Injection of triamcinolone/5FU mixture for Chalazion

University of Washington Eye Institute at Harborview, Seattle, WA
Chalazion5-fluorouracil Injection - Drug
All Sexes

Study Summary

This trial found that 5-fluorouracil injected into a chalazion was as effective as a steroid injection or surgery.

Treatment Effectiveness

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: 4 weeks

4 weeks
Meibomian Cyst

Trial Safety

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

4 Treatment Groups

Injection of triamcinolone/5FU mixture
1 of 4
Injection of Triamcinolone Acetonide
1 of 4
Incision and Curettage
1 of 4
Injection of 5-fluorouracil
1 of 4

Active Control

120 Total Participants · 4 Treatment Groups

Primary Treatment: Injection of triamcinolone/5FU mixture · No Placebo Group · Phase 3

Injection of triamcinolone/5FU mixtureActiveComparator Group · 2 Interventions: Triamcinolone Acetonide/5-fluorouracil mixture, Incision and Curettage · Intervention Types: Drug, Procedure
Injection of Triamcinolone AcetonideActiveComparator Group · 2 Interventions: Incision and Curettage, Triamcinolone Acetonide · Intervention Types: Procedure, Drug
Incision and Curettage
ActiveComparator Group · 1 Intervention: Incision and Curettage · Intervention Types: Procedure
Injection of 5-fluorouracilActiveComparator Group · 2 Interventions: 5-fluorouracil Injection, Incision and Curettage · Intervention Types: Drug, Procedure

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 4 weeks

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,635 Previous Clinical Trials
1,578,872 Total Patients Enrolled
Matthew M Zhang, MDPrincipal InvestigatorUniversity of Washington Eye Institute

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have one or more bumps on one eyelid called chalazia.

Frequently Asked Questions

What conditions does the Injection of triamcinolone/5FU mixture typically help improve?

"The most common use for this triamcinolone/5FU mixture is to treat ulcerative colitis, however it can also be injected to help with conditions such as hand and brain non-immunocompromised." - Anonymous Online Contributor

Unverified Answer

Are there other instances where this medication has been injected in patients?

"There are a total of 377 ongoing studies involving the injection of a triamcinolone/5FU mixture. 115 of those are clinical trials currently in progress, and the majority of those are located in Adelaide, South Australia. However, there are a total of 19148 locations running studies for this treatment." - Anonymous Online Contributor

Unverified Answer

Has the FDA cleared triamcinolone/5FU mixture for use in injections?

"Injection of triamcinolone/5FU mixture is considered safe based on our team's estimation. This is a Phase 3 trial, meaning that there is both evidence of efficacy and safety." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.