Cognitive training for Heart Failure

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Heart Failure+2 More
Cognitive training - Other
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This trial will test whether physical and cognitive exercise can improve cognitive and brain health in people with heart failure, and whether sex affects these results.

Eligible Conditions
  • Heart Failure
  • Congestive heart failure
  • Aging

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 7 Secondary · Reporting Duration: Baseline and post-intervention at 6 months

Baseline
Cognitive reserve
Month 6
Change in 6-min walking test performance
Change in NT-pro-BNP
Change in anxiety
Change in cardiorespiratory fitness
Change in cerebral activity
Change in cerebral autoregulation - frontal cortical region
Change in cerebral autoregulation - middle cerebral arteries
Change in cerebral pulsatility - cortical frontal region
Change in cerebral pulsatility - middle cerebral arteries
Change in cerebral vasoreactivity - middle cerebral arteries
Change in cerebral vasoreactivity - prefrontal cortex
Change in depressive symptoms
Change in episodic memory
Change in executive functions
Change in general cognitive functioning
Change in high-sensitive Troponin T
Change in perceived self care behaviour
Change in processing speed
Change in quality of life
Change in sleep quality
Change in upper limb muscle strength
baseline
Genotyping data

Trial Safety

Safety Progress

1 of 3

Trial Design

3 Treatment Groups

Usual care
1 of 3
Exercise
1 of 3
Combined
1 of 3
Active Control
Experimental Treatment

216 Total Participants · 3 Treatment Groups

Primary Treatment: Cognitive training · No Placebo Group · N/A

ExerciseExperimental Group · 2 Interventions: Exercise training, Usual care · Intervention Types: Other, Other
CombinedExperimental Group · 3 Interventions: Cognitive training, Exercise training, Usual care · Intervention Types: Other, Other, Other
Usual care
Other
ActiveComparator Group · 1 Intervention: Usual care · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and post-intervention at 6 months

Who is running the clinical trial?

Montreal Heart InstituteLead Sponsor
112 Previous Clinical Trials
53,828 Total Patients Enrolled
20 Trials studying Heart Failure
4,226 Patients Enrolled for Heart Failure
The Montreal Health Innovations Coordinating Center (MHICC)OTHER
11 Previous Clinical Trials
9,686 Total Patients Enrolled
3 Trials studying Heart Failure
320 Patients Enrolled for Heart Failure
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,221 Previous Clinical Trials
24,403,041 Total Patients Enrolled
25 Trials studying Heart Failure
1,974,640 Patients Enrolled for Heart Failure
Louis Bherer, PhDPrincipal InvestigatorMontreal Heart Institute
8 Previous Clinical Trials
725 Total Patients Enrolled
1 Trials studying Heart Failure
54 Patients Enrolled for Heart Failure

Eligibility Criteria

Age 18+ · All Participants · 4 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 17th, 2021

Last Reviewed: October 9th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.