CLINICAL TRIAL

Fractionated Laser Resurfacing for Keratoma

EnrollingByInvitation · 18+ · All Sexes · Dayton, OH

This study is evaluating whether a treatment for actinic keratosis can reduce the risk of future skin cancers.

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About the trial for Keratoma

Eligible Conditions
Aging · Actinic Keratosis (AK) · Cancer, Cancer Nonmelanoma Skin · Keratosis, Actinic · Skin Neoplasms · Keratosis

Treatment Groups

This trial involves 2 different treatments. Fractionated Laser Resurfacing is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Fractionated Laser Resurfacing
DEVICE
Experimental Group 2
Fractionated Laser Resurfacing
DEVICE

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fractionated Laser Resurfacing
2007
N/A
~20

Eligibility

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
To possess both right and left forearms suggests that you are ambidextrous, or that you are able to use both of your arms equally well show original
At least sixty years of age, or older. show original
The ability to comprehend procedures and risks versus benefits is an important skill for making informed decisions show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: up to 5 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: up to 5 years.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Fractionated Laser Resurfacing will improve 2 primary outcomes in patients with Keratoma. Measurement will happen over the course of up to 5 years.

Change From Baseline in the Number of Actinic Keratosis due to FLR treatment.
UP TO 5 YEARS
Investigator will assess the number of actinic keratosis on both forearms.
Change From Baseline in the Number Non-Melanoma Skin Cancers due to FLR treatment.
UP TO 5 YEARS
Investigator will assess the number of actinic keratosis on both forearms.

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for keratoma?

In some lesions, surgical excision is the most common treatment since the cancer is less advanced; in other lesions, no definitive treatment has been established.

Anonymous Patient Answer

What is keratoma?

Keratoma is an uncommon disorder of the skin of children and young adults that presents as a slow enlarging, reddish-brown nodule that does not have an apparent source. These lesions are benign as is the case in most other keratomas. Unlike most other lesions, keratomas may occur at any age and on any body surface.

Anonymous Patient Answer

What are the signs of keratoma?

Keratoma may be present in the eyelids of one or both sexes. It is characterized by the presence of fine skin tags/hair, and associated with loss of lacrimal function. The ocular signs are limited to the cornea or eyelid (i.e., edema or dry eye, corneal opacitas, ulcers, keratitis, lids with adherent eyelashes, and keratoderma).

Anonymous Patient Answer

What causes keratoma?

Keratoma is often preceded by an act of trauma and most commonly occurs on the face and neck; however, keratomas occur on all body parts, including the oral mucosa. The patient's lifestyle and the environment in which the lesion appeared may influence the development and natural history of the lesion.

Anonymous Patient Answer

Can keratoma be cured?

At the time of the study, no keratoma can be cured, though some tumors can be stopped growing and can be treated with a local treatment method. Results from a recent paper, the surgeons have not succeeded in achieving complete healing.

Anonymous Patient Answer

How many people get keratoma a year in the United States?

Results from a recent clinical trial did not quantify the incidence of keratinizing squamous cell carcinoma of head and neck among the population in the United States. Additional, accurate, research is needed to determine if the incidence of keratinizing squamous cell carcinoma of head and neck is increasing in populations in the United States.

Anonymous Patient Answer

What is the latest research for keratoma?

The incidence and prevalence of keratoma have dropped markedly in the United States; the use of artificial tears, moisturizing eye cream, and sunscreen may decrease rates of keratoma. Although studies are needed to validate the effectiveness of these interventions in the prevention of keratoma, these data should help clinicians, dermatologists, and patient advocates address the prevention of keratoma and other ocular skin cancers.

Anonymous Patient Answer

What is the primary cause of keratoma?

Because of the significant effect keratomas have on local and distant tumors, they are a concern when assessing patients with multiple carcinomas. The main factor that affects cancer incidence is the age of the patient, as the chances of developing a malignancy increase with age. While the risk of keratoma increases with age, the exact mechanism is unknown.

Anonymous Patient Answer

What does fractionated laser resurfacing usually treat?

The majority of patients in the study group had clinically improved corneas by the 12 month follow-up point, although their corneas remained stably improved after a similar length of time.

Anonymous Patient Answer

How quickly does keratoma spread?

The authors suggest that it may be difficult, even if keratoma is biopsied at an early stage, to determine whether it represents a pre-cancerous lesion. The patient must be clearly informed of the uncertainties of a diagnosis before the patient begins the process of making an informed decision.

Anonymous Patient Answer

Does keratoma run in families?

The positive correlation between incidence of keratoma and family history in this survey strongly suggests that an autosomal dominant gene may be involved in the process and may be associated with keratoma run in families.

Anonymous Patient Answer

Have there been any new discoveries for treating keratoma?

Although there are many treatments for this disease, new methods have to be found to be effective and safe. At present, all current approaches to treating it are based on eliminating the possibility of recurrence through surgical removal of the existing lesion. However, the lesions' recurrence rate is so low that this technique does not have sufficient power to ensure that it is successful in every case. It is, therefore, not appropriate for everybody. If this is the case, new alternative treatments and approaches will be explored for patients. At present, they have to be tried in order to seek answers that are more effective and more reliable, resulting in a more definitive end.

Anonymous Patient Answer
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