Coreg

Atrial Fibrillation, Ventricular Dysfunction, Left, Heart failure + 5 more
Treatment
9 FDA approvals
20 Active Studies for Coreg

What is Coreg

CarvedilolThe Generic name of this drug
Treatment SummaryCarvedilol is a combination drug used to treat heart failure, left ventricular dysfunction, and high blood pressure. It works by blocking the action of two types of hormones: beta and alpha-1. Carvedilol has been found to be effective in treating moderate cases of hypertension with fewer side effects than higher doses of single drugs. It was approved by the FDA in 1995.
Coregis the brand name
image of different drug pills on a surface
Coreg Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coreg
Carvedilol
1997
522

Approved as Treatment by the FDA

Carvedilol, commonly known as Coreg, is approved by the FDA for 9 uses such as Heart failure and Ventricular Dysfunction, Left .
Heart failure
Helps manage NYHA Class I or II heart failure
Ventricular Dysfunction, Left
Helps manage LVEF ≤40% Left ventricular dysfunction
chronic heart failure with reduced ejection fraction (NYHA Class IV)
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
NYHA Class I or II heart failure
Helps manage NYHA Class I or II heart failure
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
LVEF ≤40% Left ventricular dysfunction
Helps manage LVEF ≤40% Left ventricular dysfunction
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Heart Attack
Helps manage Myocardial Infarction

Effectiveness

How Coreg Affects PatientsCarvedilol is a drug used to reduce a rapid heart rate and lower blood pressure. It needs to be taken once a day and is usually given in doses of 10-80mg. It's important to not stop taking carvedilol suddenly, as this can worsen coronary artery disease.
How Coreg works in the bodyCarvedilol reduces heart rate and blood pressure by blocking signals sent to the heart and blood vessels by the sympathetic nervous system. It also has antioxidant properties, which can help prevent cholesterol from building up in the heart.

When to interrupt dosage

The prescribed dosage of Coreg is contingent upon the diagnosed state, including Chronic Stable Angina Pectoris, Ventricular Dysfunction, Left and Hypesthesia. The amount of dosage varies, based on the administration method denoted in the table below.
Condition
Dosage
Administration
Atrial Fibrillation
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Ventricular Dysfunction, Left
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Heart failure
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Heart Attack
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Angina, Stable
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit

Warnings

Coreg has nine contra-indications and its utilization should be avoided in combination with the situations specified in the table below.Coreg Contraindications
Condition
Risk Level
Notes
Bronchospasm
Do Not Combine
Asthma
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Therapeutic procedure
Do Not Combine
Therapeutic procedure
Do Not Combine
severe bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carvedilol may interact with Pulse Frequency
There are 20 known major drug interactions with Coreg.
Common Coreg Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Carvedilol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Carvedilol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Carvedilol.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.
Acepromazine
Major
Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Coreg Toxicity & Overdose RiskThose who overdose on the drug may have low blood pressure, slow heartbeats, heart problems, and even cardiac arrest. The patient should be placed in a lying position and can be given atropine for slow heartbeats and glucagon with sympathomimetics to support the cardiovascular system.
image of a doctor in a lab doing drug, clinical research

Coreg Novel Uses: Which Conditions Have a Clinical Trial Featuring Coreg?

253 active clinical trials are being conducted to assess the potential of Coreg in providing relief for Hypesthesia, Heart failure and Hypesthesia.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
94 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
23 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Angina, Stable
0 Actively Recruiting
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Heart failure
0 Actively Recruiting
Hypesthesia
4 Actively Recruiting
Not Applicable, Phase 1
Ventricular Dysfunction, Left
0 Actively Recruiting

Coreg Reviews: What are patients saying about Coreg?

