Eletriptan Hydrobromide

Migraine with Aura, Migraine without Aura

Treatment

4 Active Studies for Eletriptan Hydrobromide

What is Eletriptan Hydrobromide

Eletriptan

The Generic name of this drug

Treatment Summary

Eletriptan is a prescription medication used to stop migraine headaches. It was developed by Pfizer Inc and is part of a class of drugs called triptans.

Relpax

is the brand name

image of different drug pills on a surface

Eletriptan Hydrobromide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Relpax

Eletriptan

2002

26

Effectiveness

How Eletriptan Hydrobromide Affects Patients

Eletriptan works by activating certain receptors in the body. In animal studies, it was found to reduce blood flow in the carotid artery and reduce the size of the coronary artery, while also decreasing activity in the trigeminal nerve.

How Eletriptan Hydrobromide works in the body

Eletriptan binds to a few serotonin receptors in the brain which helps to reduce migraine pain. It works by constricting the blood vessels in the brain and inhibiting the release of pain-causing molecules. Eletriptan does not affect other receptors such as adrenergic, dopaminergic, muscarinic, or opioid receptors.

When to interrupt dosage

The prescribed measure of Eletriptan Hydrobromide is contingent upon the diagnosed condition. The amount of dosage alters, in accordance with the delivery technique (e.g. Tablet, film coated - Oral or Tablet, film coated) specified in the table beneath.

Condition

Dosage

Administration

Migraine without Aura

, 20.0 mg, 40.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Migraine with Aura

, 20.0 mg, 40.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

Eletriptan Hydrobromide Contraindications

Condition

Risk Level

Notes

intestinal ischemia

Do Not Combine

Migraine with Aura

Do Not Combine

Coronary Vasospasm

Do Not Combine

Pulse Frequency

Do Not Combine

Stroke

Do Not Combine

Pulse Frequency

Do Not Combine

arrhythmias associated with conduction disorders

Do Not Combine

Peripheral Vascular Disease

Do Not Combine

Pulse Frequency

Do Not Combine

Atrioventricular Block

Do Not Combine

Pulse Frequency

Do Not Combine

Transient Ischemic Attack

Do Not Combine

Pulse Frequency

Do Not Combine

Hypertensive disease

Do Not Combine

Coronary Artery Disease

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Hemiplegic migraine

Do Not Combine

There are 20 known major drug interactions with Eletriptan Hydrobromide.

Common Eletriptan Hydrobromide Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Eletriptan.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Eletriptan.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Eletriptan.

Azelastine

Major

Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Eletriptan.

Eletriptan Hydrobromide Toxicity & Overdose Risk

Taking too much of a 5-HT1B/1D agonist could lead to high blood pressure or more serious heart problems.

image of a doctor in a lab doing drug, clinical research

Eletriptan Hydrobromide Novel Uses: Which Conditions Have a Clinical Trial Featuring Eletriptan Hydrobromide?

Currently, 4 active clinical trials are investigating the potential of Eletriptan Hydrobromide to alleviate Migraine Without Aura.

Condition

Clinical Trials

Trial Phases

Migraine with Aura

0 Actively Recruiting

Migraine without Aura

4 Actively Recruiting

Not Applicable, Phase 4

Eletriptan Hydrobromide Reviews: What are patients saying about Eletriptan Hydrobromide?

5

Patient Review

7/27/2020

Eletriptan Hydrobromide for Migraine Headache

Relpax has been an absolute godsend. It's the only medication that has ever worked for my migraines, and it does so within 30 minutes. If you're considering trying a triptan, just be sure to take it as soon as you start feeling a migraine coming on.

5

Patient Review

5/9/2008

Eletriptan Hydrobromide for Migraine Headache

5

Patient Review

2/18/2009

Eletriptan Hydrobromide for Migraine Headache

if you take this medication as soon as you start feeling sick, it works really well and quickly. I didn't experience any negative side effects.

5

Patient Review

2/24/2010

Eletriptan Hydrobromide for Migraine Headache

This is the most effective triptan I've tried, by far. It works within two hours, and I only need to take it once. Of course, it's very expensive.

5

Patient Review

9/16/2008

Eletriptan Hydrobromide for Migraine Headache

If you take this drug as soon as you feel a migraine coming on, it's extremely effective. Just resting for 15-30 minutes is often all I need to make the headache go away entirely.

5

Patient Review

2/12/2010

Eletriptan Hydrobromide for Migraine Headache

This medication has been working well for me. I was experiencing dizziness and wasn't sure if it was the medication, but I think it might be a side effect. I've also felt very emotional at times while taking Relpax.

