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What is Imdur
Isosorbide mononitrateThe Generic name of this drug
Treatment SummaryIsosorbide mononitrate is a medication used to treat chest pain (angina pectoris) caused by coronary artery disease. It works by relaxing the blood vessels to reduce the workload on the heart. It was approved by the FDA in 1991 and is available in oral tablets and extended-release forms under the brand name ISMO, Monoket, and Imdur. While it takes longer to start working than nitroglycerin, it lasts longer and is effective in preventing angina attacks.
Monoketis the brand name
Imdur Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Monoket
Isosorbide mononitrate
1993
188
Effectiveness
How Imdur Affects PatientsIsosorbide mononitrate is a drug used to prevent and treat chest pain (angina). It works by releasing a compound called nitric oxide when it is metabolized. Nitric oxide causes veins and arteries to relax, which lowers the pressure in the veins returning to the heart, decreases the pressure in the aorta, and relaxes the blood vessels in the heart. This increases blood flow to the heart and reduces how much oxygen it needs. Isosorbide mononitrate takes effect within an hour and its effects can last up to 12 hours. It can also affect other types of smooth muscles like those
How Imdur works in the bodyIsosorbide mononitrate helps the body produce nitric oxide, which relaxes the walls of blood vessels. This is done by increasing the levels of a molecule called cyclic GMP, which then triggers a chain reaction inside the cell that leads to reduced calcium levels. Lower calcium levels cause the muscles around the blood vessels to relax, widening the vessels and allowing more blood to flow.
When to interrupt dosage
The dose of Imdur is contingent upon the diagnosed condition. The quantity of dosage fluctuates depending on the mode of delivery (e.g. Tablet or Tablet, extended release) as depicted in the table below.Condition
Dosage
Administration
Chest Pain
120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg
, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral
Coronary Artery Disease (CAD)
120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg
, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Imdur ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isosorbide Mononitrate may interact with Pulse Frequency
Common Imdur Drug Interactions
Drug Name
Risk Level
Description
Riociguat
Major
Isosorbide mononitrate may increase the hypotensive activities of Riociguat.
Sildenafil
Major
The risk or severity of hypotension can be increased when Isosorbide mononitrate is combined with Sildenafil.
Abacavir
Minor
Isosorbide mononitrate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Isosorbide mononitrate is combined with Acebutolol.
Aclidinium
Minor
Isosorbide mononitrate may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Imdur Toxicity & Overdose RiskThe lowest toxic dose of isosorbide mononitrate in rats has been shown to be 2010mg/kg and 1771mg/kg in mice. Overdosing on this drug can cause a range of symptoms such as dilation of blood vessels, low blood pressure, headache, confusion, dizziness, palpitations, visual disturbances, nausea and vomiting, shortness of breath, fever, chills, heart blocks and bradycardia, paralysis, coma, seizures and even death. Treatment for overdose includes increasing the patient’s central fluid volume by elevating their legs and administering intravenous normal saline solution.
Imdur Novel Uses: Which Conditions Have a Clinical Trial Featuring Imdur?
11 active studies are currently in progress to examine the potential of Imdur to alleviate Chest Pain.Condition
Clinical Trials
Trial Phases
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Imdur Reviews: What are patients saying about Imdur?
5Patient Review
5/12/2015 It took a little bit of getting used to, but this medication has been great at controlling my chest tightness. The only downside is that it made me feel foggy and gave me headaches for the first few days, but that has since gone away.
5Patient Review
10/30/2018 No more chest pain.
4.7Patient Review
6/18/2014 I'm on Imdur 120 mgl 4 times a day for chest pain per my angina doctor's orders. So far I haven't noticed any change in my pain. Has anyone else who is taking this drug had similar experiences?
4.3Patient Review
10/8/20134Patient Review
6/25/2016 I initially experienced headaches when starting this medication, but they eventually subsided. I've been taking it for approximately five months now with few problems. The only issues I have are congestion in my ears and a weepy left eye; perhaps if I took the medication at bedtime instead of in the morning, that would alleviate those symptoms.
4Patient Review
7/20/2014 I've been taking Imdur for a few years now and it's done wonders for my blood pressure. Recently, my doctor said I could cut back to half a tablet, and so far that seems to be working just fine.
3.7Patient Review
12/21/2014 I got bad headaches from this, but it did relieve my chest pain.
3.7Patient Review
9/10/20133Patient Review
7/22/2020 I felt really exhausted after taking this medication, to the point where it was difficult to fall asleep. On the plus side, my breathing did feel a bit better.
3Patient Review
2/9/2014 I'm experiencing fatigue and pain in my muscles, especially my calves and shoulders.
2Patient Review
4/21/2014 This does seem to help with my breathlessness, but it's not a cure-all.
1.7Patient Review
2/12/2014 The pain and pressure I felt in my head while taking this medication for my blocked coronary artery was unbearable. I thought I was going to die.
1Patient Review
9/27/2017 I took this yesterday and experienced pain in my arms from wrist to elbow by 5pm. The pain is still present as of 4:30am. I'll be contacting my doctor tomorrow morning. I also had mild dizziness and headache which have since subsided.
1Patient Review
10/28/2015 The side effects of this medication were so bad that I had to stay in the hospital for an extra two days. I would rather deal with the angina than take this medicine again.
1Patient Review
1/24/2018 I gave this medication a try but unfortunately it gave me an awful headache that quickly developed into a migraine. I also felt nauseous. This happened both days I tried taking the pill, so I stopped and got rid of the rest.
1Patient Review
9/27/2015 Taking this medication gave me an incredibly painful headache, made me feel nauseous and dizzy. I tried it again the next day and felt even worse; including upset stomach. It's been a week and I'm still experiencing symptoms.
Patient Q&A Section about imdur
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Imdur drug used for?
"This medication is used to prevent chest pain in patients with coronary artery disease. It is in a class of drugs called nitrates and works by relaxing and widening blood vessels so blood can flow more easily to the heart."
Answered by AI
Is Imdur a nitroglycerin?
"Imdur and Nitrolingual are both vasodilators used to prevent angina pectoris, and they have similar side effects like dizziness."
Answered by AI
What is the best time to take Imdur?
"The recommended dosage for IMDUR tablets is to take them in the morning upon waking up. The extended release tablets should not be chewed or crushed, and should be swallowed with half a glass of water."
Answered by AI
Does Imdur lower your blood pressure?
"If you take these medicines together, your blood pressure can drop suddenly and seriously. If you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, feeling unwell), get emergency medical attention. Do not stop taking this medicine suddenly."
Answered by AI