5Patient Review
3/25/2018
Coreg for High Blood Pressure
I began taking Coreg at age 58-59. I was prescribed 12.5 mg twice a day, but experienced some side effects in the form of tiredness. This problem was resolved by taking a 20 mg time-released prescription. It's important to note that I only use brand name Coreg; thegeneric version may not be as effective. I also take lisinipril (generic) and an old generic water pill for my blood pressure. The water pill is a big problem because it makes me have to drink more water and avoid salt, but it does bring my blood pressure down well.
5Patient Review
12/17/2019
Coreg for Chronic Heart Failure
I've been on this treatment for two decades and it's really kept me alive and well. I would highly recommend it to others in a similar situation as me.
5Patient Review
7/25/2019
Coreg for Chronic Heart Failure
Coreg has been a lifesaver for me since I was diagnosed with heart failure post chemotherapy. My dose is low, at 6.25 mg twice a day, but it keeps my blood pressure in check and has helped me manage my symptoms effectively.
5Patient Review
12/17/2019
Coreg for Chronic Heart Failure
I've been taking this medication for 20 years now and it's really kept me going. I don't know how I would have fared without it, but I'm grateful that it hasn't caused any organ damage.
5Patient Review
10/14/2017
Coreg for High Blood Pressure
I had no issues with this treatment. My blood pressure is now more stable than ever.
4.7Patient Review
11/19/2017
Coreg for Chronic Heart Failure
Though there are some not-so-fun side effects that come with this treatment, they pale in comparison to how well it's worked for me. I was diagnosed in 2003 and am still going strong!
2.7Patient Review
12/31/2018
Coreg for High Blood Pressure
After taking Carvedilol for 9 years, I have now been diagnosed with stage 3 kidney disease. I believe it is this medication that has caused this medical problem. My nephologist has cut my pills from two per day to 1/2 twice a day. I want off of Carvedilol as it has ruined my life.
2.3Patient Review
8/15/2016
Coreg for High Blood Pressure
I have only taken carvedilol for 3 days and I have my head and chest pound when I get up or it is near time for the next dose. I have had a non-stop headache, nausea and a metallic taste in my mouth. I will give it til Friday for improvement. If none I will talk to my doctor about changing.
2Patient Review
2/5/2017
Coreg for High Blood Pressure
I experienced fatigue, dizziness and headaches. I also started to notice tenderness in my gums and nasal passages.
1.7Patient Review
2/29/2016
Coreg for High Blood Pressure
Just a week in and I am already feeling the adverse effects of this medication. I'm exhausted, my mouth is blistered and swollen, and my head hurts. My pupils are so dilated that it's hard to see. I also have no control over my bladder and I'm sore all over. This has been miserable.
1.7Patient Review
12/7/2018
Coreg for High Blood Pressure
I experienced intense exhaustion, swelling of legs, and extreme difficulty breathing while on this medication. I also lost sleep due to my breathing difficulties, which led to body pain and depression. My thinking was also very unclear, and I felt anxious all the time. This drug was a nightmare for me.
1.7Patient Review
2/27/2017
Coreg for High Blood Pressure
I'm always tired and unable to focus while on this medication, which is not worth the benefit in my opinion.
1Patient Review
2/18/2017
Coreg for Chronic Heart Failure
This drug is terrible. My mother was sent home from the hospital with it, and after the first dose she developed shortness of breath and a violent cough. It was so bad that she couldn't breathe, and I thought we were going to lose her.
1Patient Review
7/9/2017
Coreg for High Blood Pressure
I felt really exhausted after taking this, to the point where it was hard to focus or think clearly. I also had a lot of trouble sleeping, and my knee joints started hurting pretty badly.
1Patient Review
11/6/2020
Coreg for High Blood Pressure
After only taking this medication for three days, my blood pressure spiked to an incredibly dangerous level. I had to go to the ER and get a bunch of tests done. The only conclusion was that I shouldn't take this drug again, and I definitely won't be.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about coreg

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Coreg a good blood pressure medication?

"Carvedilol, sold under the brand name Coreg among others, is a medication used for treating high blood pressure, heart failure, and left ventricular dysfunction."

