Clinical TrialsHypertension Clinical Trials 2022
Reviewed by Michael Gill, B. Sc.
Image of CSRU in New Haven, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

BIO-Z Vs. Finapres Novafor Hypertension

18+
All Sexes
The goal of this study is to test a novel cuffless blood pressure (BP) monitoring device (BIO-Z) within adults with hypertension (high blood pressure) for clinical use. The main questions it aims to answer are: To validate a novel cuffless blood pressure (BP) monitoring device (BIO-Z) within adults with hypertension (high blood pressure) To assess BP monitoring accuracy, against reference BP measurements captured by a Finapres Nova® continuous BP monitoring device in correspondence with blood pressure monitoring devices standards. Researchers will test the device against the Finapres Nova® blood pressure monitoring device.
Waitlist Available
Has No Placebo
CSRUErica Spatz
Image of Michigan State University in East Lansing, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Evening-PMfor Hypertension

18+
Female
The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with your body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.
Waitlist Available
Has No Placebo
Michigan State University
Image of University of Delaware in Newark, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Web-based Storytellingfor Hypertension

18+
All Sexes
Narrative communication (e.g., storytelling) is an approach that has contributed to behavioral change for individuals with conditions such as diabetes, breast cancer, and hypertension. The objective of this study is to conduct a feasibility and pilot study storytelling intervention for African Americans with hypertension. In the feasibility phase 30 African Americans with hypertension will be recruited to view nine patient stories and provide feedback on the effectiveness, usefulness, and satisfaction with the stories. Nine African Americans adults with hypertension were filmed, sharing experiences living with and managing hypertension; including, diet and exercise tips, suggestions for locating healthy foods, and motivational stories about successfully controlling hypertension. During the feasibility phase feedback will also be elicited from the participants about the best approaches for delivering a storytelling intervention, and obtain feedback on the resources and health information that would be helpful to an individual participating in a storytelling intervention. In the pilot study phase, 30 African Americans adults with hypertension will be recruited to participate in a 6-week trial, each week the participants will watch one story and review one module of health information accessible through the study specific website developed for the HBPStories study. Data will be collected at baseline and 6-weeks including systolic and diastolic blood pressure, medication adherence, health behaviors such as diet and physical activity, and psychosocial measures including positive affect and self-efficacy in the management of hypertension.
Recruiting
Has No Placebo
University of Delaware
Image of NYC Department of Health and Mental Hygiene in Queens, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

CDS Plus Practice Facilitationfor Hypertension

18+
All Sexes
Hypertension (HTN) is the most prevalent modifiable risk factor for cardiovascular disease among U.S. adults. Despite a long history of established guidelines to support clinical management, only half of U.S. adults diagnosed with HTN have poorly controlled blood pressure (BP) and medication adherence to proven effective treatment remains suboptimal. Clinical decision support (CDS) has the potential to overcome barriers to delivering guideline-recommended care and improve HTN management. Practice facilitation is a well-demonstrated implementation strategy to support process changes and has the potential to facilitate CDS implementation. Our objective is to rigorously evaluate whether practice facilitation provided in concert with a HTN-focused CDS that incorporates medication adherence results is an effective strategy for scaling and implementing CDS. The investigators will update an existing CDS to incorporate alerts and tools to address medication adherence then randomize 40 small independent primary care practices in New York City to receive either practice facilitation in addition to the CDS or the CDS alone. After a twelve-month intervention period, The investigators will examine the differences in blood pressure control achieved by practices in the CDS plus practice facilitation group versus practices that received the CDS alone
Waitlist Available
Has No Placebo
NYC Department of Health and Mental HygieneDuncan Maru
Image of McGill University Health Centre in Montreal, Canada.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

MedSafer-supplemented Medication Reconciliationfor Type 2 Diabetes Mellitus

18+
All Sexes
Dialysis patients are prescribed an average of 10-12 medications per day, from up to 4-5 different clinicians and have the heaviest pill burden of all chronic conditions given their degree of comorbidity. One strategy for addressing the problem of "medication overload" is through scalable deprescribing interventions. MedSafer is an electronic deprescribing tool that cross-references patient health data with existing deprescribing guidelines and provides a deprescribing report to clinicians to facilitate deprescribing and reducing the burden of polypharmacy. In this study the investigators will test MedSafer on dialysis patients paired with medication reconciliation on an intervention unit compared to a control unit.
Waitlist Available
Has No Placebo
McGill University Health CentreEmily McDonald, MD MSc
Image of Elna Clinic in Saint-Mathieu, Canada.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Vegetarian Ketogenic Dietfor Diabetes Mellitus, Non-Insulin-Dependent

18+
All Sexes
Diabetes is one of the biggest public health challenges of the 21st century because of the costs associated with its management, which are estimated at more than three billion dollars per year in Quebec. This cost has been growing steadily for 20 years now. A person with controlled diabetes mobilizes three times more medical resources than a person without diabetes (Diabetes Quebec, 2009). This amount increases rapidly with the associated complications. Therapeutic carbohydrate restriction (in an omnivorous context) used specifically to control glycemia is being studied more and more, but has never been verified in a vegan context. Some studies show that a vegan diet could be an effective way to help type 2 diabetics (T2DM) to better manage their blood sugar. Thus, it is necessary to question whether these effects can be accentuated in the context of a low or very low carbohydrate diet. Numerous publications have highlighted the role of the gut microbiota in metabolic diseases, including T2DM. Analysis of the microbiome before and after dietary change combined with daily breath testing will tell us more about possible intolerances and the role of the microbiome in T2DM management. Given the novelty of these hypotheses and its absence in the literature, it is relevant to undertake a first pilot project with a smaller number of participants in order to obtain preliminary data that will allow us to define more precisely the research avenues for a subsequent study.
Waitlist Available
Has No Placebo
Elna ClinicAndre MaretteBloomedIn
Image of University of British Columbia in Kelowna, Canada.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Microdoses Of Activityfor Hypertension

