Etidronate Disodium

Osteitis Deformans, Spinal Cord Injury, Heterotopic Ossification + 1 more
Treatment
7 FDA approvals
20 Active Studies for Etidronate Disodium

What is Etidronate Disodium

Etidronic acidThe Generic name of this drug
Treatment SummaryEtidronic acid is a medication used to regulate the calcification and decalcification of bones. It is a first generation bisphosphonate, similar to clodronic acid and tiludronic acid. Etidronic acid was approved by the FDA in 1977, but over the years it has been replaced by newer, more effective third-generation nitrogen-containing bisphosphonates such as zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.
Didronelis the brand name
Etidronate Disodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Didronel
Etidronic acid
1977
9

Approved as Treatment by the FDA

Etidronic acid, commonly known as Didronel, is approved by the FDA for 7 uses such as Paget's Disease of Bone and Spinal Cord Injuries (SCI) .
Paget's Disease of Bone
Spinal Cord Injuries (SCI)
Heterotopic Ossification (HO)
Total Hip Replacements
Heterotopic Ossification
Spinal Cord Injury
Osteitis Deformans

Effectiveness

How Etidronate Disodium Affects PatientsEtidronic acid is a drug that stops the body from reabsorbing bones. It is generally safe and produces long-lasting effects. However, patients should be warned about potential side effects in the upper digestive tract.
How Etidronate Disodium works in the bodyBisphosphonates work to stop bone from being broken down. When they enter the bone they attach to hydroxyapatite and are released when the acidity level changes. The bisphosphonates then enter the osteoclasts, which normally break down the bone. The bisphosphonates disrupt the action of osteoclasts by blocking the ability of the cells to create ring-shaped structures of F-actin. This prevents them from breaking down the bone and stops bone resorption. First generation bisphosphonates also prevent osteoclasts from using ATP, which further stops the process of bone res

When to interrupt dosage

The recommended amount of Etidronate Disodium is contingent upon the determined condition, such as Total Hip Replacements, Paget's Disease of Bone and Heterotopic Ossification. Dosage likewise relies upon the technique of delivery delineated in the table underneath.
Condition
Dosage
Administration
Spinal Cord Injury
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Heterotopic Ossification
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Total Hip Replacements
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Osteitis Deformans
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution

Warnings

Etidronate Disodium has five contraindications that preclude its utilization in combination with the conditions listed in the table below.Etidronate Disodium Contraindications
Condition
Risk Level
Notes
Esophageal Achalasia
Do Not Combine
delayed esophageal emptying
Do Not Combine
Esophageal Strictures
Do Not Combine
Esophagus
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Etidronic Acid may interact with Pulse Frequency
There are 5 known major drug interactions with Etidronate Disodium.
Common Etidronate Disodium Drug Interactions
Drug Name
Risk Level
Description
Incadronic acid
Minor
The risk or severity of adverse effects can be increased when Etidronic acid is combined with Incadronic acid.
Tiludronic acid
Minor
The risk or severity of adverse effects can be increased when Etidronic acid is combined with Tiludronic acid.
Deferasirox
Moderate
The risk or severity of gastrointestinal bleeding and gastrointestinal ulceration can be increased when Etidronic acid is combined with Deferasirox.
Parathyroid hormone
Moderate
The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Etidronic acid.
Technetium Tc-99m oxidronate
Moderate
The risk or severity of hypocalcemia can be increased when Etidronic acid is combined with Technetium Tc-99m oxidronate.
Etidronate Disodium Toxicity & Overdose RiskOverdosing on calcium carbonate may cause symptoms such as low calcium levels, vomiting, tingling sensations, and diarrhea. Treatment for overdose consists of managing any electrolyte imbalances and providing intravenous calcium gluconate to help relieve symptoms.

Etidronate Disodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Etidronate Disodium?

