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Antibiotic Stewardship

INSPIRE Stewardship Bundle for Abdominal Infection

Fairview Park Hospital, Dublin, GA
Arm 1: Routine Care +1 moreN/ARecruitingLed by Susan Huang, MD, MPHResearch Sponsored by Harvard Pilgrim Health Care

Study Summary

This trial is comparing the routine use of antibiotics with real-time, precision medicine computerized physician order entry (CPOE) smart prompts in order to reduce the probability that a non-critically ill adult admitted with abdominal infection is infected with a resistant pathogen.

Eligible Conditions
  • Abdominal Infection

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Empiric Extended-Spectrum Days of Therapy (Empiric ES-DOT)
Secondary outcome measures
Antipseudomonal Antibiotic Days of Therapy per Empiric Day
Vancomycin Days of Therapy per Empiric Day
Other outcome measures
Empiric and Total Antibiotic Costs
Therapeutic procedure
Incidence of Hospital-Onset C. difficile
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Arm 1: Routine CareActive Control1 Intervention
Continuation of routine antibiotic stewardship strategies.
Group II: Arm 2: INSPIRE Stewardship BundleActive Control1 Intervention
Use of computerized physician order entry (CPOE) smart prompts, clinician feedback, and activities to support CPOE adoption (including education and alignment of CPOE workflows) to guide empiric choice of antibiotics for abdominal infection in the first 3 days of hospitalization.

Find a Location

Who is running the clinical trial?

Rush UniversityOTHER
39 Previous Clinical Trials
30,071 Total Patients Enrolled
Harvard Pilgrim Health CareLead Sponsor
54 Previous Clinical Trials
27,429,025 Total Patients Enrolled
HCA Healthcare, IncUNKNOWN
1 Previous Clinical Trials
102 Total Patients Enrolled

Media Library

INSPIRE CPOE Smart Prompt for Abdominal Infection (Antibiotic Stewardship) Clinical Trial Eligibility Overview. Trial Name: NCT05423743 — N/A
Abdominal Infection Research Study Groups: Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle
Abdominal Infection Clinical Trial 2023: INSPIRE CPOE Smart Prompt for Abdominal Infection Highlights & Side Effects. Trial Name: NCT05423743 — N/A
INSPIRE CPOE Smart Prompt for Abdominal Infection (Antibiotic Stewardship) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05423743 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants still being sought for this investigation?

"The clinical trial is currently in search of participants. According to the information posted on clinicaltrials.gov, this study was initially announced on August 2nd 2022 and last updated a month later."

Answered by AI

What is the anticipated participant count for this investigation?

"Indeed, clinicaltrials.gov's data shows that this study is still open for recruitment as of August 29th 2022; the trial was initially published on August 2nd of the same year. 102 individuals are being sought after at 100 medical centres across the country."

Answered by AI

Are there numerous locations administering this experiment in North America?

"There are 100 medical sites that are participating in this research. A few of these include Sky Ridge Medical Center situated in Lone Tree, Wesley Medical Centre located in Wichita and The Medical Center of Aurora found within the city of Aurora."

Answered by AI

Who else is applying?

What state do they live in?
Texas
Florida
What site did they apply to?
Mercy Hospital
St. Lucie Medical Center
St. David's North Austin Medical Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
Recent research and studies
clinicaltrials.govStudy
INSPIRE Trial for Abdominal Infections
Richard Platt 2022. "INSPIRE Trial for Abdominal Infections". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05423743.
All > Utah
~68 spots leftby Dec 2027
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