Hypertension Clinical Trials
Hypertension studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect hypertension clinical trial.
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Hypertension
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Clinical Trials
Hypertension Clinical Trials
Phase-Based Estimates
1
Effectiveness
1
Safety
Diabetes Prevention Program Plus (DPP+)
for Hypertension
Galveston, TX
18 - 65
Female
Recruiting
Galveston, TX
18 - 65
Female
Nearly half of women have obesity and/or hypertension (HTN). Specific to women, pregnancy creates a vulnerable window for excess gestational weight gain (GWG), exacerbating intergenerational risks for obesity, HTN, type 2 diabetes (T2D), and cardiovascular disease (CVD) across the lifespan. Healthy lifestyles are the first-line recommendations for prevention and treatment of overweight/obesity, HTN, T2D, and CVD. The Diabetes Prevention Program (DPP) is a well-established, Centers for Disease Control and Prevention (CDC)-led public health program focusing on healthy lifestyle changes and is effective at reducing 5-7% of body weight, lowering risks for T2D. Interestingly, research investigating the DPP as a lifestyle intervention for other chronic conditions (i.e., overweight/obesity and HTN) is lacking, demonstrating a missed opportunity. The aim of this study is to determine the initial effects of the first 6-months and after receiving the full 12-months of the virtual DPP compared to the DPP expanded with a CDC-approved HTN prevention component (DPP+) on physical activity, diet, weight, and CVD risk factors in 30 prediabetic women (18-45 years old) with a history of excess GWG, overweight/obesity, and HTN. Participants will be recruited through University of Texas Medical Branch (UTMB) community-based clinics using Epic. The Participants will be randomized into 2 groups (DPP and DPP+) and guided through the 12-month virtual DPP or DPP+ program using UTMB DPP personnel.
Phase-Based Estimates
1
Effectiveness
1
Safety
Diuretic Algorithm
for Chronic Kidney Diseases
Edmonton, Canada
18+
All Sexes
Waitlist Available
Edmonton, Canada
18+
All Sexes
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
Phase-Based Estimates
1
Effectiveness
2
Safety
Angiotensin II Receptor Blockers (ARBs, Losartan) And Calcium Channel Blockers (CCB, Amlodipine)
for Hypertension
Dallas, TX
18+
All Sexes
Phase 2
Waitlist Available
High Risk
Dallas, TX
18+
All Sexes
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau protein deposition) in older adults at high risk for memory decline or dementia.
Phase-Based Estimates
1
Effectiveness
1
Safety
Heart Rate Variability
for Hypertension
Atlanta, GA
18+
All Sexes
Recruiting
Stage I
Atlanta, GA
18+
All Sexes
The Life University Center for Chiropractic Research is conducting a research study to better understand the physiological differences, in terms of Autonomic nervous system function, between individuals with Hypertension and control individuals with out hypertension. Data will be gathered using Heart Rate Variability (HRV), and Galvanic Skin Response (GSR). A series of tests will be conducted to elicit Autonomic Nervous system responses. These tests include Cold Face Test (mammalian dive reflex), Cold Pressor test, Sit to stand, and the Valsalva maneuver.
