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Blood Flow Improvement Drugs + Supplements for Heart Failure (MPMA Trial)
MPMA Trial Summary
This trial will test whether drugs that improve blood flow, with or without supplements that may improve mitochondrial function, can improve exercise endurance and skeletal muscle function in people with HFpEF.
MPMA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowMPMA Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.MPMA Trial Design
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- Your methemoglobin level is higher than 5%.You have signs of high pressure in your blood vessels.I have severe lung disease or need extra oxygen.I am under 18 years old.I have significant heart valve issues.I have had a heart attack or heart procedure in the last 2 months.Your blood pressure drops by more than 20 points when you stand up.Your heart has certain measurements and pressures that show it may not be working properly, or you've had a previous episode of acute heart failure requiring intravenous diuretics.My heart's right side is not pumping well.My current medication has been the same for at least 1 month.You cannot have an MRI for medical reasons.Your hemoglobin level is lower than 10 grams per deciliter.My doctor does not consider my heart sac condition significant.I have chest pain due to a heart condition, as diagnosed by my doctor.Your blood pressure is very high (above 180) or very low (below 100) when you are sitting and resting.My heart pumps blood effectively.I am taking medication for heart or erection problems that cannot be stopped.Your blood potassium levels are higher than 5.0 mEq/L.I have high blood pressure in the lungs' arteries.My heart often beats faster than 100 beats per minute.I have moderate heart condition symptoms.I have a diagnosed heart muscle condition.I have heart issues found on a stress test that haven't been fixed or shown to be minor.Your heart's pumping ability was found to be less than 45% on a previous heart ultrasound or MRI.My liver is not working well (high enzyme levels or low albumin).My kidney function is severely reduced.You are not able or willing to do physical activity.
- Group 1: Potassium Nitrate
- Group 2: Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside
- Group 3: Potassium Chloride
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the Food and Drug Administration granted authorization for Potassium Nitrate?
"Potassium Nitrate has been tested and garnered a score of 2 on the safety scale; while there is some data supporting its security, it has yet to be proven effective in clinical trials."
What is the maximum number of participants included in this clinical investigation?
"Affirmative. The information hosted on clinicaltrials.gov reveals that this investigation is still actively recruiting, which began October 11th 2021 and was most recently modified April 27th 2022. At the moment, 53 participants are necessary for 1 centre involved in the trial."
Does this trial restrict participants to those over 80 years of age?
"The age limits for this medical study are 18 and above, with an upper limit of 85 years old."
Could I potentially be enrolled in this research program?
"A total of 53 individuals aged 18-85 suffering from heart failure with preserved ejection fraction (hfpef) may join this trial. Beyond that, they must have taken a stable medical therapy for at least one month and display NYHA Class II-III symptoms."
In what medical contexts is Potassium Nitrate commonly administered?
"Potassium Nitrate is a helpful tool in managing congestive heart failure (CHF), increasing sensitivity, looking after teeth, and aiding with lower extremity issues."
Could you provide information on preceding research involving Potassium Nitrate?
"Currently, 18 clinical research trials are underway on the efficacy of Potassium Nitrate. Of those active studies, 2 have advanced to Phase 3. Philadelphia serves as a major hub for these investigations with 22 locations conducting experiments into this medication's effects."
Is enrollment still available for this experiment?
"Indeed, the data hosted on clinicaltrials.gov indicates that this medical study is actively recruiting patients. Initially posted on October 11th 2021, it has been recently updated as of April 27th 2022 and requires 53 participants from one site."
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