Carvedilol

Atrial Fibrillation, Ventricular Dysfunction, Left, Heart failure + 5 more
Treatment
9 FDA approvals
20 Active Studies for Carvedilol

What is Carvedilol

CarvedilolThe Generic name of this drug
Treatment SummaryCarvedilol is a medication used to treat heart failure, left ventricular dysfunction, and high blood pressure. It works by blocking the action of certain hormones in the body that can cause the heart rate to increase. Carvedilol is unique in that it is a combination of two drugs, which can be used together to reduce the risk of side effects compared to using a single high-dose drug. Carvedilol was approved by the FDA in 1995.
Coregis the brand name
image of different drug pills on a surface
Carvedilol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coreg
Carvedilol
1997
522

Approved as Treatment by the FDA

Carvedilol, commonly known as Coreg, is approved by the FDA for 9 uses such as Heart failure and Ventricular Dysfunction, Left .
Heart failure
Helps manage NYHA Class I or II heart failure
Ventricular Dysfunction, Left
Helps manage LVEF ≤40% Left ventricular dysfunction
chronic heart failure with reduced ejection fraction (NYHA Class IV)
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
NYHA Class I or II heart failure
Helps manage NYHA Class I or II heart failure
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
LVEF ≤40% Left ventricular dysfunction
Helps manage LVEF ≤40% Left ventricular dysfunction
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Heart Attack
Helps manage Myocardial Infarction

Effectiveness

How Carvedilol Affects PatientsCarvedilol works by blocking certain hormones that can cause your heart to beat too fast and your blood pressure to rise. It usually needs to be taken once a day and is considered to be safe if taken in the proper dose (10-80mg daily). It is important not to suddenly stop taking it, as this can make existing coronary artery disease worse.
How Carvedilol works in the bodyCarvedilol works to reduce blood pressure by blocking the action of certain receptors that cause constriction of blood vessels. It also helps to prevent the buildup of cholesterol in the arteries. At higher doses, it can also block calcium channels and have an antioxidant effect, which helps protect against cell damage.

When to interrupt dosage

The measure of Carvedilol is contingent upon the detailed state, including Chronic Stable Angina Pectoris, Ventricular Dysfunction, Left and Hypesthesia. The quantity of dosage is contingent upon the delivery approach noted in the following table.
Condition
Dosage
Administration
Atrial Fibrillation
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Ventricular Dysfunction, Left
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Heart failure
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Heart Attack
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit
Angina, Stable
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Kit

Warnings

Carvedilol Contraindications
Condition
Risk Level
Notes
Bronchospasm
Do Not Combine
Asthma
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Therapeutic procedure
Do Not Combine
Therapeutic procedure
Do Not Combine
severe bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carvedilol may interact with Pulse Frequency
There are 20 known major drug interactions with Carvedilol.
Common Carvedilol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Carvedilol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Carvedilol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Carvedilol.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.
Acepromazine
Major
Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Carvedilol Toxicity & Overdose RiskAn overdose of the drug can cause low blood pressure, slow heartbeat, heart weakness, shock, and cardiac arrest. Patients should lie down and may be given atropine to raise the heart rate and glucagon and other medicines to help treat the cardiovascular issues.
image of a doctor in a lab doing drug, clinical research

Carvedilol Novel Uses: Which Conditions Have a Clinical Trial Featuring Carvedilol?

253 active investigations are investigating the potential of Carvedilol to diminish Hypesthesia, treat Heart failure, and reduce Hypesthesia in affected individuals.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
95 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Hypertensive disease
28 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
23 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Angina, Stable
0 Actively Recruiting
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Heart failure
0 Actively Recruiting
Hypesthesia
6 Actively Recruiting
Not Applicable, Phase 1, Phase 4
Ventricular Dysfunction, Left
0 Actively Recruiting

Carvedilol Reviews: What are patients saying about Carvedilol?