Phase-Based Estimates
1
Effectiveness
1
Safety
No Cooling (control)
for Hypertension
Ottawa, Canada
18+
All Sexes
Waitlist Available
Ottawa, Canada
18+
All Sexes
With the increasing incidence and severity of extreme heat events accompanying climate change, there is an urgent need for sustainable cooling strategies to protect heat-vulnerable older adults, who are at increased risk of adverse health events during heat stress. Health agencies including the World Health Organization, the United States Centers for Disease Control and Prevention, and Health Canada currently recommend visiting a cooling centre or other air-conditioned location for 1-3 hours per day during extreme heat events to mitigate hyperthermia and strain on the cardiovascular system and therefore the risk adverse health events. However, our recent trial shows that while brief air-conditioning exposure is effective for reducing body temperature and cardiovascular burden in healthy older adults, the physiological impacts of cooling abate quickly following return to the heat. The purpose of this project is therefore to assess whether shorter but more frequent air-conditioning exposure provides more effective cooling than current recommendations (a single 1-3-hour cooling bout) in older adults with or without common chronic health conditions associated with increased vulnerability to extreme heat. This will be accomplished by evaluating physiological strain in older adults with and without diabetes and/or hypertension exposed for 8 hours to conditions reflective of extreme heat events in temperate, continental climates (35°C, 60% relative humidity). Participants will complete 3 separate simulated heat event exposures: i) a control trial (no cooling throughout the 8-hour heat event); ii) a recommended cooling trial (3 hours of heat exposure followed by 2 hours cooling); and iii) a hybrid cooling trial (2 hours of heat exposure followed by 1 hour cooling, another 2 hours heat exposure followed by 1 hour cooling, and a final 2-hour heat exposure).
Phase-Based Estimates
2
Effectiveness
3
Safety
PRM-125
for Hypertension
Coral Gables, FL
18+
All Sexes
Phase 3
Recruiting
Coral Gables, FL
18+
All Sexes
Evaluation of Once-Daily PRM125 On Ambulatory Blood Pressure in Adults with Hypertension
Phase-Based Estimates
1
Effectiveness
2
Safety
Amlodipine
for Hypertension
Memphis, TN
18+
All Sexes
Phase 2
Recruiting
Memphis, TN
18+
All Sexes
The purpose of this study is to evaluate the effect of zilebesiran on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of zilebesiran as add-on therapy.
Phase-Based Estimates
1
Effectiveness
1
Safety
Sleep Hygiene/extension Intervention
for Hypertension
New York, NY
18+
All Sexes
Recruiting
New York, NY
18+
All Sexes
This study is evaluating whether sleep duration has an impact on blood pressure during sleep.
Phase-Based Estimates
1
Effectiveness
1
Safety
Youth-Led Hypertension Education Digital Badge
for Adolescent Behaviors
New Brunswick, NJ
Any Age
All Sexes
Recruiting
New Brunswick, NJ
Any Age
All Sexes
This study is evaluating whether a digital badge that teaches adults how to teach youth about HTN control can improve HTN control in adults with uncontrolled HTN.
Phase-Based Estimates
1
Effectiveness
1
Safety
Telehealth Consult
for Hypertension
New York, NY
18+
All Sexes
Recruiting
New York, NY
18+
All Sexes
This study is evaluating whether a telehealth intervention can improve blood pressure control and primary care engagement in patients with uncontrolled hypertension.
Phase-Based Estimates
1
Effectiveness
2
Safety
AD113
for Hypertension
Towson, MD
18+
All Sexes
Phase 2
Recruiting
Towson, MD
18+
All Sexes
This study is evaluating whether atomoxetine is more effective than AD113 in treating OSA.
Phase-Based Estimates
2
Effectiveness
3
Safety
Stepped-care Protocol Adapted From The SPRINT Intensive-treatment Algorithm
for Cognitive Decline
New Orleans, LA
18+
All Sexes
Phase 3
Recruiting
New Orleans, LA
18+
All Sexes
This study is evaluating whether a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income
Phase-Based Estimates
3
Effectiveness
3
Safety
Eplerenone
for Obesity
Boston, MA
18+
All Sexes
Phase 4
Recruiting
Stage I
Boston, MA
18+
All Sexes
This study is evaluating whether a drug may help improve heart function in individuals with high blood pressure.
Phase-Based Estimates
1
Effectiveness
1
Safety
Tai Chi
for Hypertension
Storrs, CT
18+
All Sexes
Recruiting
Storrs, CT
18+
All Sexes
This study is evaluating whether a single session of Tai Chi followed by a 12-week online Tai Chi program with easy movements can improve blood pressure and cognitive function, focusing on executive function.
