High Flow Nasal Cannula for Pediatric Airway Procedures

Overseen By Candace Hernandez

Age: < 18

Sex: Any

Trial Phase: Academic

Sponsor: The University of Texas Health Science Center, Houston

Disqualifiers: Tracheostomy, Cyanotic heart disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 1 hour

80 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment High Flow Nasal Cannula for Pediatric Airway Procedures?

Research shows that high-flow nasal cannula (HFNC) is increasingly used in pediatric care, particularly for managing respiratory distress, and has been approved for use in various clinical settings. While specific data on its use for airway procedures is limited, its effectiveness in similar respiratory conditions suggests potential benefits. ^{1 2 3 4 5}

Is high flow nasal cannula safe for children?

High flow nasal cannula (HFNC) is increasingly used in pediatric care, especially for children with breathing difficulties, and is generally considered safe. However, there are some cases where it may not work as expected, and more research is needed to fully understand its safety outside of intensive care settings. ^{1 4 5 6 7}

How does the high flow nasal cannula treatment differ from other treatments for pediatric airway procedures?

The high flow nasal cannula (HFNC) is unique because it provides a non-invasive way to deliver oxygen at higher flow rates than standard oxygen therapy, which can help improve breathing in children with respiratory distress. Unlike other treatments, it is less invasive than mechanical ventilation and can be used outside of intensive care settings, making it more accessible for pediatric patients. ^{1 2 5 8 9}

What is the purpose of this trial?

The purpose of this study is to investigate which flow rate (higher versus lower) is most effective at increasing apneic time and preventing greater than 5% drop in desaturation, as well as assessing transcutaneous carbon dioxide (CO2) levels during airway procedures in children

Research Team

Zhen Huang, MD

Principal Investigator

The University of Texas Health Science Center, Houston

Eligibility Criteria

This trial is for children with asthma who are undergoing airway procedures. The study aims to find the best flow rate of oxygen to prevent significant drops in oxygen levels and manage CO2 during the procedure.

Inclusion Criteria

I am scheduled for throat and lung exams at CMHH.

I weigh at least 5 kilograms and use a specific flow rate for my treatment.

Exclusion Criteria

I have undergone procedures using lasers or cautery.

I have a heart condition that hasn't been fixed and causes low oxygen levels.

Emergency type cases

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo airway procedures with either high or low flow nasal cannula oxygenation to assess effectiveness in increasing apneic time and preventing desaturation

1 hour

Follow-up

Participants are monitored for safety and effectiveness after the procedure

4 weeks

Treatment Details

Interventions

• High Flow Nasal Cannula
• Low Flow Oxygenation

Trial Overview The trial is testing two different rates of nasal cannula oxygen flow: high and low. It will measure how well each helps maintain oxygen saturation above a certain level and control CO2 during pediatric airway procedures.

Participant Groups

Group I: Low Flow Experimental Treatment 1 Intervention

Group II: High flow Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

The University of Texas Health Science Center, Houston

Lead Sponsor

Trials

974

Recruited

361,000+

References

1. Australia pubmed.ncbi.nlm.nih.gov

A case series of paediatric high flow nasal cannula therapy. [2013]

2. Germany pubmed.ncbi.nlm.nih.gov

High-flow nasal cannula use in pediatric patients for other indications than acute bronchiolitis-a scoping review of randomized controlled trials. [2023]

3. United States pubmed.ncbi.nlm.nih.gov

The Clinical Impact of Heated Humidified High-Flow Nasal Cannula on Pediatric Respiratory Distress. [2022]

4. United States pubmed.ncbi.nlm.nih.gov

High flow nasal cannula use outside of the ICU; factors associated with failure. [2018]

5. United States pubmed.ncbi.nlm.nih.gov

Cardiopulmonary outcomes following high flow nasal cannula in pediatric population: A systematic review. [2023]

6. Switzerland pubmed.ncbi.nlm.nih.gov

Analysis of risk factors for the failure of respiratory support with high-flow nasal cannula oxygen therapy in children with acute respiratory dysfunction: A case-control study. [2022]

7. United States pubmed.ncbi.nlm.nih.gov

When to Transfer: Predictors of Pediatric High Flow Nasal Cannula Failure at a Community Hospital. [2023]

8. United States pubmed.ncbi.nlm.nih.gov

High-Flow Nasal Cannula Use Outside of the ICU Setting. [2020]

9. England pubmed.ncbi.nlm.nih.gov

Budget impact analysis of high-flow nasal cannula for infant bronchiolitis: the Colombian National Health System perspective. [2021]