Has No Placebo

Stony Brook University HospitalIsadora Botwinick, MD

Have you considered Droperidol clinical trials? We made a collection of clinical trials featuring Droperidol, we think they might fit your search criteria.

Image of Sarasota Memorial Health Care System in Sarasota, United States.

Robotic Pets for Dementia

65+

All Sexes

Sarasota, FL

Robotic pets can provide a source of affection and companionship for patients. This is especially important as individuals with dementia may receive infrequent visitation from family members if their families struggle with how to cope and communicate with their loved one. Several options such as the "Joy for All™" and "Paro" robotic pets offer a source of companionship that is both interactive and comforting. Sarasota Memorial Health Care System (SMHCS) researchers are seeking to make companion pets available to patients with dementia to provide them with a supplemental enrichment experience that enhances their overall care and lowers their risk for superimposed delirium. The intervention will consist of providing a robotic pet to the patient within 48 hours of admission, which the patient will keep with them throughout their hospital stay and upon discharge. SMHCS researchers will evaluate the effects of the robotic pet interaction on patient delirium scores, as measured by the Nursing Delirium Screening Scale (Nu-DESC), length of stay, and the use of intravenous psychotropic medications, code greys, falls occurrence, restraint use, and IV dislodgement in patients with mild-to-moderate dementia. The Nu-DESC scale is a short assessment tool, estimated to take approximately 3-5 minutes to complete and is already part of standard care at SMHCS. This tool is used by nursing staff with minimal additional training and shows consistent sensitivity (85.7%) and specificity (86.8%) in detecting delirium. The NuDESC score may be positive in a patient with dementia, since some characteristics of dementia can be similar to delirium. However, patients with dementia are at higher risk for developing delirium, so the NuDESC is a helpful tool for the nurse. A score of 2 or higher is considered screening positive for delirium. For this study, the NuDESC tool will be used as a guideline to assist in the screening of delirium. The patients will have to score a 4 or less to be included in the study. Patients that are scoring \>4 will be excluded. Theoretic Framework of Acceptability (TFA) is a questionnaire which will be used to assess health care provider acceptability of the companion animal. This tool is currently not in use at SMHCS, but it will be used as part of this study to assess whether health care providers accept (or reject) the robotic pets as companion animals.

Waitlist Available

Has No Placebo

Sarasota Memorial Health Care SystemJoanna D'Elia, MSN, RN, GERO-BC

Have you considered Droperidol clinical trials? We made a collection of clinical trials featuring Droperidol, we think they might fit your search criteria.