Phase-Based Estimates
1
Effectiveness
1
Safety
WOW Intervention
for Prehypertension
Baltimore, MD
18+
All Sexes
Waitlist Available
Baltimore, MD
18+
All Sexes
This study is evaluating whether a new program can help improve blood pressure for individuals who visit a pharmacy.
Phase-Based Estimates
1
Effectiveness
1
Safety
Nudge
for Cardiovascular Diseases
Aurora, CO
18+
All Sexes
Recruiting
Aurora, CO
18+
All Sexes
This study is evaluating whether text messages may help patients take their medications.
Phase-Based Estimates
1
Effectiveness
1
Safety
Adherence-enhanced Clinical Decision Support
for Lipidemia
Bloomington, MN
18+
All Sexes
Waitlist Available
Bloomington, MN
18+
All Sexes
This study is evaluating whether a system of care can improve medication adherence for people with diabetes, hypertension, or lipid disorders.
Phase-Based Estimates
1
Effectiveness
1
Safety
Paced Breathing
for Inflammation
Miami, FL
18+
All Sexes
Recruiting
Miami, FL
18+
All Sexes
This study is evaluating whether a specific type of stress test may help predict cardiovascular risk in individuals with HIV.
Phase-Based Estimates
1
Effectiveness
1
Safety
CVRS Intervention
for Hypertension
Mahomet, IL
18+
All Sexes
Waitlist Available
Mahomet, IL
18+
All Sexes
This study is evaluating whether a remote, pharmacist-led cardiovascular risk service (CVRS) in 12 large, organizationally and culturally diverse hospitals and health-systems, many with high
Phase-Based Estimates
1
Effectiveness
2
Safety
Tamoxifen
for Pulmonary Arterial Hypertension
Nashville, TN
18+
All Sexes
Phase 2
Recruiting
Class I
Nashville, TN
18+
All Sexes
This study is evaluating whether tamoxifen may have positive impacts for individuals with pulmonary arterial hypertension.
Phase-Based Estimates
1
Effectiveness
1
Safety
MobiusHD
for Hypertension
Tampa, FL
18+
All Sexes
Waitlist Available
Tampa, FL
18+
All Sexes
This study is evaluating whether a device can improve the quality of life for people with Parkinson's disease.
Phase-Based Estimates
1
Effectiveness
1
Safety
Resveratrol
for Hypertension
Baltimore, MD
18+
All Sexes
Phase 1 & 2
Recruiting
Baltimore, MD
18+
All Sexes
Background: - Resveratrol is a compound found in the skin of red grapes. It is being tested to see if it can have positive effects on human health. Lab studies show that it may help lower blood sugar, improve heart and blood vessel health, and prevent cancer. Researchers want to test different dose levels of Resveratrol to see what kind of effects it has on older overweight people. It will be tested in healthy volunteers at least 50 years of age. Objectives: - To test the effects of different dose levels of Resveratrol on heart and blood vessel health. Eligibility: - Healthy overweight nonsmoking volunteers at least 50 years of age. Design: This study will involve a screening visit and four study visits. Some of the study visits will involve overnight inpatient stays. Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. They will be given a list of foods that they should avoid eating while on the study. Participants will be separated into three groups. Two groups will take different dose levels of the study drug. The third group will take a placebo. At the first study visit, participants will stay in the clinical center overnight for 2 days of tests. They will provide blood and urine samples and have body scans to measure fat and muscle mass. They will also have exercise tests. A muscle biopsy will also be performed. At this visit, they will receive their dose of the study drug. They will continue to take this dose for as long as they are on the study. The second visit will be 16 weeks after the first one. It will take only 2 hours, and repeat most of the tests from the screening visit. The third visit will be 16 weeks later. It will involve an overnight stay. Most of the tests from the second visit will be repeated. The fourth and final visit will be 16 weeks later. It will involve an overnight stay. Most of the tests from the initial study visit (including the scans and the exercise tests) will be repeated.
