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MRI Brain Fluid Imaging During Breathing Tasks

N/A
Recruiting
Led By Laura Lewis, PhD
Research Sponsored by Boston University Charles River Campus
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult age 18-70 years
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during study (2 hours)
Awards & highlights

Study Summary

This trial will use MRI to study how blood and cerebrospinal fluid flow in the brain changes during different breathing tasks and while the patient is receiving neuromodulation.

Who is the study for?
This trial is for healthy adults aged 18-70 who are not on brain-affecting meds, have no serious heart or brain conditions, no metal implants, and aren't pregnant. Participants must be under 250 pounds without claustrophobia and should have normal vision (with contacts if needed).Check my eligibility
What is being tested?
The study tests how breathing exercises and non-invasive nerve stimulation affect the flow of fluids in the brain using MRI scans. It aims to understand changes in blood flow and fluid dynamics during different breathing tasks.See study design
What are the potential side effects?
Potential side effects may include discomfort from wearing the stimulation device, mild headaches or fatigue after the procedure, skin irritation at electrode sites, and typical MRI-related issues like loud noises or warmth.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 70 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during study (2 hours)
This trial's timeline: 3 weeks for screening, Varies for treatment, and during study (2 hours) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cerebrospinal fluid (CSF) signals
functional magnetic resonance imaging (fMRI) signals
Secondary outcome measures
Heart rate
Pulse oximetry
Respiratory physiology amplitude
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Transcutaneous vagal nerve stimulationExperimental Treatment2 Interventions
Participants will receive transcutaneous vagal nerve stimulation in specific patterns.
Group II: Breath taskExperimental Treatment1 Intervention
Participants will breathe in specific patterns.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcutaneous vagal nerve stimulation
2016
Completed Phase 2
~230

Find a Location

Who is running the clinical trial?

National Center for Complementary and Integrative Health (NCCIH)NIH
832 Previous Clinical Trials
668,893 Total Patients Enrolled
Boston University Charles River CampusLead Sponsor
114 Previous Clinical Trials
12,210 Total Patients Enrolled
Laura Lewis, PhDPrincipal InvestigatorBoston University
1 Previous Clinical Trials
60 Total Patients Enrolled

Media Library

Breathing task Clinical Trial Eligibility Overview. Trial Name: NCT05180981 — N/A
Healthy Subjects Research Study Groups: Breath task, Transcutaneous vagal nerve stimulation
Healthy Subjects Clinical Trial 2023: Breathing task Highlights & Side Effects. Trial Name: NCT05180981 — N/A
Breathing task 2023 Treatment Timeline for Medical Study. Trial Name: NCT05180981 — N/A
Healthy Subjects Patient Testimony for trial: Trial Name: NCT05180981 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any remaining vacancies for participants in this experiment?

"Affirmative. Clinicaltrials.gov exhibits that the trial, which was initially posted on January 18th 2022, is currently looking for enrollees. The research seeks 80 individuals to be recruited from 2 medical hubs."

Answered by AI

Is maturity a factor in the selection process for this research endeavor?

"The trial only allows for participants aged 18 to 70, however there are 50 separate studies available for those under the age of majority and an additional 371 trials open to applicants over 65 years old."

Answered by AI

How many participants are engaging in this experiment?

"Affirmative. According to the records posted on clinicaltrials.gov, this trial initiated recruitment efforts in January of 2022 and is still actively seeking participants as of March 10th. There are 80 spots open across two different sites."

Answered by AI

What are the chief goals of this clinical experiment?

"The main metric of this two-hour trial is the fMRI signals. Secondary measurements are respiratory physiology, which will be measured in arbitrary units output by a sensor, and heart rate variability, quantified in milliseconds (ms)."

Answered by AI

Are there any restrictions to participation in this clinical trial?

"To be eligible for this clinical trial, individuals must meet the requirements of healthy subjects and possess an age between 18 and 70 years. The research team has a target recruitment pool size of 80 participants."

Answered by AI

Who else is applying?

What state do they live in?
New York
Pennsylvania
Other
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Massachusetts General Hospital
Boston University - Charles River Campus
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

to help science i can also travel to bu. I'm an athlete and I'm endlessly fascinated with how my body respond.
PatientReceived no prior treatments
I'm interested in clinical trials I just recently finished one in Tampa Florida I was living there and now I live in North Smithfield Rhode Island and I am interested in your trials so if you have anything good for me give me a call or give me my other phone number is 813-381-8400 or 401-808-2678 email t a m b o f 67@yahoo.com thank you for your time.
PatientReceived no prior treatments

How responsive is this trial?

Most responsive sites:
  1. Massachusetts General Hospital: < 24 hours
Typically responds via
Email
Average response time
  • < 1 Day
Recent research and studies
clinicaltrials.govStudy
Imaging Brain Fluids During Breathing
Laura Lewis 2022. "Imaging Brain Fluids During Breathing". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05180981.
~38 spots leftby Apr 2026
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