4.3

Patient Review

12/8/2009

Eletriptan Hydrobromide for Migraine Headache

I get really bad lockjaw from this medicine, to the point where it interferes with my ability to work. However, it's much more effective than any other treatment I've tried.

4.3

Patient Review

3/9/2009

Eletriptan Hydrobromide for Migraine Headache

Relpax has been great for me, significantly reducing the severity of my headaches. The only downside is how expensive they are.

4.3

Patient Review

4/17/2014

Eletriptan Hydrobromide for Migraine Headache

This is the only medication that has ever stopped my migraine. It 'cures' the migrane within an hour and continues to work for close to 24 hours. It is important to take it as soon as the headache starts for best results. I do have trouble getting the pill out of the package. I keep a pair of scissors next to the package for that reason. The medication makes me sleepy, but in a good way because it relaxes me so much.

4

Patient Review

12/4/2018

Eletriptan Hydrobromide for Migraine Headache

The medication works well. I get so frustrated trying to get the pill out of the package. I was taking Azor and that package is the same way - impossible to open without a knife for something similar to poke a hole in the back of the package. If they can't put it in a bottle then at least make it easier to poke the pill out!

3.7

Patient Review

2/10/2010

Eletriptan Hydrobromide for Migraine Headache

This medication was effective, but I didn't like the side effects. I felt dizzy and lightheaded for not just the day of treatment, but also the next day. It made it hard to get up and do my daily activities.

3.3

Patient Review

5/22/2014

Eletriptan Hydrobromide for Migraine Headache

I experienced some very unpleasant side effects from this medication, including lockjaw and dizziness.

2.3

Patient Review

5/22/2021

Eletriptan Hydrobromide for Migraine Headache

I have not found this medication to be helpful at all for my migraines. Very disappointing and now I'm considering Botox injections as a next step.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about eletriptan hydrobromide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of eletriptan?

"The following text is about the side effects of eletriptan. Eletriptan can commonly cause chest/jaw/neck tightness, pain, or pressure. These side effects are usually not serious. However, they can be like symptoms of a heart attack, which may include chest/jaw/left arm pain, shortness of breath, or unusual sweating."

Answered by AI

How strong is eletriptan?

"Eletriptan (Relpax) is available in two strengths which can be taken as a single dose: 20 mg and 40 mg. The recommended dose for eletriptan (Relpax) is 1 tablet consumed orally once for migraine pain. If the headache returns, the dose can be repeated 2 hours after the initial dose. Do not consume more than 80 mg in a day."

Answered by AI

What is eletriptan hydrobromide used for?

"Eletriptan is a drug used to treat acute migraine headaches in adults. It is not effective in preventing migraine headaches or cluster headaches. Eletriptan works by reducing the pain associated with migraine headaches by affecting the brain. It is classified as a triptan, a group of drugs used to treat migraines."

Answered by AI

How long does eletriptan take to work?

"Cluster headaches typically only last for 30 to 45 minutes, but in some cases they can last for a few hours. Relpax may take up to two hours to take full effect. However, by that time the cluster headache may already be gone. Relpax is not effective in preventing future cluster headaches."

Answered by AI

Clinical Trials for Eletriptan Hydrobromide

Image of University of California, Irvine Medical Center ENT Clinic (Pavilion 2) in Orange, United States.

Migraine Medications for Tinnitus

25 - 85
All Sexes
Orange, CA

Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. Despite too many research projects on finding the mechanism of tinnitus, its pathophysiology remains poorly understood. It is well understood that many factors, such as poor education, lower income, or occupational, and recreational activity associated with high noise exposure, influence the prevalence and risk of tinnitus. Although the economic and emotional impact of tinnitus is large, there is currently no FDA-approved medication to treat this condition. However, there are pharmacological options to address the stress, anxiety, and depression that are caused by tinnitus. In this project, the investigators intend to use medications for patients with acute tinnitus to decrease the impact of tinnitus in their daily lives and activities. There are some studies on medications treating tinnitus; however, there are few randomized clinical trials to prove the efficacy of the treatment. The frequency and loudness of tinnitus will be measured before and after the course. Functional MRI of the brain will be obtained to view any changes that may occur before and after the treatment.

Phase 4
Waitlist Available

University of California, Irvine Medical Center ENT Clinic (Pavilion 2)

Mehdi Abouzari, MD, PhD