Phase-Based Estimates
1
Effectiveness
1
Safety
Dietitian-Assisted DASH Groceries
for Hypertension
Boston, MA
18+
All Sexes
Waitlist Available
Boston, MA
18+
All Sexes
GoFreshRx is a randomized trial, testing the effects of a home-delivered DASH-patterned grocery intervention on blood pressure in Black adults actively treated for hypertension, residing in Boston area urban food deserts.
Phase-Based Estimates
1
Effectiveness
1
Safety
Instructions
for Hypertension
Winston-Salem, NC
18+
Female
Recruiting
Winston-Salem, NC
18+
Female
The purpose of this research study is to find out the usefulness of checking a woman's blood pressure remotely (at home) for 3 weeks after being discharged from the hospital after having a baby (or babies). Some women can develop hypertension, or high BP, after delivery even if they have not had this problem before or during their pregnancy. Untreated or unknown high BP can lead to medical complications, and if severe, can be life threatening. Monitoring, or checking, remote BP after a woman has delivered her baby (or babies) has been suggested to be a better way to monitor BPs without having to stay in the hospital for a longer time after delivery. Other researchers report that women who have checked their BP remotely after delivery found out that this was both possible and acceptable.
Phase-Based Estimates
1
Effectiveness
1
Safety
Yoga
for Hypertension
San Marcos, TX
18 - 65
All Sexes
Waitlist Available
Stage I
San Marcos, TX
18 - 65
All Sexes
The proposed study will assess the effects of yoga postures and slow, deep breathing in altering oxidative stress, vascular function, and blood pressure.
Phase-Based Estimates
1
Effectiveness
1
Safety
Dietitian-Assisted DASH Groceries
for High Blood Pressure (Hypertension)
Boston, MA
18+
All Sexes
Recruiting
Boston, MA
18+
All Sexes
This study is evaluating whether a home-delivered DASH-patterned grocery intervention can lower blood pressure in Black adults, residing in Boston urban food deserts.
Phase-Based Estimates
1
Effectiveness
1
Safety
PAL2
for Hypertension
Detroit, MI
18+
All Sexes
Waitlist Available
Detroit, MI
18+
All Sexes
This study is evaluating whether a surgery which reduces blood flow in a stomach artery leads to significant weightloss.
Phase-Based Estimates
1
Effectiveness
2
Safety
Sacubitril-Valsartan 49 Mg-51 Mg Oral Tablet
for Cardiovascular Diseases
Birmingham, AL
18+
All Sexes
Phase 2 & 3
Recruiting
Birmingham, AL
18+
All Sexes
This study is evaluating whether a medication that targets the renin-angiotensin-aldosterone system (RAAS) can be used to treat nocturnal hypertension in obese individuals.
Phase-Based Estimates
1
Effectiveness
1
Safety
Community Health Navigator Program
for Chronic Kidney Diseases
Edmonton, Canada
18+
All Sexes
Recruiting
Stage III
Edmonton, Canada
18+
All Sexes
This study is evaluating whether a patient navigation program can improve care for patients with long-term health conditions.
Phase-Based Estimates
1
Effectiveness
1
Safety
Opt-In Recruitment
for Hypertension
Philadelphia, PA
18+
All Sexes
Waitlist Available
Philadelphia, PA
18+
All Sexes
This study is evaluating whether different approaches to recruiting patients to participate in a 6-month remote monitoring program for the management of hypertension (HTN) are effective.
Phase-Based Estimates
1
Effectiveness
2
Safety
GnRH Antagonist + MethylTESTOSTERone 5 MG
for Sclerocystic Ovaries
New Haven, CT
18 - 65
Female
Phase 2
Waitlist Available
New Haven, CT
18 - 65
Female
This study is evaluating whether a medication that reduces blood pressure in women with androgen excess polycystic ovary syndrome (AE-PCOS) also reduces the risk of developing hypertension.