4.3Patient Review
8/21/2021
Carvedilol for Prevention of Recurrent Atrial Fibrillation
I've only been taking this medication for a little while, but it has already lowered my blood pressure and slowed down my breathing. I have noticed some drowsiness, but it also allows me to breathe more deeply and without the chest tightness I used to feel. For now, I think the benefits outweigh the drawbacks.
2.7Patient Review
5/3/2021
Carvedilol for High Blood Pressure
I get nose bleeds often and I think it has to do with this blood pressure medication. If anyone else has had a similar experience, please let me know.
2.3Patient Review
4/3/2020
Carvedilol for Chronic Heart Failure
I've been on this medication for a year now, and I keep telling my doctor that it's not good. I'm constantly tired and sweaty, and it's hard to stay awake. I'm going to see the cardiologist again soon to discuss changing or discontinuing the medication so that I can live a better quality life.
2.3Patient Review
2/10/2021
Carvedilol for High Blood Pressure
I have yet to see any significant changes in my blood pressure after taking this medication for two months now.
2Patient Review
11/13/2020
Carvedilol for High Blood Pressure
I was on this medicine for a month at 6.25mg, then my cardiologist increased the dosage to 12.5mg twice daily. I started experiencing severe chest pain, dizziness, and headaches so I will be asking my doctor to change my medication.
1.7Patient Review
4/13/2022
Carvedilol for Dysfunction of Left Ventricle of Heart following Heart Attack
I had to stop taking this drug after just two weeks because the side effects were so extreme. I was constantly dizzy, having trouble breathing, and my mouth was always dry. My blood pressure was also very low. If you have any chronic health conditions, I would not recommend this drug.
1.7Patient Review
10/27/2022
Carvedilol for High Blood Pressure
After my second dose of 3.125mg, I felt an overwhelming sense of anger which was quickly followed by sadness and depression. I had suicidal and homicidal thoughts.
1.3Patient Review
5/12/2021
Carvedilol for Prevention of Recurrent Atrial Fibrillation
I'm really tired of feeling this way. I hate how it makes my skin feel, and I'm cold all the time. I just want to be off of it.
1Patient Review
8/5/2021
Carvedilol for High Blood Pressure
I was prescribed this pill and have been taking it for two years now. I'm constantly tired and wheeze regularly. My mom was also prescribed this pill and she used to be exhausted all the time; she even died as a result of exhaustion-related falls. I spoke to a pharmacist about my concerns and they told me not to take the pill anymore and to consult with a doctor who actually cares.
1Patient Review
3/18/2022
Carvedilol for High Blood Pressure
I started taking this medication on September 21st at a dose of 6.25mg. Unfortunately, that wasn't enough and my cardiologist put me up to 12.25mg. I then dropped back down to 6.25mg and my blood pressure is good now. However, I experienced a lot of side effects like dizziness, tiredness, fluid retention, weight gain, shortness of breath, etc. My advice is to make sure you have an excellent PCP and cardiologist before starting this journey.
1Patient Review
1/9/2022
Carvedilol for Prevention of Recurrent Atrial Fibrillation
I'm Asian and I started taking this medication in September of 2020 to help with my heart palpitations. While it did lower the palpitation, I started experiencing dizziness, muscle pain, and blurry vision by November. This was the only new medication I was taking at the time, so I'm confident that it was the cause. I stopped taking it a few days ago, and while the dizziness is more manageable now, it still comes and goes.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about carvedilol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a carvedilol used for?

"Carvedilol is a medicine used to treat high blood pressure and prevent angina, heart disease and stroke."

Answered by AI

What are the side effects of carvedilol?

"Allergy, chest pain, discomfort, tightness, heaviness, dizziness, lightheadedness, fainting, generalized swelling, swelling of feet, ankles, lower legs, pain, slow heartbeat, weight gain."

Answered by AI

Is carvedilol a beta-blocker or diuretic?

"The response to carvedilol is not diminished on chronic administration.

Carvedilol is a new antihypertensive agent that blocks beta receptors and also has vasodilating properties due to its alpha 1-blocking activity. This results in reduced peripheral vascular resistance, but cardiac output and renal function are not affected. The response to carvedilol does not decrease over time with continued use."

Answered by AI

Who should not take carvedilol?

"Medical conditions that may cause problems with the electrical signals in the heart include diabetes, myasthenia gravis (a disorder that causes muscle weakness), Prinzmetal angina (a type of chest pain that occurs when at rest), complete heart block, second degree atrioventricular heart block, sick sinus syndrome, and sinus bradycardia (a slow heart rhythm)."

Answered by AI

Clinical Trials for Carvedilol

Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA
The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.
Phase 4
Waitlist Available
Inova Alexandria Hospital
Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Carvedilol clinical trials? We made a collection of clinical trials featuring Carvedilol, we think they might fit your search criteria.Go to Trials
Have you considered Carvedilol clinical trials? We made a collection of clinical trials featuring Carvedilol, we think they might fit your search criteria.Go to Trials
Image of St Boniface Hospital in Winnipeg, Canada.

Remote Home Monitoring for Heart Attack

18+
All Sexes
Winnipeg, Canada
Heart attacks are one of the top causes of death in Canada, with over 2,100 cases treated each year in Manitoba. Even though hospital care has improved, the period after going home is still risky. Many patients feel anxious and unsure about their recovery, and without enough support, they often end up back in the emergency department (ED). This is an even bigger challenge for people in rural areas, where getting follow-up care can be much harder. Filling these gaps is important to help patients get better and to reduce stress on the healthcare system. In a previous study, the investigators found that extra support made a big difference: only 8% of participants using a digital health tool returned to the ED within 30 days, compared to 22% of participants without it. Now, the investigators want to expand this study across Manitoba to see if digital health tools can help more people recover safely at home. The investigators will compare two types of follow-up care: education only versus education with extra support (like symptom tracking and virtual appointments). The investigators will look at how this affects hospital visits, mental well-being, and healthcare costs. The goal is to create a better support system for people after a heart attack, leading to healthier recoveries, less strain on hospitals, and better care for Manitobans - no matter where they live.
Waitlist Available
Has No Placebo
St Boniface Hospital
Image of Baystate Medical Center in Springfield, United States.

Consent Approaches for Heart Disease Rehabilitation

18+
All Sexes
Springfield, MA
Cardiac Rehabilitation is a lifestyle and exercise program for patients with heart disease. Cardiac Rehabilitation is strongly recommended in guidelines, but only 30% of eligible patients attend. New strategies are needed to help more patients attend cardiac rehabilitation. In this study, the investigators will see if using an $50 incentive, case management, text messages, and physical activity coaching combined into a single intervention will help more patients attend cardiac rehabilitation. In preparation for a larger trial, patients will also be randomly assigned to four different ways of seeking their permission to be in a research study. The investigators will see if these approaches affect how many people participate in the research project. The two main goals of this study is to understand: 1. If the consent approach type impacts participation rates in the research study 2. If the multi-component intervention (case management, financial incentives, text messages, and physical activity coaching) improves cardiac rehabilitation participation within 3 months.
Waitlist Available
Has No Placebo
Baystate Medical CenterQuinn R Pack, MD, MSc
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