Imdur

Coronary Disease, Chest Pain

Treatment

3 Active Studies for Imdur

Treatment for

Coronary Disease

What is Imdur

Isosorbide mononitrateThe Generic name of this drug

Treatment SummaryIsosorbide mononitrate is a medication used to treat chest pain (angina pectoris) caused by coronary artery disease. It works by relaxing the blood vessels to reduce the workload on the heart. It was approved by the FDA in 1991 and is available in oral tablets and extended-release forms under the brand name ISMO, Monoket, and Imdur. While it takes longer to start working than nitroglycerin, it lasts longer and is effective in preventing angina attacks.

Monoketis the brand name

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Imdur Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Monoket

Isosorbide mononitrate

1993

188

Effectiveness

How Imdur Affects PatientsIsosorbide mononitrate is a drug used to prevent and treat chest pain (angina). It works by releasing a compound called nitric oxide when it is metabolized. Nitric oxide causes veins and arteries to relax, which lowers the pressure in the veins returning to the heart, decreases the pressure in the aorta, and relaxes the blood vessels in the heart. This increases blood flow to the heart and reduces how much oxygen it needs. Isosorbide mononitrate takes effect within an hour and its effects can last up to 12 hours. It can also affect other types of smooth muscles like those

How Imdur works in the bodyIsosorbide mononitrate helps the body produce nitric oxide, which relaxes the walls of blood vessels. This is done by increasing the levels of a molecule called cyclic GMP, which then triggers a chain reaction inside the cell that leads to reduced calcium levels. Lower calcium levels cause the muscles around the blood vessels to relax, widening the vessels and allowing more blood to flow.

When to interrupt dosage

The dose of Imdur is contingent upon the diagnosed condition. The quantity of dosage fluctuates depending on the mode of delivery (e.g. Tablet or Tablet, extended release) as depicted in the table below.

Condition

Dosage

Administration

Coronary Disease

120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg

, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral

Chest Pain

120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg

Warnings

Imdur Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Isosorbide Mononitrate may interact with Pulse Frequency

There are 20 known major drug interactions with Imdur.

Common Imdur Drug Interactions

Drug Name

Risk Level

Description

Riociguat

Major

Isosorbide mononitrate may increase the hypotensive activities of Riociguat.

Sildenafil

Major

The risk or severity of hypotension can be increased when Isosorbide mononitrate is combined with Sildenafil.

Abacavir

Minor

Isosorbide mononitrate may decrease the excretion rate of Abacavir which could result in a higher serum level.

Acebutolol

Minor

The risk or severity of adverse effects can be increased when Isosorbide mononitrate is combined with Acebutolol.

Aclidinium

Minor

Isosorbide mononitrate may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Imdur Toxicity & Overdose RiskThe lowest toxic dose of isosorbide mononitrate in rats has been shown to be 2010mg/kg and 1771mg/kg in mice. Overdosing on this drug can cause a range of symptoms such as dilation of blood vessels, low blood pressure, headache, confusion, dizziness, palpitations, visual disturbances, nausea and vomiting, shortness of breath, fever, chills, heart blocks and bradycardia, paralysis, coma, seizures and even death. Treatment for overdose includes increasing the patient’s central fluid volume by elevating their legs and administering intravenous normal saline solution.

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Imdur Novel Uses: Which Conditions Have a Clinical Trial Featuring Imdur?

11 active studies are currently in progress to examine the potential of Imdur to alleviate Chest Pain.

Condition

Clinical Trials

Trial Phases

Coronary Disease

1 Actively Recruiting

Not Applicable

Chest Pain

2 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Imdur Reviews: What are patients saying about Imdur?

5Patient Review

5/12/2015

Imdur for Chronic Stable Angina

It took a little bit of getting used to, but this medication has been great at controlling my chest tightness. The only downside is that it made me feel foggy and gave me headaches for the first few days, but that has since gone away.

5Patient Review

10/30/2018

Imdur for Chronic Heart Failure

No more chest pain.

4.7Patient Review

6/18/2014

Imdur for Angina Pectoris Prevention

I'm on Imdur 120 mgl 4 times a day for chest pain per my angina doctor's orders. So far I haven't noticed any change in my pain. Has anyone else who is taking this drug had similar experiences?

4.3Patient Review

10/8/2013

Imdur for Angina Pectoris Prevention

4Patient Review

6/25/2016

Imdur for Angina Pectoris Prevention

I initially experienced headaches when starting this medication, but they eventually subsided. I've been taking it for approximately five months now with few problems. The only issues I have are congestion in my ears and a weepy left eye; perhaps if I took the medication at bedtime instead of in the morning, that would alleviate those symptoms.

View All Reviews

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Patient Q&A Section about imdur

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Imdur drug used for?

"This medication is used to prevent chest pain in patients with coronary artery disease. It is in a class of drugs called nitrates and works by relaxing and widening blood vessels so blood can flow more easily to the heart."

Answered by AI

Is Imdur a nitroglycerin?

"Imdur and Nitrolingual are both vasodilators used to prevent angina pectoris, and they have similar side effects like dizziness."

Answered by AI

What is the best time to take Imdur?

"The recommended dosage for IMDUR tablets is to take them in the morning upon waking up. The extended release tablets should not be chewed or crushed, and should be swallowed with half a glass of water."

Answered by AI

Does Imdur lower your blood pressure?

"If you take these medicines together, your blood pressure can drop suddenly and seriously. If you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, feeling unwell), get emergency medical attention. Do not stop taking this medicine suddenly."

Answered by AI