Propofol for Anesthesia
Trial Summary
Do I need to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. However, it does mention that participants should not have a history of drug use or a positive drug screen, and must abstain from alcohol for 24 hours before dosing.
What data supports the effectiveness of the treatment Ultrasonic Brain Stimulation when used with propofol for anesthesia?
Research shows that propofol, a drug used for anesthesia, affects brain activity by enhancing certain inhibitory signals, which helps induce sedation. This suggests that propofol can effectively facilitate the desired state of unconsciousness during procedures, potentially supporting its use in combination with other treatments like Ultrasonic Brain Stimulation.12345
Is propofol generally safe for use in humans?
Propofol is generally considered safe for use in humans, with a well-established safety profile. However, it can cause some side effects like low blood pressure and breathing issues, especially in children and during long procedures. The FDA has warned about potential risks to brain development in young children and pregnant women when exposed to propofol for extended periods.678910
How does the drug propofol differ from other anesthesia treatments?
Propofol is unique because it can be delivered noninvasively using nanoparticles that release the drug when activated by focused ultrasound, allowing for targeted brain modulation without opening the blood-brain barrier or causing damage. This method offers a novel approach compared to traditional intravenous administration of propofol for anesthesia.311121314
What is the purpose of this trial?
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness.Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for use in healthy volunteers.
Research Team
Zirui Huang
Principal Investigator
University of Michigan
Eligibility Criteria
This trial is for individuals undergoing anesthesia with propofol, a common sedative. It's not for healthy volunteers since propofol isn't approved for them. Participants will have their brain activity monitored using fMRI to understand mental function at different anesthesia levels.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Anesthetic Sedation
Participants undergo anesthetic sedation with propofol to study mental function and perception during different levels of anesthesia
Image Recognition Task
Participants perform an image recognition task with real and scrambled images to assess neural response during sedation
Follow-up
Participants are monitored for safety and effectiveness after the anesthetic sedation
Treatment Details
Interventions
- Ultrasonic Brain Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator