Edarbyclor

Atrial Fibrillation, Albuminuria, Type 2 Diabetes + 2 more
Treatment
2 FDA approvals
20 Active Studies for Edarbyclor

What is Edarbyclor

Azilsartan medoxomilThe Generic name of this drug
Treatment SummaryAzilsartan medoxomil, sold under the brand name Edarbi, is a drug used to treat high blood pressure. It works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. It is usually prescribed as mono-therapy or in combination with other antihypertensive drugs. It may help reduce the risk of cardiovascular events like stroke and heart attack. Azilsartan medoxomil may also have potential off-label uses in patients with a history of heart failure or heart attack.
Edarbiis the brand name
image of different drug pills on a surface
Edarbyclor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Edarbi
Azilsartan medoxomil
2011
10

Approved as Treatment by the FDA

Azilsartan medoxomil, otherwise known as Edarbi, is approved by the FDA for 2 uses including Hypertensive disease and inadequate response to monotherapy .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Chlorthalidone

Effectiveness

How Edarbyclor Affects PatientsAzilsartan medoxomil helps to lower blood pressure by blocking the angiotensin II receptor, which helps to reduce the amount of pressure in the blood vessels. It is not affected by a person's sex, race, or any form of kidney or liver impairment. In addition, it does not affect potassium, sodium, or bradykinin levels. Studies have shown that it can significantly reduce blood pressure in just one dose. There is no evidence that it works differently in people of African descent.
How Edarbyclor works in the bodyAzilsartan medoxomil helps regulate blood pressure by blocking the effects of angiotensin II. Angiotensin II is a hormone that causes blood vessels to narrow, making blood pressure rise. Azilsartan binds to the receptor responsible for angiotensin II, blocking its effects and lowering blood pressure. It is more effective than other medications in this class because it binds more tightly to the receptor and takes longer to dissociate.

When to interrupt dosage

The recommended dosage of Edarbyclor hinges upon the diagnosed disorder, such as Hypertensive disease, Atrial Fibrillation and Albuminuria. The amount of dosage is contingent upon the delivery approach featured in the table below.
Condition
Dosage
Administration
Atrial Fibrillation
40.0 mg, , 80.0 mg, 20.0 mg
Oral, Tablet, , Tablet - Oral
Hypertensive disease
40.0 mg, , 80.0 mg, 20.0 mg
Oral, Tablet, , Tablet - Oral
Albuminuria
40.0 mg, , 80.0 mg, 20.0 mg
Oral, Tablet, , Tablet - Oral
Type 2 Diabetes
40.0 mg, , 80.0 mg, 20.0 mg
Oral, Tablet, , Tablet - Oral
inadequate response to monotherapy
40.0 mg, , 80.0 mg, 20.0 mg
Oral, Tablet, , Tablet - Oral

Warnings

Edarbyclor Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Anuria
Do Not Combine
There are 20 known major drug interactions with Edarbyclor.
Common Edarbyclor Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Azilsartan medoxomil may increase the hypotensive activities of Amifostine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Azilsartan medoxomil.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Azilsartan medoxomil.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Azilsartan medoxomil.
Sacubitril
Major
The risk or severity of angioedema can be increased when Azilsartan medoxomil is combined with Sacubitril.
Edarbyclor Toxicity & Overdose RiskThere is no known maximum toxic dose of azilsartan yet. In clinical trials, healthy individuals tolerated a single dose of up to 320 mg without any significant side effects. If an overdose occurs, supportive measures should be taken as azilsartan cannot be removed through dialysis. Azilsartan is also a teratogenic agent, meaning it can cause birth defects if taken during the second or third trimesters of pregnancy.
image of a doctor in a lab doing drug, clinical research

Edarbyclor Novel Uses: Which Conditions Have a Clinical Trial Featuring Edarbyclor?

At present, 265 active clinical trials are assessing the utility of Edarbyclor for Atrial Fibrillation, inadequate response to monotherapy, and Albuminuria control.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
96 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Albuminuria
1 Actively Recruiting
Phase 2
Atrial Fibrillation
95 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
inadequate response to monotherapy
0 Actively Recruiting
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Edarbyclor Reviews: What are patients saying about Edarbyclor?

