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Kinase Inhibitor

AZD6234 for Obesity

Phase 1
Recruiting
Research Sponsored by AstraZeneca
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1, day 15, day 36 and day 78
Awards & highlights

Study Summary

This trial looked at the health effects of a weight-loss drug in people who are overweight or obese.

Who is the study for?
This trial is for healthy men and women aged 18-55 who are overweight or obese (BMI between 25 and 40 kg/m2) but otherwise in good health. Women must not be able to bear children, either due to being postmenopausal or having undergone certain sterilization surgeries.Check my eligibility
What is being tested?
The study tests the safety and effects of a drug called AZD6234 on people who are overweight or obese. Participants will receive either AZD6234 or a placebo, which has no active ingredients, to compare outcomes.See study design
What are the potential side effects?
While specific side effects aren't listed here, common ones may include digestive issues, changes in appetite, fatigue, headaches, and potential allergic reactions. The exact side effects will be monitored throughout the trial.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1, day 15, day 36 and day 78
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1, day 15, day 36 and day 78 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of participants with Adverse Events (AEs) and Serious Adverse Events(SAE)
Secondary outcome measures
ADA titer
Area under concentration time curve in the dosing interval (AUCtau)
Area under plasma concentration-time curve from zero to infinity (AUCinf)
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Cohort 2Experimental Treatment2 Interventions
Participants will receive repeated doses of AZD6234 or placebo via SC injection
Group II: Cohort 1Experimental Treatment2 Interventions
Participants will receive repeated doses of AZD6234 or placebo via SC injection
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AZD6234
2022
Completed Phase 1
~60
Placebo
1995
Completed Phase 3
~2670

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

AstraZenecaLead Sponsor
4,272 Previous Clinical Trials
288,612,599 Total Patients Enrolled
ParexelIndustry Sponsor
304 Previous Clinical Trials
101,076 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I potentially be enrolled in this medical experiment?

"This clinical trial is searching for 56 healthy volunteers aged between 18 and 55. To be eligible, potential participants must meet the aforementioned criteria."

Answered by AI

Are there still available spots for prospective participants in this scientific trial?

"The data found on clinicaltrials.gov reveals that this medical trial, which was originally posted on November 11th 2023 and last updated the day prior, is no longer recruiting patients. Nevertheless, 1213 other studies are still actively seeking participants at this time."

Answered by AI

Are adults over 45 years of age being admitted to this trial?

"This particular medical study is seeking patients aged 18 to 55. In contrast, there are 120 trials available for applicants below the age of consent and 644 such clinical studies catered towards those over 65 years old."

Answered by AI

What perils might patients enrolled in Cohort 1 face?

"Since this is a Phase 1 clinical trial, with limited data supporting safety and efficacy of Cohort 1, our team at Power assigned it a score of 1 on the risk scale."

Answered by AI

Who else is applying?

What site did they apply to?
Research Site
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria

Why did patients apply to this trial?

I’ve tried to lose weight and nothing seems to work. I want to loose weight but I have problems because the menopause.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD6234 After Repeat Dose Administration in Participants Who Are Overweight or Obese
2023. "A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD6234 After Repeat Dose Administration in Participants Who Are Overweight or Obese". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06132841.
~51 spots leftby Apr 2025
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