Triamcinolone Acetonide for Asthma in Children

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Emory Children's Center, Atlanta, GA
Asthma in Children+2 More
Triamcinolone Acetonide - Drug
Eligibility
< 65
All Sexes
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Study Summary

This study is evaluating whether a steroid injection may help reduce asthma symptoms.

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Eligible Conditions

  • Asthma in Children

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Triamcinolone Acetonide will improve 1 primary outcome and 1 secondary outcome in patients with Asthma in Children. Measurement will happen over the course of Baseline, Week 2.

Baseline, Week 2
Change in Asthma Control Questionnaire (ACQ) Score
Week 16
Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Asthma Impact Scale (PAIS)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Children receiving triamcinolone acetonide
1 of 1
Experimental Treatment

This trial requires 173 total participants across 1 different treatment group

This trial involves a single treatment. Triamcinolone Acetonide is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Children receiving triamcinolone acetonide
Drug
Pediatric participants with exacerbation-prone asthma will receive an intramuscular injection of triamcinolone acetonide and will be followed for 48 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Triamcinolone
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: weeks 16, 32, and 48
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly weeks 16, 32, and 48 for reporting.

Who is running the study

Principal Investigator
A. M. F.
Prof. Anne M Fitzpatrick, Associate Professor
Emory University

Closest Location

Emory Children's Center - Atlanta, GA

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Age 6 to less than 21 years at the enrollment visit
Physician diagnosis of asthma
Treatment with systemic corticosteroids, or Increase in rescue medication use (i.e., albuterol or inhaled corticosteroid) for 24 hours or more, or One or more missed school days due to asthma symptoms, or An unscheduled visit for asthma at either a physician's office, urgent care, hospital emergency room, or Hospitalization for asthma.
In the event of a recent exacerbation treated with systemic corticosteroids or requiring hospitalization, the first study visit will be postponed until two weeks after the last dose of systemic corticosteroids (i.e., prednisone or prednisolone).

Patient Q&A Section

What is triamcinolone acetonide?

"This is an effective, well-tolerated steroid in children. This is the first report of a nonhormonal effect in children with moderate-to-severe atopic dermatitis and asthma." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of asthma?

"The environmental factor, with its influence on the asthma, is the most important cause, followed by genetic factors and then by allergies when assessed according to the pathogenesis model." - Anonymous Online Contributor

Unverified Answer

How many people get asthma a year in the United States?

"For some people, a year out of everyone with asthma is a mild illness or none at all. However for others it is a major issue." - Anonymous Online Contributor

Unverified Answer

What is asthma?

"Asthma is mainly a chronic lung disorder, and it may affect the whole body. Asthma includes shortness of breath in the lungs, frequent nighttime cough, wheezing, chest tightness and chest pain in an occasional circumstances. It may also lead to chronic bronchitis, impaired lung function, asthma attacks due to shortness of breath and/or wheezing in the past 12 months." - Anonymous Online Contributor

Unverified Answer

Can asthma be cured?

"While it is unclear to what degree the symptoms will disappear, there is some evidence that symptoms occur from a number of different causes and that they tend to be temporary. The most promising findings that asthma can be cured is that it can be effectively treated." - Anonymous Online Contributor

Unverified Answer

What causes asthma?

"Asthma is a combination of several known and many unknown causes. The most common causes of wheezing are allergic reactions and cigarette smoking, but other factors may also increase the risk, such as family history, allergy to dust and animals, and other environmental factors (e.g. cockroaches)." - Anonymous Online Contributor

Unverified Answer

What are the signs of asthma?

"Symptoms include wheezing, shortness of breath, chest tightness, coughing, fatigue, exercise intolerance, chest pain, fever and nose bleeds. It involves the bronchial passages and airways.\n" - Anonymous Online Contributor

Unverified Answer

Does asthma run in families?

"The family history of the mother of an asthmatic patient appeared to have a small effect in predicting the occurrence of asthma (0.17 in this study), but it should be taken into account when the patient is counseled regarding risk factors for asthma or preventive strategies." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating asthma?

"Our experience points out that it is difficult to determine what works and what doesn’t. It is necessary for patients with asthma to be referred to different specialist physicians who can manage their conditions. If there is a serious breathing problem, referral needs to be made to an allopathic specialist because of the complexity of this disorder which may involve several pathophysiological processes and treatment needs a multifactorial approach." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of triamcinolone acetonide?

"Common side effects of intravitreal triamcinolone acetonide include inflammation and ocular changes, including swollen eyes. Intravitreal injections are not a risk factor for glaucoma when proper techniques are used." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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