5Patient Review
1/8/2016
Edarbyclor for High Blood Pressure
I've always had low blood pressure, but I got extremely sick and my blood pressure shot up to 244/166. I went to the ER and was given a shot and a pill, then sent home. My family doctor saw me the next day and diagnosed me with stage three kidney failure. I was taking five different medications eleven times a day at that point, and it was consuming my life. But then I was put on edarbyclor and bystolic, and now my blood pressure is down to 106/64. I do have bad muscle weakness and heart problems, but overall this medication has been a lifes
5Patient Review
3/20/2019
Edarbyclor for High Blood Pressure
This treatment has been a godsend for me. I've had hypertension for years and have tried every medication out there with little success. But as soon as I started taking Edarbi, my blood pressure dropped significantly. I'm now down to an average of 130/70, and it only costs me $40 a month!
5Patient Review
1/25/2022
Edarbyclor for High Blood Pressure
After years of treatments that didn't work, this was a complete change for the better. It's pricey, but to me it was worth every penny. Additionally, I experienced no negative side effects. From what I can tell based on other reviews, it doesn't work for everyone. But it worked extremely well for me and I'm very grateful.
5Patient Review
5/13/2021
Edarbyclor for High Blood Pressure
This medication was the only one that actually helped lower my blood pressure. In just two weeks, it went from an average of 140/100 to 110/70. I also didn't experience any negative side effects, which was great.
5Patient Review
1/26/2021
Edarbyclor for High Blood Pressure
I had hypertension for 30 years that didn't respond to any treatment I tried—until this one. Within two weeks of taking it, my blood pressure dropped significantly. The only side effect was occasional dizziness when it would drop too low, but that's a small price to pay compared to the alternative of high blood pressure.
5Patient Review
2/23/2017
Edarbyclor for High Blood Pressure
In an emergency situation, my doctor gave me a sample of this medication. Within 30 minutes, my blood pressure had decreased from 190/100 to 140/80. This was nothing short of miraculous for me given my history of high blood pressure, strokes, diabetes, multiple sclerosis, and allergies.
5Patient Review
7/10/2016
Edarbyclor for High Blood Pressure
Since switching to Edarbyclor 40/25 mg from my previous medication (Valsartan & HTZ), my blood pressure has decreased slightly. I've also experienced some fatigue, but overall I'm pleased with the results so far.
5Patient Review
11/16/2017
Edarbyclor for High Blood Pressure
Edarbyclor and Bystolic have finally helped me get my high blood pressure under control.
5Patient Review
3/23/2019
Edarbyclor for High Blood Pressure
I had tried a few different treatments before this one, and none of them worked as well as this one has. In just two weeks, my blood pressure has dropped significantly.
5Patient Review
11/15/2017
Edarbyclor for High Blood Pressure
No negative effects and great results.
4Patient Review
7/20/2019
Edarbyclor for High Blood Pressure
I've only been taking this medication for a week, but I'm already seeing results that I like. The only downside is that my arms feel tired, but the doctor said I should expect that.
4Patient Review
3/14/2016
Edarbyclor for High Blood Pressure
I had to stop taking this after just one pill because it made me feel faint and unsteady. I was also incoherent and my fingers were tingling.
4Patient Review
3/30/2015
Edarbyclor for High Blood Pressure
1.7Patient Review
12/20/2018
Edarbyclor for High Blood Pressure
I tried this for around eight months, and it just gave me a lot of terrible side effects. I would never recommend it to anyone.
1Patient Review
12/21/2017
Edarbyclor for High Blood Pressure
This medication has caused me a great deal of pain and discomfort. I stopped taking it three days ago, and I'm still feeling the effects. My doctor says it's not the medication, but I find that hard to believe.
1Patient Review
1/10/2016
Edarbyclor for High Blood Pressure
I took up to 100mg of Metoprolol per day, and it did nothing for me. I tried Lisinopril and Amlodapine next, but experienced only negative side effects. Finally, I started taking Edarbyclor, and my blood pressure lowered significantly within days. Give it a chance!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about edarbyclor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Edarbyclor hard on the kidneys?

"This medication can have harmful effects on the blood vessels of the brain, heart, and kidneys, which can lead to stroke, heart failure, or kidney failure."

Answered by AI

What side effects does Edarbyclor have?

"If you experience any of the following symptoms, you may be experiencing an electrolyte imbalance:

-Swelling

-Weight gain

-Feeling short of breath

-Dry mouth

-Extreme thirst

-Drowsiness

-Restless feeling

-Confusion

-Increased or decreased urination

-Constipation

-Muscle pain or weakness

-Fast heart rate

-Seizures or convulsions"

Answered by AI

What is Edarbyclor used to treat?

"Both EDARBI and EDARBYCLOR are used to treat hypertension, but your doctor may also prescribe additional medication to be taken alongside either of these drugs."

Answered by AI

What is the generic for Edarbyclor?

"Although there is no generic version of Edarbyclor currently available, there are ways to lower the cost of this medication. GoodRx coupons, copay cards, and patient assistance programs can help reduce the expense."

Answered by AI

Clinical Trials for Edarbyclor

Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA
The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.
Phase 4
Waitlist Available
Inova Alexandria Hospital
Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Edarbyclor clinical trials? We made a collection of clinical trials featuring Edarbyclor, we think they might fit your search criteria.Go to Trials
Have you considered Edarbyclor clinical trials? We made a collection of clinical trials featuring Edarbyclor, we think they might fit your search criteria.Go to Trials
Image of Mission Cardiovascular Research Institute in Fremont, United States.

REGN7508 + REGN9933 for Atrial Fibrillation

18+
All Sexes
Fremont, CA
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Phase 2
Recruiting
Mission Cardiovascular Research Institute (+4 Sites)Clinical Trial ManagementRegeneron Pharmaceuticals
Have you considered Edarbyclor clinical trials? We made a collection of clinical trials featuring Edarbyclor, we think they might fit your search criteria.Go to Trials
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