Phase-Based Estimates
1
Effectiveness
1
Safety
Hot Yoga
for Hypertension
San Marcos, TX
18+
All Sexes
Recruiting
Stage I
San Marcos, TX
18+
All Sexes
This study is evaluating whether a yoga intervention may help improve vascular health in adults.
Phase-Based Estimates
1
Effectiveness
1
Safety
Intervention
for Hypertension
Boston, MA
18+
All Sexes
Waitlist Available
Boston, MA
18+
All Sexes
In this project the investigators will create computer reminders through user-centered design and will validate the logic using retrospective electronic health record (EHR) data. Then the investigators will test the reminders in primary care clinics to see if they improve treatment of high blood pressure in early chronic kidney disease. Hypothesis: The mean systolic blood pressure of the chronic kidney disease (CKD) population can be decreased by an intervention with three innovative features: 1) methods to synthesize EHR data in order to identify under-diagnosed chronic conditions, 2) iterative improvement in clinical decision support (CDS) content through human factors methods to maximize the "informativeness" of the CDS, and 3) the use of behavioral economic principles to create behavioral "nudges" internal and external to the CDS.
Phase-Based Estimates
1
Effectiveness
1
Safety
Socially-Based Exercise Intervention For Older Adults
for Sarcopenia
Scotts Hill, TN
18+
All Sexes
Recruiting
Scotts Hill, TN
18+
All Sexes
This study is evaluating whether a mobile application may help improve the health of older adults.
Phase-Based Estimates
1
Effectiveness
1
Safety
Heat Therapy Group
for Hypertension
Eugene, OR
18 - 65
All Sexes
Recruiting
Stage I
Eugene, OR
18 - 65
All Sexes
This study is evaluating whether hot water immersion is better than aerobic exercise for reducing blood pressure.
Phase-Based Estimates
3
Effectiveness
3
Safety
Clonidine Pill
for Anxiety Disorders
Iowa City, IA
18+
All Sexes
Phase 4
Waitlist Available
Iowa City, IA
18+
All Sexes
This study is evaluating whether a short-term (4 weeks) pharmacological blockade of sympathetic nerve activity (clonidine) can improve anxiety symptoms, vascular function, inflammation, muscle sympathetic nerve activity, and oxidant stress in individuals with moderate-to-high anxiety.
Phase-Based Estimates
1
Effectiveness
1
Safety
Education
for Dyslipidemias
Seattle, WA
18+
All Sexes
Waitlist Available
Seattle, WA
18+
All Sexes
This study is evaluating whether a set of educational interventions can improve the control of hypertension, dyslipidemia, and diabetes in survivors of childhood cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
The Complete Health Improvement Program
for Dyslipidemias
Athens, OH
18+
All Sexes
Recruiting
Athens, OH
18+
All Sexes
This study is evaluating whether a program which helps individuals with chronic disease can help improve their health.
Phase-Based Estimates
1
Effectiveness
1
Safety
Angiotensin-II, Valsartan
for Pulmonary Arterial Hypertension
Salt Lake City, UT
18+
All Sexes
Phase 1
Recruiting
Class I
Salt Lake City, UT
18+
All Sexes
This study is evaluating whether a drug may help improve blood flow to muscles in older adults.
Phase-Based Estimates
1
Effectiveness
1
Safety
Protocol-based Integrated Care
for Diabetes Complications
New Orleans, LA
18+
All Sexes
Waitlist Available
New Orleans, LA
18+
All Sexes
This study is evaluating whether a set of activities can improve blood sugar levels in people with diabetes.
Phase-Based Estimates
1
Effectiveness
1
Safety
The Paradise® Renal Denervation Ultrasound System
for Hypertension
Boston, MA
18+
All Sexes
Waitlist Available
Boston, MA
18+
All Sexes
This study is evaluating whether a device can help lower blood pressure in people with high blood pressure.