48 active clinical trials are presently being conducted to assess the usefulness of Etidronate Disodium in treating Heterotopic Ossification, Paget's Disease of Bone and Spinal Cord Injury.
Condition
Clinical Trials
Trial Phases
Osteitis Deformans
0 Actively Recruiting
Heterotopic Ossification
0 Actively Recruiting
Total Hip Replacements
0 Actively Recruiting
Spinal Cord Injury
67 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 1

Etidronate Disodium Reviews: What are patients saying about Etidronate Disodium?

3Patient Review
12/16/2010
Etidronate Disodium for Glucocorticoid-Induced Osteoporosis Prevention
I've been on this medication for over half a decade now and haven't seen any improvement in my bone scan.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about etidronate disodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a disadvantage of etidronate?

"Painful, itchy blisters on the skin that peel and eventually fall off. Joint and muscle pain that is severe and occasionally prevents movement. A burning, crawling, or prickling sensation under the skin. Difficulty swallowing."

Answered by AI

What are etidronate disodium tablets for?

"Etidronate is a medication used to treat Paget's disease, a condition which weakens and deforms bones. By slowing bone loss, etidronate helps make bones stronger and less likely to break. It also alleviates bone pain associated with Paget's disease."

Answered by AI

When should I take etidronate?

"You should take etidronate with a full glass of water on an empty stomach at least 2 hours before or after food."

Answered by AI

Is etidronate discontinued?

"os

This drug is no longer available in the United States. The typical dose was 7.5 mg/kg IV infusion given once every day for three days in a row. Etidronate was considered a drug for a rare condition by the FDA, but etidronate therapy has been replaced with more powerful bisphosphonates for this condition."

Answered by AI

Clinical Trials for Etidronate Disodium

Image of Shirley Ryan AbilityLab in Chicago, United States.

Paired Associative Stimulation + Locomotor Training for Spinal Cord Injury

18 - 75
All Sexes
Chicago, IL
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI. Although studies have shown that locomotor training improves locomotor function in people with chronic SCI, the benefits remain limited. Our overall hypothesis is that we can engage additional descending motor pathways, such as the reticulospinal tract (RST), to improve locomotor function in humans with chronic incomplete SCI. In this study we propose to test the effects of a novel intervention that uses repeated paired loud auditory and electrical stimulation of muscle afferents combined with locomotor training on walking speed and voluntary muscle strength.
Phase 1 & 2
Waitlist Available
Shirley Ryan AbilityLabDalia De Santis, PhD
Have you considered Etidronate Disodium clinical trials? We made a collection of clinical trials featuring Etidronate Disodium, we think they might fit your search criteria.Go to Trials
Image of Cognixion HQ in Santa Barbara, United States.

Cognixion + Apple Vision Pro for ALS

18+
All Sexes
Santa Barbara, CA
The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI) or spinal cord injury (SCI) that have assistive communication and computer control needs. Each subject will receive an integrated Cognixion + Apple Vision Pro device that includes an augmented reality brain computer interface and associated communication software. The study duration is 3-4 months for each participant. The key questions that will be addressed in this study are: 1. Identify the ability of individuals with target indications to use the integrated Cognixion-Apple Vision Pro system to communicate effectively. 2. Identify the ability of such individuals to learn to use BCI, ET-BCI and other modalities, and to measure their progress over time. 3. Identify the effectiveness of the different forms of input supported by the combined Cognixion-Apple Vision Pro system (BCI, eye-tracking) in allowing such individuals to communicate and have agency. 4. Identify how input such as BCI can be optimized to suit the needs of individuals (e.g., specific frequencies that work best for an individual, SNR with different frequencies, number of targets, length of recording for each frequency) and improve overall usability. 5. Identify the extent to which personalization through a large language model (LLM) affects communication. 6. Identify the appropriate capabilities to enable through an agentic communication interface. Key measures include: ITR - information transfer rate SUS - system usability scale
Waitlist Available
Has No Placebo
Cognixion HQChristopher J UllrichCognixion
Image of Medical University of South Carolina in Charleston, United States.

