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What is Droperidol
DroperidolThe Generic name of this drug
Treatment SummaryDroperidol is a drug similar to haloperidol that is used to help people stay calm and cooperative during surgery when combined with an opioid pain reliever. It is also used as a premedication, to prevent nausea, and to manage agitation caused by acute psychoses.
Droperidolis the brand name
Droperidol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Droperidol
Droperidol
1988
11
Approved as Treatment by the FDA
Droperidol, otherwise called Droperidol, is approved by the FDA for 4 uses like diagnostic procedures and Nausea .diagnostic procedures
Nausea
Anaesthesia
Used to treat Anaesthesia in combination with Fentanyl
Induction of Anaesthesia
Used to treat Induction of Anaesthesia in combination with Fentanyl
Effectiveness
How Droperidol Affects PatientsDroperidol makes people feel relaxed and sleepy, while still being able to respond to their surroundings. It can prevent nausea and vomiting during and after surgery, and can also make other drugs used to relax the nervous system more effective. Droperidol can cause low blood pressure and make the vessels wider, which may lower abnormally high blood pressure in the lungs. It may also reduce the chance of a heart rhythm problem caused by epinephrine, but won’t prevent other types of heart rhythm problems.
How Droperidol works in the bodyDroperidol works by depressing levels of activity in the brain, midbrain, and brainstem. It also blocks certain receptors in the brain which are responsible for emotional responses. Its main action is blocking the dopamine receptor, with some additional effects on the alpha-1 adrenergic receptor.
When to interrupt dosage
The advised portion of Droperidol relies upon the recognized disorder, including Surgical Procedures, Delirium and Induction of Anaesthesia. The measure of dosage is subject to the method of delivery (e.g. Liquid - Intramuscular; Intravenous or Injection - Intramuscular; Intravenous) as specified in the table beneath.Condition
Dosage
Administration
Nausea
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
Induction of Anaesthesia
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
Anaesthesia
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
Delirium
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
Agitation
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
diagnostic procedures
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
Surgical Procedures
, 2.5 mg/mL
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous
Warnings
Droperidol ContraindicationsCondition
Risk Level
Notes
Prolonged QT Interval
Do Not Combine
Common Droperidol Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Droperidol may increase the hypotensive activities of Alfuzosin.
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Droperidol is combined with Amiodarone.
Amisulpride
Major
The risk or severity of QTc prolongation can be increased when Droperidol is combined with Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Droperidol is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Droperidol is combined with Arsenic trioxide.
Droperidol Toxicity & Overdose RiskThe toxic dose of droperidol in mice is 20-43 mg/kg when given via IV and 195 mg/kg when given via IM. Similarly, the toxic dose in rats is 30 mg/kg IV and 104-110 mg/kg IM, in dogs it is 25 mg/kg IV and in rabbits it is 11-13 mg/kg IV and 97 mg/kg IM. Symptoms of droperidol overdose will be an extension of its normal effects.
Droperidol Novel Uses: Which Conditions Have a Clinical Trial Featuring Droperidol?
At present, 54 active trials are exploring the potential of Droperidol to provide Anaesthesia, to facilitate Diagnostic Procedures and to assist in the performance of Surgical Procedures.Condition
Clinical Trials
Trial Phases
Delirium
49 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 4, Phase 1, Early Phase 1
Surgical Procedures
0 Actively Recruiting
Nausea
0 Actively Recruiting
Anaesthesia
0 Actively Recruiting
Induction of Anaesthesia
0 Actively Recruiting
diagnostic procedures
0 Actively Recruiting
Agitation
5 Actively Recruiting
Phase 3, Phase 2
Droperidol Reviews: What are patients saying about Droperidol?
5Patient Review
5/30/2013 My daughter was given this in recovery room after vomiting after her surgery. Worked like a charm....no more nausea/vomiting. I understand now that she didn't sleep afterwards as the medicine kept her awake.
Patient Q&A Section about droperidol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was droperidol taken off the market?
"The UK Medicines Control Agency raised a warning in the same year about a potential effect of cardiac QT interval prolongation associated with chronic high-dose usage in psychiatric patients, and the drug was quickly removed from the UK market."
Answered by AI
What is the drug droperidol used for?
"This medicine is only to be given by a doctor or under their direct supervision to prevent the nausea and vomiting that may occur after surgery or diagnostic procedures."
Answered by AI
What are side effects of droperidol?
", feeling of warmth, seizures (convulsions), or coma (unconsciousness)
If you experience any of the following symptoms, you may be experiencing a heart attack: fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness. If you experience any of the following symptoms, you may be experiencing heart failure: slow heart rate, weak pulse, fainting, slow breathing (breathing may stop), confusion, hallucinations, feeling of warmth, seizures (convulsions), or coma (unconsciousness)."
Answered by AI
What class of drug is droperidol?
"Droperidol is a drug in the same class as haloperidol (a typical antipsychotic agent) that acts as a dopamine D2 receptor antagonist, producing antiemetic and sedative-hypnotic effects."
Answered by AI