Phase-Based Estimates
1
Effectiveness
1
Safety
Problem List Suggestion
for Anemia, Sickle Cell
Portland, OR
18+
All Sexes
Waitlist Available
Portland, OR
18+
All Sexes
This study is evaluating whether a set of algorithms and decision support tools can improve the quality of care for patients with heart, lung and blood conditions.
Phase-Based Estimates
1
Effectiveness
1
Safety
Acupuncture
for Hypertension
Chesterfield, MO
18+
All Sexes
Phase 1 & 2
Waitlist Available
Chesterfield, MO
18+
All Sexes
This study is evaluating whether acupuncture can be used to treat high blood pressure.
Phase-Based Estimates
1
Effectiveness
2
Safety
ION904
for Hypertension
Cypress, CA
18+
All Sexes
Phase 2
Recruiting
Cypress, CA
18+
All Sexes
The purpose of this study is to evaluate the effect of ION904 on plasma angiotensinogen (AGT) in participants with uncontrolled hypertension.
Phase-Based Estimates
1
Effectiveness
1
Safety
OPTIMA-BP Intervention
for Self-Management
Cleveland, OH
18+
All Sexes
Recruiting
Cleveland, OH
18+
All Sexes
Hypertension (HTN) has a greater impact on African Americans (AA) than any other U.S. racial group. Uncontrolled blood pressure (BP) contributes to higher rates of disability, death, and health resource use among AA. HTN is the single most influential risk factor for cardiovascular disease (CVD), as well as a risk factor for the incidence of stroke, diabetes, chronic kidney disease, and dementia. Importantly, older adults account for 15% of the U.S. population, and two-thirds of older adults over age 60 have HTN, with higher rates observed in AA older adults. Strategies to support self-managing HTN and BP control are crucial as the older population is projected to age considerably and become more racially and ethnically diverse. Research has documented the negative effects on health and health outcomes of poorly controlled BP and is one of the most important modifiable CVD risk factors. Lower BP targets will require aggressive management and an increase in antihypertensive medications. Therefore, to achieve lower targets in this population, greater efforts, including patient-centered methods will be needed to support self-managing HTN, especially in terms of medication adherence. As we shifted into the digital age, the use of mHealth technologies (smart phones, applications, SMS or text messaging) has been a powerful approach and mechanism for the treatment and management of chronic diseases. However, behavioral interventions that incorporate technology do not reach minorities or disadvantaged AA older adults with HTN. OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP) will leverage existing knowledge of effective technology-based components for HTN self-management to support and improve BP control using unique aspects of mHealth platforms in AA older adults. Findings from this study, if confirmed, will improve BP control and support self-managing HTN, as well as has the potential to close the health disparity gap between AA and non-AA older adults with HTN.
Phase-Based Estimates
1
Effectiveness
1
Safety
Medically-tailored Meals
for Chronic Disease
Akron, OH
18+
All Sexes
Recruiting
Akron, OH
18+
All Sexes
The purpose of this study is to investigate the effect of providing healthy foods and nutrition education on participants' body weight, blood pressure, and average blood sugar level. The healthy food offerings tested in this study will help determine which option is best to improve health outcomes among Cleveland Clinic Akron General patients with chronic conditions. Findings from this study could guide doctors in deciding on appropriate nutrition and dietitian services for Cleveland Clinic patients.
Phase-Based Estimates
1
Effectiveness
1
Safety
High Intensity Interval Training (HIIT) Exercise
for Cognitive Decline
Birmingham, AL
18+
All Sexes
Recruiting
Birmingham, AL
18+
All Sexes
The investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. To test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.
Phase-Based Estimates
1
Effectiveness
1
Safety
CDS Tool Access
for Diabetes Mellitus, Type 2
San Francisco, CA
18+
All Sexes
Waitlist Available
San Francisco, CA
18+
All Sexes
This study is evaluating whether providing care team members with clinical decision support tools can improve outcomes for patients with hypertension and diabetes.
