Grafting Materials for Misaligned Teeth
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how different grafting materials affect bone and gum tissues in individuals with misaligned teeth. Researchers test two types of materials: one uses human donor tissue (allograft), and the other uses animal tissue (xenograft), both covered by a collagen membrane. The trial compares these materials to regular braces treatment. It seeks participants with slightly crowded bottom front teeth, no history of gum disease, and no need for tooth extraction in their treatment plan. As an unphased trial, it offers participants the chance to contribute to innovative dental research that could enhance future orthodontic treatments.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Studies have shown that using bone grafts with a collagen membrane is generally safe and well-tolerated. An allograft uses donor tissue that has been carefully processed to ensure safety. Research indicates that allografts usually support new bone growth effectively.
For xenografts, which use tissue from another species, safety remains a priority. These materials have been successfully used in dental procedures and are often secured with stitches to reduce complications.
Both methods have been used in dental treatments to improve jawbone health and align teeth without causing major issues. While every procedure carries some risk, past experiences generally consider these grafts safe.1234Why are researchers excited about this trial's treatments?
Researchers are excited about using allografts and xenografts with collagen membranes for treating misaligned teeth because these materials offer a new way to support bone growth and tissue regeneration. Unlike traditional braces or aligners that merely adjust the position of teeth, these grafting materials actively enhance the surrounding bone and gum tissue, potentially leading to more stable and long-lasting results. The addition of collagen membranes in these grafts helps to integrate the material with the body's natural tissues more effectively, which might reduce recovery time and improve overall treatment outcomes.
What evidence suggests that this trial's treatments could be effective for misaligned teeth?
Research has shown that certain materials can support orthodontic treatments for crooked teeth. In this trial, participants in Group A will receive an allograft with a collagen membrane. Studies have found that this can improve bone and tissue support, which is important for aligning teeth and keeping them stable after straightening.
Participants in Group B will receive a xenograft with a collagen membrane, using bone material from a different species. This method has been shown to promote bone growth and healing, crucial for maintaining teeth in their new position after orthodontic work. Both treatments in this trial aim to provide stronger support for teeth alignment, potentially leading to more effective and lasting results.1567Who Is on the Research Team?
Sahar Dowlatshahi, DDS, MMSc
Principal Investigator
The University of Texas Health Science Center, Houston
Are You a Good Fit for This Trial?
This trial is for individuals with misaligned teeth or malocclusion. Participants should be suitable candidates for orthodontic therapy and willing to undergo surgical procedures as part of their treatment.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive surgically facilitated orthodontics therapy with different grafting materials
Follow-up
Participants are monitored for radiographic changes and gingival tissue changes
What Are the Treatments Tested in This Trial?
Interventions
- Allograft with Collagen Membrane
- Xenograft with Collagen Membrane
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center, Houston
Lead Sponsor
American Academy of Periodontology Foundation
Collaborator