Answered by AI

What is the drug Coreg used for?

"Carvedilol is used to treat high blood pressure and heart failure. It can also be used after a heart attack to improve the chances of survival if your heart isn't pumping well. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems."

Answered by AI

What are the most common side effects of carvedilol?

"If you experience any of the following symptoms, you may be allergic to the medication: chest pain, discomfort, tightness, or heaviness; dizziness, lightheadedness, or fainting; generalized swelling or swelling of the feet, ankles, or lower legs; pain; shortness of breath; slow heartbeat; weight gain."

Answered by AI

What are the side effects of taking Coreg?

"Coreg may have a number of serious side effects, including low blood pressure, chest pain, an irregular heartbeat, difficulty breathing and swallowing, hives or a rash, swelling, and fainting. People with liver problems should not take Coreg."

Answered by AI

Clinical Trials for Coreg

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Coreg clinical trials? We made a collection of clinical trials featuring Coreg, we think they might fit your search criteria.Go to Trials
Image of Mission Cardiovascular Research Institute in Fremont, United States.

REGN7508 + REGN9933 for Atrial Fibrillation

18+
All Sexes
Fremont, CA
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Phase 2
Recruiting
Mission Cardiovascular Research Institute (+4 Sites)Clinical Trial ManagementRegeneron Pharmaceuticals
Image of St Boniface Hospital in Winnipeg, Canada.

Remote Home Monitoring for Heart Attack

18+
All Sexes
Winnipeg, Canada
Heart attacks are one of the top causes of death in Canada, with over 2,100 cases treated each year in Manitoba. Even though hospital care has improved, the period after going home is still risky. Many patients feel anxious and unsure about their recovery, and without enough support, they often end up back in the emergency department (ED). This is an even bigger challenge for people in rural areas, where getting follow-up care can be much harder. Filling these gaps is important to help patients get better and to reduce stress on the healthcare system. In a previous study, the investigators found that extra support made a big difference: only 8% of participants using a digital health tool returned to the ED within 30 days, compared to 22% of participants without it. Now, the investigators want to expand this study across Manitoba to see if digital health tools can help more people recover safely at home. The investigators will compare two types of follow-up care: education only versus education with extra support (like symptom tracking and virtual appointments). The investigators will look at how this affects hospital visits, mental well-being, and healthcare costs. The goal is to create a better support system for people after a heart attack, leading to healthier recoveries, less strain on hospitals, and better care for Manitobans - no matter where they live.
Waitlist Available
Has No Placebo
St Boniface Hospital
Have you considered Coreg clinical trials? We made a collection of clinical trials featuring Coreg, we think they might fit your search criteria.Go to Trials
Image of Baystate Medical Center in Springfield, United States.

Consent Approaches for Heart Disease Rehabilitation

18+
All Sexes
Springfield, MA
Cardiac Rehabilitation is a lifestyle and exercise program for patients with heart disease. Cardiac Rehabilitation is strongly recommended in guidelines, but only 30% of eligible patients attend. New strategies are needed to help more patients attend cardiac rehabilitation. In this study, the investigators will see if using an $50 incentive, case management, text messages, and physical activity coaching combined into a single intervention will help more patients attend cardiac rehabilitation. In preparation for a larger trial, patients will also be randomly assigned to four different ways of seeking their permission to be in a research study. The investigators will see if these approaches affect how many people participate in the research project. The two main goals of this study is to understand: 1. If the consent approach type impacts participation rates in the research study 2. If the multi-component intervention (case management, financial incentives, text messages, and physical activity coaching) improves cardiac rehabilitation participation within 3 months.
Recruiting
Has No Placebo
Baystate Medical CenterQuinn R Pack, MD, MSc
Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Coreg clinical trials? We made a collection of clinical trials featuring Coreg, we think they might fit your search criteria.Go to Trials
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