Phase-Based Estimates
1
Effectiveness
1
Safety
Renal Denervation
for Hypertension Resistant To Conventional Therapy
Philadelphia, PA
18+
All Sexes
Recruiting
Philadelphia, PA
18+
All Sexes
TRIO CAP is a non-randomized study designed to allow for continued access to ultrasound renal denervation therapy via the Paradise System, and to allow for the on-going collection of safety and effectiveness data in subjects with uncontrolled hypertension despite the prescription of three or more antihypertensive medications.
Phase-Based Estimates
1
Effectiveness
1
Safety
Inspiratory Muscle Strength Training
for Sleep Apnea Syndromes
Tucson, AZ
18+
All Sexes
Recruiting
Tucson, AZ
18+
All Sexes
This study is evaluating whether a breathing exercise program can improve blood pressure and cardiovascular health in adults with obstructive sleep apnea.
Phase-Based Estimates
1
Effectiveness
1
Safety
Support
for Hypertension
Washington, United States
18+
All Sexes
Recruiting
Washington, United States
18+
All Sexes
This study is evaluating whether a mobile health application can improve health outcomes for black cancer patients.
Phase-Based Estimates
3
Effectiveness
3
Safety
Eplerenone 50mg
for Hypertension
Ann Arbor, MI
18+
All Sexes
Phase 4
Waitlist Available
Stage I
Ann Arbor, MI
18+
All Sexes
This blinded cross-over clinical trial will enroll participants with mild stage 1 hypertension to evaluate whether urinary extracellular transcript abundance predicts response to an mineralocorticoid receptor (MR) antagonist, eplerenone. Eligible participants will have a 2 week wash-in period followed by 4 weeks of treatment with placebo or eplerenone. There will be a 2 week wash out period from study medications and then participants will take the other drug (placebo or eplerenone) for 4 weeks. In addition, participants will also provide urine and blood samples during the trial, have physical assessments, and be monitored for safety.
Phase-Based Estimates
1
Effectiveness
1
Safety
IBPS-Guided Ultrafiltration
for Hypotension
Dallas, TX
18+
All Sexes
Recruiting
Dallas, TX
18+
All Sexes
This study is evaluating whether a new strategy for managing fluid overload during hemodialysis may improve outcomes for patients.
Phase-Based Estimates
1
Effectiveness
1
Safety
CTC Intervention
for Hypertension
Philadelphia, PA
18+
All Sexes
Recruiting
Philadelphia, PA
18+
All Sexes
This study is evaluating whether a text message program may help African-American veterans with high blood pressure.
Phase-Based Estimates
1
Effectiveness
1
Safety
Exercise Training Effect On Hypertension And Gut Dysbiosis
for Hypertension
Greensboro, NC
18 - 65
All Sexes
Recruiting
Stage I
Greensboro, NC
18 - 65
All Sexes
This study is evaluating whether exercise can help improve gut health and blood pressure in African Americans.
Phase-Based Estimates
1
Effectiveness
1
Safety
FAM ACT
for Hypertension
Detroit, MI
18+
All Sexes
Recruiting
Detroit, MI
18+
All Sexes
This study is evaluating whether a program which focuses on the family's role in diabetes management may help improve diabetes management.
Phase-Based Estimates
1
Effectiveness
1
Safety
Multicomponent Intervention
for Hypertension
Biloxi, MS
18+
All Sexes
Recruiting
High Risk
Biloxi, MS
18+
All Sexes
This study is evaluating whether a multifaceted implementation strategy for intensive blood pressure control may help reduce the risk of cardiovascular disease.
Phase-Based Estimates
1
Effectiveness
1
Safety
PACESETTER
for Hypertension
San Francisco, CA
18+
All Sexes
Recruiting
San Francisco, CA
18+
All Sexes
This study is evaluating whether a program which tracks stroke patients and provides them with tailored care may help reduce the risk of stroke.