Motor Evoked Potential Conditioning for Spinal Cord Injury

18+
All Sexes
Charleston, SC
The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement problems after injuries. Spinal cord injury causes damage to the brain-to-muscle connection. However, when the injury is "incomplete", there is a possibility that some of the brain-to-muscle pathways are still connected and may be trained to improve movement function. For examining brain-to-muscle pathways, investigators use a transcranial magnetic stimulator. Investigators hope that the results of this research study will help us develop new treatments for people who have movement disabilities. This study will require about 42 visits over the first 14 weeks, and another 6 visits over an additional 3 months. Each visit will take about 1 ½ hours.
Recruiting
Has No Placebo
Medical University of South CarolinaAiko Thompson, PhD
Have you considered Etidronate Disodium clinical trials? We made a collection of clinical trials featuring Etidronate Disodium, we think they might fit your search criteria.Go to Trials
Image of Stollery Children's Hospital in Edmonton, Canada.

Surgical Treatment for Ankle Equinus

4 - 17
All Sexes
Edmonton, Canada
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk. If not treated, children with ankle equinus frequently experience reduced function and long-term foot problems, such as pain. Currently, treatment options include surgery or Botulinum toxin (BoNTA) injection into the large calf muscles that point the foot downwards, aiming to reduce their tightness. However, these treatments can be less effective over time, can create prolonged calf weakness, and may require long-term bracing. Another small muscle in the leg, the plantaris, is believed to have some contribution to equinus in many children. It is sometimes included in treatment plans for equinus but its contribution is poorly understood. It is unclear whether targeting the plantaris alone could lead to better treatment of ankle equinus. Understanding the effect of treatments targeting the plantaris could help clinicians improve the management of ankle equinus. In this study, the investigators will look at the impact of surgical treatment to the plantaris in ankle equinus. The investigators hypothesize that the plantaris is a significant contributor to equinus. In this study, data will be collected from children undergoing surgical correction of ankle equinus, including lengthening of the plantaris and lengthening of the larger muscles producing equinus (the gastrocsoleus mechanism). Children will be randomly assigned to have either their plantaris or the gastrocsoleus lengthening be done first during surgery. All children will have both structures lengthened during surgery, only the order will be varied and all surgical procedures for each patient will be completed in a single setting. In both groups, maximum passive ankle dorsiflexion (upwards bend of the ankle with the knee straight) will be measured before and after each structure is lengthened. The outcome is maximum passive ankle dorsiflexion (upwards bend of the ankle) with the knee straight. The investigators expect that maximum passive ankle dorsiflexion will increase after lengthening of the plantaris. Understanding the contribution of the plantaris muscle in ankle equinus could lead to significant improvements in the treatment of children with tight ankles.
Recruiting
Has No Placebo
Stollery Children's HospitalSukhdeep Dulai, MD, MHSc, FRCSC
Image of Kessler Foundation in West Orange, United States.

Epidural Stimulation for Spinal Cord Injury

18+
All Sexes
West Orange, NJ
The goal of this study is to understand long-term effects of spinal cord stimulation in individuals who have a spinal cord injury. The main aims are to: 1. provide support for those with epidural stimulators who choose to continue stimulating because they deemed them to improve their quality of life 2. provide additional sites for follow-up so that the financial burden can be minimized for the research participants to travel 3. collect long-term safety data; and 4. when feasible collect data to understand the sustainability of outcomes. Participants will: * receive stimulation programs and software for the activities and/or functions completed in the previous study and demonstrate to the research staff that I can conduct them without their help to use at home * continue using the stimulation programs at home as directed by the research staff * return to Kessler Foundation for a follow-up visit (approx. 2 hours) with assessments at 6 months, 1 year, and once a year after enrolled in the follow-up study last until either the device is turned off, removed or the device is commercially approved.
Waitlist Available
Has No Placebo
Kessler Foundation
Have you considered Etidronate Disodium clinical trials? We made a collection of clinical trials featuring Etidronate Disodium, we think they might fit your search criteria.Go to Trials
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