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Sympathetic Nervous System Analysis for Coronary Artery Dissection

N/A

Recruiting

Led By Marysia Tweet, MD, MS

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography

For controls: no cardiac disease history

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline

Awards & highlights

Study Summary

This trial will compare how the body reacts to stress and the health of arteries in people with SCAD to a control group.

Who is the study for?

This study is for individuals with a history of spontaneous coronary artery dissection (SCAD), confirmed by specific heart imaging tests, and healthy volunteers without any cardiac disease. Pregnant women, those with unstable heart conditions recently, or on certain blood thinners can't participate.Check my eligibility

What is being tested?

The trial investigates the sympathetic nervous system's activity (our body's fight or flight response) and arterial health in SCAD patients compared to healthy people using non-invasive tests like echocardiograms and carotid ultrasounds.See study design

What are the potential side effects?

Since this study uses non-invasive diagnostic tools rather than medications, side effects are minimal but may include discomfort from tight pressure during tonometry or temporary skin marks from elastography.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My SCAD diagnosis was confirmed through specific heart imaging tests.

Select...

I have never had heart disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Arterial stiffness

Arterial thickness

Baroreflex sensitivity

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Spontaneous coronary artery dissection (SCAD) groupExperimental Treatment6 Interventions

Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.

Group II: Healthy Control GroupExperimental Treatment6 Interventions

Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Echocardiogram

2016

Completed Phase 2

~1870

Elastography

2011

N/A

~720

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,216 Previous Clinical Trials

3,767,438 Total Patients Enrolled

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,840 Previous Clinical Trials

47,852,074 Total Patients Enrolled

Marysia Tweet, MD, MSPrincipal InvestigatorMayo Clinic

Media Library

Spontaneous coronary artery dissection (SCAD) group Clinical Trial Eligibility Overview. Trial Name: NCT05699200 — N/A

Coronary Artery Dissection Research Study Groups: Spontaneous coronary artery dissection (SCAD) group, Healthy Control Group

Coronary Artery Dissection Clinical Trial 2023: Spontaneous coronary artery dissection (SCAD) group Highlights & Side Effects. Trial Name: NCT05699200 — N/A

Spontaneous coronary artery dissection (SCAD) group 2023 Treatment Timeline for Medical Study. Trial Name: NCT05699200 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants is the research team recruiting for this investigation?

"Affirmative. Clinicaltrials.gov's information serves to corroborate that this clinical trial is still recruiting, having first been posted on June 1st 2023 and last updated on the 5th of the same month. This project looks for 50 individuals from a single medical facility."

Answered by AI

Are there still open enrollments for this research experiment?

"According to clinicaltrials.gov, the recruitment phase of this research is ongoing. This trial was first publicized on June 1st 2023 and had its most recent update 5 days later, on June 5th 2023."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Marysia Tweet 2023. "A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05699200.