Phase-Based Estimates
1
Effectiveness
2
Safety
High Phosphate Phase
for Hypertension
Dallas, TX
18+
All Sexes
Phase 2
Recruiting
Stage I
Dallas, TX
18+
All Sexes
This study is evaluating whether a high phosphate diet may lead to high blood pressure.
Phase-Based Estimates
1
Effectiveness
1
Safety
Resistance Training
for Hypertension
Chicago, IL
18 - 65
All Sexes
Recruiting
Chicago, IL
18 - 65
All Sexes
This study is evaluating whether aerobic exercise or resistance training may have positive impacts for individuals with multiple sclerosis.
Phase-Based Estimates
3
Effectiveness
3
Safety
Use Of Blood Pressure Lowering Medication At Bedtime
for Hypertension
Winnipeg, Canada
18+
All Sexes
Phase 4
Waitlist Available
Winnipeg, Canada
18+
All Sexes
This study is evaluating whether a change in the timing of blood pressure lowering medications can improve cardiovascular outcomes in people with hypertension.
Phase-Based Estimates
1
Effectiveness
1
Safety
MI-BP
for Hypertension
Detroit, MI
18+
All Sexes
Recruiting
Detroit, MI
18+
All Sexes
This study is evaluating whether a mobile app may help improve hypertension control in African Americans.
Phase-Based Estimates
1
Effectiveness
1
Safety
Symplicity Spyral™ Multi-electrode Renal Denervation System
for Hypertension
Tallahassee, FL
18+
All Sexes
Waitlist Available
Tallahassee, FL
18+
All Sexes
This study is evaluating whether a surgery which reduces bloodflow in a kidney artery leads to significant blood pressure reduction.
Phase-Based Estimates
1
Effectiveness
1
Safety
Phenylephrine
for Essential Hypertension
Nashville, TN
18 - 65
All Sexes
Phase 1
Waitlist Available
Nashville, TN
18 - 65
All Sexes
This study is evaluating whether a peptide may help reduce blood pressure in individuals with hypertension.
Phase-Based Estimates
1
Effectiveness
1
Safety
Electro-acupuncture Test
for Hypertension
Orange, CA
18+
All Sexes
Recruiting
Orange, CA
18+
All Sexes
This study is evaluating whether electroacupuncture may help lower blood pressure in individuals with hypertension.
Phase-Based Estimates
1
Effectiveness
1
Safety
Re-timing Of Anti-hypertensive Drug
for Kidney Diseases
New Haven, CT
< 65
All Sexes
Waitlist Available
High Risk
New Haven, CT
< 65
All Sexes
This is a pilot, crossover trial in which the investigator will determine if retiming of one anti-hypertensive medication from morning to evening can effectuate normal blood pressure dipping patterns in children and adolescents with chronic kidney disease.
Phase-Based Estimates
1
Effectiveness
1
Safety
Daily Blood Pressure Monitoring
for Stroke (CVA) or TIA
Stanford, CA
18+
All Sexes
Waitlist Available
Stanford, CA
18+
All Sexes
To assess the feasibility and adoptability of DailyDoctor's remote monitoring clinical decision support software tool in helping physicians virtually manage systolic blood pressures among patients with history of stroke or TIA to a target systolic blood pressure (<140 mmHg or a lower target range specified by referring physicians) using remote monitoring and independent clinical judgement.
Phase-Based Estimates
1
Effectiveness
1
Safety
Heart To Heart
for Hypertension
Chicago, IL
18+
All Sexes
Recruiting
Chicago, IL
18+
All Sexes
This is a 12-month behavioral cluster-randomized trial testing a church-based intervention to reduce blood pressure in African Americans with uncontrolled blood pressure.
Phase-Based Estimates
1
Effectiveness
1
Safety
At-home Polysomnography
for Sleep
Portland, OR
18 - 65
All Sexes
Waitlist Available
Portland, OR
18 - 65
All Sexes
This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).
Phase-Based Estimates