Carvedilol

Atrial Fibrillation, Ventricular Dysfunction, Left, Heart failure + 5 more
Treatment
9 FDA approvals
20 Active Studies for Carvedilol

What is Carvedilol

CarvedilolThe Generic name of this drug
Treatment SummaryCarvedilol is a medication used to treat heart failure, left ventricular dysfunction, and high blood pressure. It works by blocking the action of certain hormones in the body that can cause the heart rate to increase. Carvedilol is unique in that it is a combination of two drugs, which can be used together to reduce the risk of side effects compared to using a single high-dose drug. Carvedilol was approved by the FDA in 1995.
Coregis the brand name
image of different drug pills on a surface
Carvedilol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coreg
Carvedilol
1997
522

Approved as Treatment by the FDA

Carvedilol, commonly known as Coreg, is approved by the FDA for 9 uses such as Heart failure and Ventricular Dysfunction, Left .
Heart failure
Helps manage NYHA Class I or II heart failure
Ventricular Dysfunction, Left
Helps manage LVEF ≤40% Left ventricular dysfunction
chronic heart failure with reduced ejection fraction (NYHA Class IV)
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
NYHA Class I or II heart failure
Helps manage NYHA Class I or II heart failure
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
LVEF ≤40% Left ventricular dysfunction
Helps manage LVEF ≤40% Left ventricular dysfunction
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Heart Attack
Helps manage Myocardial Infarction

Effectiveness

How Carvedilol Affects PatientsCarvedilol works by blocking certain hormones that can cause your heart to beat too fast and your blood pressure to rise. It usually needs to be taken once a day and is considered to be safe if taken in the proper dose (10-80mg daily). It is important not to suddenly stop taking it, as this can make existing coronary artery disease worse.
How Carvedilol works in the bodyCarvedilol works to reduce blood pressure by blocking the action of certain receptors that cause constriction of blood vessels. It also helps to prevent the buildup of cholesterol in the arteries. At higher doses, it can also block calcium channels and have an antioxidant effect, which helps protect against cell damage.

When to interrupt dosage

The measure of Carvedilol is contingent upon the detailed state, including Chronic Stable Angina Pectoris, Ventricular Dysfunction, Left and Hypesthesia. The quantity of dosage is contingent upon the delivery approach noted in the following table.
Condition
Dosage
Administration
Atrial Fibrillation
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Ventricular Dysfunction, Left
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Heart failure
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Heart Attack
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Angina, Stable
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral

Warnings

Carvedilol Contraindications
Condition
Risk Level
Notes
Bronchospasm
Do Not Combine
Asthma
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Therapeutic procedure
Do Not Combine
Therapeutic procedure
Do Not Combine
severe bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carvedilol may interact with Pulse Frequency
There are 20 known major drug interactions with Carvedilol.
Common Carvedilol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Carvedilol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Carvedilol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Carvedilol.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.
Acepromazine
Major
Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Carvedilol Toxicity & Overdose RiskAn overdose of the drug can cause low blood pressure, slow heartbeat, heart weakness, shock, and cardiac arrest. Patients should lie down and may be given atropine to raise the heart rate and glucagon and other medicines to help treat the cardiovascular issues.
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Carvedilol Novel Uses: Which Conditions Have a Clinical Trial Featuring Carvedilol?

253 active investigations are investigating the potential of Carvedilol to diminish Hypesthesia, treat Heart failure, and reduce Hypesthesia in affected individuals.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
Heart failure
0 Actively Recruiting
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Ventricular Dysfunction, Left
0 Actively Recruiting

Carvedilol Reviews: What are patients saying about Carvedilol?

4.3Patient Review
8/21/2021
Carvedilol for Prevention of Recurrent Atrial Fibrillation
I've only been taking this medication for a little while, but it has already lowered my blood pressure and slowed down my breathing. I have noticed some drowsiness, but it also allows me to breathe more deeply and without the chest tightness I used to feel. For now, I think the benefits outweigh the drawbacks.
2.7Patient Review
5/3/2021
Carvedilol for High Blood Pressure
I get nose bleeds often and I think it has to do with this blood pressure medication. If anyone else has had a similar experience, please let me know.
2.3Patient Review
4/3/2020
Carvedilol for Chronic Heart Failure
I've been on this medication for a year now, and I keep telling my doctor that it's not good. I'm constantly tired and sweaty, and it's hard to stay awake. I'm going to see the cardiologist again soon to discuss changing or discontinuing the medication so that I can live a better quality life.
2.3Patient Review
2/10/2021
Carvedilol for High Blood Pressure
I have yet to see any significant changes in my blood pressure after taking this medication for two months now.
2Patient Review
11/13/2020
Carvedilol for High Blood Pressure
I was on this medicine for a month at 6.25mg, then my cardiologist increased the dosage to 12.5mg twice daily. I started experiencing severe chest pain, dizziness, and headaches so I will be asking my doctor to change my medication.
View All Reviews
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Patient Q&A Section about carvedilol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a carvedilol used for?

"Carvedilol is a medicine used to treat high blood pressure and prevent angina, heart disease and stroke."

Answered by AI

What are the side effects of carvedilol?

"Allergy, chest pain, discomfort, tightness, heaviness, dizziness, lightheadedness, fainting, generalized swelling, swelling of feet, ankles, lower legs, pain, slow heartbeat, weight gain."

Answered by AI

Is carvedilol a beta-blocker or diuretic?

"The response to carvedilol is not diminished on chronic administration.

Carvedilol is a new antihypertensive agent that blocks beta receptors and also has vasodilating properties due to its alpha 1-blocking activity. This results in reduced peripheral vascular resistance, but cardiac output and renal function are not affected. The response to carvedilol does not decrease over time with continued use."

Answered by AI

Who should not take carvedilol?

"Medical conditions that may cause problems with the electrical signals in the heart include diabetes, myasthenia gravis (a disorder that causes muscle weakness), Prinzmetal angina (a type of chest pain that occurs when at rest), complete heart block, second degree atrioventricular heart block, sick sinus syndrome, and sinus bradycardia (a slow heart rhythm)."

Answered by AI

Clinical Trials for Carvedilol

Have you considered Carvedilol clinical trials? We made a collection of clinical trials featuring Carvedilol, we think they might fit your search criteria.
Have you considered Carvedilol clinical trials? We made a collection of clinical trials featuring Carvedilol, we think they might fit your search criteria.
Have you considered Carvedilol clinical trials? We made a collection of clinical trials featuring Carvedilol, we think they might fit your search criteria.
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