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Penicillin Antibiotic

Amoxicillin for Pneumonia

Phase 2 & 3
Led By Jocelyn Gravel, MD
Research Sponsored by St. Justine's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presence of respiratory symptoms (cough and/or dyspnea)
Presence of signs of pneumonia (tachypnea, abnormal breath sounds, crackles)
Screening 3 weeks
Treatment Varies
Follow Up 1 month
Awards & highlights

Study Summary

This trial will compare a twice-daily to a thrice-daily antibiotic regimen for the treatment of non-severe community acquired pneumonia in children.

Who is the study for?
This trial is for children aged 3 months to 18 years with non-severe community acquired pneumonia, showing symptoms like cough, fever, and abnormal breath sounds. They must have signs of pneumonia on a chest X-ray. Kids with severe allergic reactions to amoxicillin, chronic illnesses, or recent hospital stays are excluded.Check my eligibility
What is being tested?
The study tests if taking the antibiotic Amoxicillin twice daily is just as effective as three times daily for treating non-severe pneumonia in kids who visit the emergency department.See study design
What are the potential side effects?
Amoxicillin may cause side effects such as allergic reactions (rash), gastrointestinal issues (nausea, vomiting), and rarely more serious conditions like Stevens-Johnson syndrome.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have symptoms like coughing or difficulty breathing.
I am showing signs of pneumonia, like rapid breathing and unusual lung sounds.
I am between 3 months and 18 years old with a diagnosis of non-severe pneumonia.
I have a fever.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinical failure within 10 days of enrolment
Secondary outcome measures
Adverse events
Clinical recurrence
Emergency department revisit within 72 hours
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Twice a day regimenExperimental Treatment1 Intervention
Patients will received a prescription of amoxicillin (90mg/kg/day) divided in two doses daily.
Group II: Thrice a day regimenActive Control1 Intervention
Patients will received a prescription of amoxicillin (90mg/kg/day) divided in three doses daily.
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 4

Find a Location

Who is running the clinical trial?

St. Justine's HospitalLead Sponsor
196 Previous Clinical Trials
77,659 Total Patients Enrolled
Jocelyn Gravel, MDPrincipal InvestigatorSainte-Justine Hospital
5 Previous Clinical Trials
1,587 Total Patients Enrolled

Media Library

Amoxicillin (Penicillin Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT03031210 — Phase 2 & 3
Community-acquired Pneumonia Research Study Groups: Thrice a day regimen, Twice a day regimen
Community-acquired Pneumonia Clinical Trial 2023: Amoxicillin Highlights & Side Effects. Trial Name: NCT03031210 — Phase 2 & 3
Amoxicillin (Penicillin Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03031210 — Phase 2 & 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some common diseases that Amoxicillin is known to cure?

"Amoxicillin is primarily used to treat helicobacter pylori infection, though it can also be taken for other bacterial infections, community acquired pneumonia (cap), and acute otitis media (aom)."

Answered by AI

How many volunteers are being enrolled in this experiment?

"That is correct. The information available on clinicaltrials.gov leads us to believe that this study is currently looking for participants. This trial was first posted on 6/11/2017, and the most recent update was 5/3/2022. They are hoping to enroll 1370 patients from 1 site."

Answered by AI

Are we able to enroll more individuals in this research project?

"As of right now, this study requires new participants. The original posting was on June 11th, 2017, with the most recent update being May 3rd, 2022."

Answered by AI

Are people over the age of 50 elligible for this study?

"According to the eligibility requirements listed, patients aged 3 months to 18 years old may qualify for this trial. There are 45 studies that focus on pediatrics and 196 studies targeting an elderly population."

Answered by AI
~17 spots leftby Jun 2024