Exercise Program for Atrial Fibrillation and Heart Failure
(PREACTIVE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for AF-HFpEF patients, yet effective strategies to address this issue remain limited. While exercise interventions targeting aerobic training (AT) are recommended for patients with AF and HFpEF, unique challenges exist in this patient population who tend to be older. Specifically, many older patients with AF and HFpEF have muscle weakness, sarcopenia and frailty, that can make aerobic-focused exercise difficult and less tolerable. This study proposes that starting with progressive resistance training (PRT) before aerobic exercise may overcome these issues by improving muscle strength, making AT more manageable, and leading to better health outcomes. The goal of this study is to assess whether a sequential exercise program, named 'PREACTIVE' improves how people feel, decrease the amount of symptoms, and their ability to participate in exercise and activities.
This study will specifically test a sequenced exercise approach of resistance training followed by aerobic exercise to improve symptoms, and quality of life in AF-HFpEF.
Who Is on the Research Team?
Deepika Laddu, PhD
Principal Investigator
Northwestern University
Are You a Good Fit for This Trial?
This trial is for older adults with atrial fibrillation and heart failure who have a normal or near-normal ejection fraction, signs of high left ventricular filling pressures on an echocardiogram, and a high risk score for heart failure. Participants should be medically stable and capable of starting an exercise program.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Phase I: Progressive Resistance Training
Participants engage in progressive resistance training to optimize gains in muscle mass and strength, neuromuscular function, and hemodynamic gains
Phase II: Aerobic Endurance Training
Participants focus on aerobic endurance training and an abbreviated version of progressive resistance training
Follow-up
Participants are monitored for safety and effectiveness after the intervention
What Are the Treatments Tested in This Trial?
Interventions
- PREACTIVE
Trial Overview
The PREACTIVE study tests whether beginning with progressive resistance training (strength exercises) before moving to aerobic activities (like walking or cycling) can improve symptoms, quality of life, muscle strength, and the ability to engage in daily activities for those with AF-HFpEF.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
During Phase I participants will engage first in progressive resistance training only (3 sessions/week; 24 sessions total) to optimize gains in muscle mass and strength, neuromuscular function, and hemodynamic gains. Phase II includes 8 weeks that focus on aerobic endurance training and also an abbreviated version of PRT (3 sessions/week; 24 sessions total).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
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