5-Fluorouracil Injection for Chalazion
(CTS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial compares different treatments for eyelid lumps called chalazia. The treatments include medicine injections or minor surgery. The goal is to see which method best reduces or removes these lumps. Injections have been used effectively in treating chalazia, showing high success rates in previous studies.
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications.
Is 5-Fluorouracil generally safe for humans?
5-Fluorouracil (5-FU) is used in various treatments, including skin cancer and eye surgeries, and is generally considered safe when used as directed. Some studies show that it can cause mild skin irritation, but formulations like bioadhesive gels can reduce this risk. However, it can be toxic if ingested, especially in animals.12345
How does the drug 5-fluorouracil injection differ from other treatments for chalazion?
5-fluorouracil injection is unique because it is typically used to inhibit cell growth and scar formation, which is not a common approach for treating chalazion. This drug is often used in eye surgeries to prevent excessive tissue growth, suggesting a novel mechanism for addressing chalazion by potentially reducing inflammation and promoting healing.26789
What data supports the effectiveness of the drug 5-fluorouracil injection for treating chalazion?
Who Is on the Research Team?
Matthew M Zhang, MD
Principal Investigator
University of Washington Eye Institute
Are You a Good Fit for This Trial?
This trial is for individuals with one or more chalazia (styes) on a single eyelid. Participants must have had the chalazion for at least one month and should not have received any previous injections or surgical treatments for it.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive one of the four standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, or local injection of combination triamcinolone/5-FU
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- 5-fluorouracil Injection
- Triamcinolone Acetonide
5-fluorouracil Injection is already approved in European Union, United States, Canada for the following indications:
- Colorectal cancer
- Breast cancer
- Stomach cancer
- Pancreatic cancer
- Oesophageal cancer
- Cervical cancer
- Skin cancers
- Colorectal cancer
- Breast cancer
- Stomach cancer
- Pancreatic cancer
- Anal cancer
- Cervical cancer
- Head and neck cancers
- Skin cancers
- Colorectal cancer
- Breast cancer
- Stomach cancer
- Pancreatic cancer
- Oesophageal cancer
- Cervical cancer
- Skin cancers
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Washington
Lead Sponsor