Any Age
All Sexes
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also investigate whether breaking up the amount of time patients sit with regular short bouts of walking (5 minutes each hour) at a comfortable pace chosen by the patient can have a positive effect on maintaining the health of their blood vessels. It is hypothesized that blood vessel health will be worse after 3 hours of sitting compared to when the sitting is broken up by short bouts of walking.
Recruiting
Has No Placebo
University of British Columbia
Image of William Osler Health System in Brampton, Canada.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Telemonitoring (Medly MCC)for Diabetes Mellitus

18+
All Sexes
In Canada, 3 out of 4 Canadians aged 65 and older have at least one chronic condition, while 1 in 4 seniors reported having three or more. Caring for complex patients who usually have multiple chronic conditions (MCC) is one of the biggest challenges facing our healthcare system. For patients, the lack of coordination and continuity of care as they transfer between healthcare settings and healthcare providers (HCPs) often results in a higher risk of readmission, suboptimal and fragmented care plans, delays in required medical intervention, inadequate self-care, and confusion on whom they should contact when they have questions. For the patient's care team, they often have no indication how patients are doing between clinic visits unless the patient can provide a log of their home measurements (e.g., blood pressure). Therefore, they are unable to detect and intervene if their patient's health is worsening between visits. In order to address this increasing need to bridge the current gap in clinical management and self-care of complex patients during their transition from healthcare settings to home care, our team aims to design, implement and evaluate the SMaRT (Safe, Managed, and Responsive Transitions) Clinic, a nurse-led integrated care model facilitated by telemonitoring (TM). Specifically, the SMaRT Clinics aim to meaningfully introduce a nurse (or nurse practitioner) role to improve clinical coordination across patient care teams and reinforce proper self-care education through the use of telemonitoring. This project will be conducted in two phases across four years; Phase I: Design and Development, and Phase II: Implementation and Effectiveness Evaluation. Phase II research activities include enrolling 350 patients with complex chronic conditions in the SMaRT clinics across four study sites. The implementation and effectiveness of the SMaRT clinics will be evaluated through a mix of semi-structured interviews, ethnographic observation, patient questionnaires, and analyses of health utilization outcomes using propensity-matched controls from the ICES provincial database.
Recruiting
Has No Placebo
William Osler Health System (+3 Sites)
Image of UAMS East - Helena in Helena, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Educational Sessions Plus A Nutrition Box And Recipesfor Obesity

18+
All Sexes
This pilot study seeks to recruit 25 participants who meet program criteria by alleviating chronic morbidities that plague this region by providing participants with nutritional food boxes partnered with nutrition education classes to determine impact and potential benefits of using food as medicine. The key measures seeking to be examined in the program are reducing food insecurity, healthy food consumption, increased nutrition education, and a decrease in biometrics such as hypertension, A1C levels, hyperlipidemia indices, and obesity. UAMS East seeks to alleviate chronic morbidities and food insecurity by launching a food-as-medicine program called The Good Food Rx. The Good Food Rx Program couples established nutrition education classes participation with, at the same time, providing healthy curated nutritional food boxes to at-risk individuals.
Recruiting
Has No Placebo
UAMS East - HelenaAmber K Norris, MD
Image of Cleveland Clinic in Lakewood, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Self-monitoring And Education Program For Lifestyle Changesfor Hypertension

18+
All Sexes
The goal of this single group pre-post-study is to test the possibility of self-monitoring with shared medical appointments program for lifestyle education in improving blood pressure (BP) of patients with uncontrolled hypertension. The main questions it aims to address is: To assess if patients with uncontrolled hypertension and their physicians will be interested in trying a program that includes self-monitoring with 6-week support for lifestyle changes and coping skills to improve BP and hypertension control. To assess if patients with uncontrolled hypertension can safely participate in a program that includes self-monitoring with 6-week support for lifestyle changes and coping skills to improve their BP and ability to self-manage hypertension Participants will: Send self-reports of their home BPs, diet, physical activity and emotions Attend 6-week education program of lifestyle changes and coping skills delivered by physicians, holistic psychotherapists and yoga therapists.
Recruiting
Has No Placebo
Cleveland ClinicSonal J Patil, MD, MSPH
25 Hypertension Clinical Trials Near Me
Top Hospitals for Hypertension Clinical Trials
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Boston
32Active Trials
Brigham and Women's HospitalTop Active Site
Hypertension Clinical Trials by Phase of Trial
Phase < 1 Hypertension Clinical Trials
6Active Hypertension Clinical Trials
6Number of Unique Treatments
6Number of Active Locations
Neuropeptide YAngiotensin-(1-7)CandesartanAscorbic acidHydrochlorothiazide 12.5mgExperimental: Nitrate-containing
Hypertension Clinical Trials by Age Group
< 18 Hypertension Clinical Trials
4Active Hypertension Clinical Trials
PedsBP CDSTreatment group - activeselexipag (Uptravi)Macitentan