Etidronate Disodium

Osteitis Deformans, Spinal Cord Injury, Heterotopic Ossification + 1 more
Treatment
7 FDA approvals
20 Active Studies for Etidronate Disodium

What is Etidronate Disodium

Etidronic acidThe Generic name of this drug
Treatment SummaryEtidronic acid is a medication used to regulate the calcification and decalcification of bones. It is a first generation bisphosphonate, similar to clodronic acid and tiludronic acid. Etidronic acid was approved by the FDA in 1977, but over the years it has been replaced by newer, more effective third-generation nitrogen-containing bisphosphonates such as zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.
Didronelis the brand name
Etidronate Disodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Didronel
Etidronic acid
1977
9

Approved as Treatment by the FDA

Etidronic acid, commonly known as Didronel, is approved by the FDA for 7 uses such as Paget's Disease of Bone and Spinal Cord Injuries (SCI) .
Paget's Disease of Bone
Spinal Cord Injuries (SCI)
Heterotopic Ossification (HO)
Total Hip Replacements
Heterotopic Ossification
Spinal Cord Injury
Osteitis Deformans

Effectiveness

How Etidronate Disodium Affects PatientsEtidronic acid is a drug that stops the body from reabsorbing bones. It is generally safe and produces long-lasting effects. However, patients should be warned about potential side effects in the upper digestive tract.
How Etidronate Disodium works in the bodyBisphosphonates work to stop bone from being broken down. When they enter the bone they attach to hydroxyapatite and are released when the acidity level changes. The bisphosphonates then enter the osteoclasts, which normally break down the bone. The bisphosphonates disrupt the action of osteoclasts by blocking the ability of the cells to create ring-shaped structures of F-actin. This prevents them from breaking down the bone and stops bone resorption. First generation bisphosphonates also prevent osteoclasts from using ATP, which further stops the process of bone res

When to interrupt dosage

The recommended amount of Etidronate Disodium is contingent upon the determined condition, such as Total Hip Replacements, Paget's Disease of Bone and Heterotopic Ossification. Dosage likewise relies upon the technique of delivery delineated in the table underneath.
Condition
Dosage
Administration
Spinal Cord Injury
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Heterotopic Ossification
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Total Hip Replacements
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution
Osteitis Deformans
200.0 mg, , 400.0 mg, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Intravenous, Solution - Intravenous, Solution

Warnings

Etidronate Disodium has five contraindications that preclude its utilization in combination with the conditions listed in the table below.Etidronate Disodium Contraindications
Condition
Risk Level
Notes
Esophageal Achalasia
Do Not Combine
delayed esophageal emptying
Do Not Combine
Esophageal Strictures
Do Not Combine
Esophagus
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Etidronic Acid may interact with Pulse Frequency
There are 5 known major drug interactions with Etidronate Disodium.
Common Etidronate Disodium Drug Interactions
Drug Name
Risk Level
Description
Incadronic acid
Minor
The risk or severity of adverse effects can be increased when Etidronic acid is combined with Incadronic acid.
Tiludronic acid
Minor
The risk or severity of adverse effects can be increased when Etidronic acid is combined with Tiludronic acid.
Deferasirox
Moderate
The risk or severity of gastrointestinal bleeding and gastrointestinal ulceration can be increased when Etidronic acid is combined with Deferasirox.
Parathyroid hormone
Moderate
The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Etidronic acid.
Technetium Tc-99m oxidronate
Moderate
The risk or severity of hypocalcemia can be increased when Etidronic acid is combined with Technetium Tc-99m oxidronate.
Etidronate Disodium Toxicity & Overdose RiskOverdosing on calcium carbonate may cause symptoms such as low calcium levels, vomiting, tingling sensations, and diarrhea. Treatment for overdose consists of managing any electrolyte imbalances and providing intravenous calcium gluconate to help relieve symptoms.

Etidronate Disodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Etidronate Disodium?

48 active clinical trials are presently being conducted to assess the usefulness of Etidronate Disodium in treating Heterotopic Ossification, Paget's Disease of Bone and Spinal Cord Injury.
Condition
Clinical Trials
Trial Phases
Osteitis Deformans
0 Actively Recruiting
Heterotopic Ossification
0 Actively Recruiting
Total Hip Replacements
0 Actively Recruiting
Spinal Cord Injury
53 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 1

Etidronate Disodium Reviews: What are patients saying about Etidronate Disodium?

3Patient Review
12/16/2010
Etidronate Disodium for Glucocorticoid-Induced Osteoporosis Prevention
I've been on this medication for over half a decade now and haven't seen any improvement in my bone scan.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about etidronate disodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a disadvantage of etidronate?

"Painful, itchy blisters on the skin that peel and eventually fall off. Joint and muscle pain that is severe and occasionally prevents movement. A burning, crawling, or prickling sensation under the skin. Difficulty swallowing."

Answered by AI

What are etidronate disodium tablets for?

"Etidronate is a medication used to treat Paget's disease, a condition which weakens and deforms bones. By slowing bone loss, etidronate helps make bones stronger and less likely to break. It also alleviates bone pain associated with Paget's disease."

Answered by AI

When should I take etidronate?

"You should take etidronate with a full glass of water on an empty stomach at least 2 hours before or after food."

Answered by AI

Is etidronate discontinued?

"os

This drug is no longer available in the United States. The typical dose was 7.5 mg/kg IV infusion given once every day for three days in a row. Etidronate was considered a drug for a rare condition by the FDA, but etidronate therapy has been replaced with more powerful bisphosphonates for this condition."

Answered by AI

Clinical Trials for Etidronate Disodium

Have you considered Etidronate Disodium clinical trials? We made a collection of clinical trials featuring Etidronate Disodium, we think they might fit your search criteria.
Have you considered Etidronate Disodium clinical trials? We made a collection of clinical trials featuring Etidronate Disodium, we think they might fit your search criteria.
Have you considered Etidronate Disodium clinical trials? We made a collection of clinical trials featuring Etidronate Disodium, we think they might fit your search criteria.
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