SGLT2 Inhibitors for Non-Alcoholic Fatty Liver Disease
(SLIDE Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as weight loss drugs, metformin, and vitamin E supplements, at least 6 months before joining. If you've recently started anti-hypertensive or lipid medications, you may also need to wait 3 months before enrolling.
What data supports the effectiveness of the drug Empagliflozin for treating Non-Alcoholic Fatty Liver Disease?
Research shows that Empagliflozin, a type of SGLT2 inhibitor, can reduce liver fat and improve liver health in people with Non-Alcoholic Fatty Liver Disease (NAFLD), both with and without type 2 diabetes. Studies found it significantly decreased liver enzyme levels and liver fat content, suggesting it could be a promising treatment option for NAFLD.12345
Is empagliflozin safe for humans?
How is the drug empagliflozin unique for treating non-alcoholic fatty liver disease?
Empagliflozin is unique because it is a type of drug called an SGLT2 inhibitor, which is primarily used to treat type 2 diabetes by helping the kidneys remove sugar from the body. Unlike other treatments for non-alcoholic fatty liver disease, empagliflozin also reduces liver fat and improves liver health, making it a novel option for patients with both diabetes and liver issues.23789
What is the purpose of this trial?
This trial tests empagliflozin, a medication that helps remove extra sugar through urine, in adolescents with obesity and a specific liver condition (NAFLD). The medication works by blocking a protein in the kidneys to help remove sugar from the body. Empagliflozin has been shown to reduce body weight, improve glucose tolerance, and decrease blood pressure in various studies.
Research Team
Justin Ryder, PhD
Principal Investigator
Ann & Robert H Lurie Children's Hospital of Chicago
Eligibility Criteria
Adolescents aged 12-19 with obesity and non-alcoholic fatty liver disease (NAFLD) can join. They must have high liver enzymes or a confirmed diagnosis of NAFLD/NASH, no significant alcohol intake, no metal implants incompatible with MRI, not pregnant nor planning to be, and without major organ dysfunction or other serious health issues.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive empagliflozin or placebo daily for 26 weeks, with lifestyle/behavioral counseling
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Empagliflozin
- Placebo Oral Tablet
Empagliflozin is already approved in European Union, United States, Canada, Japan for the following indications:
- Type 2 diabetes mellitus
- Heart failure with reduced ejection fraction
- Chronic kidney disease
- Type 2 diabetes mellitus
- Heart failure with reduced ejection fraction
- Chronic kidney disease
- Cardiovascular risk reduction
- Type 2 diabetes mellitus
- Heart failure with reduced ejection fraction
- Chronic kidney disease
- Type 2 diabetes mellitus
- Heart failure with reduced ejection fraction
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ann & Robert H Lurie Children's Hospital of Chicago
Lead Sponsor
University of Minnesota
Lead Sponsor