Procanbid

pre-excited atrial fibrillation, life-threatening ventricular arrhythmias, Supraventricular Arrhythmias + 1 more

Treatment

14 Active Studies for Procanbid

Treatment for

pre-excited atrial fibrillation

What is Procanbid

ProcainamideThe Generic name of this drug

Treatment SummaryA version of the drug procaine with fewer effects on the central nervous system.

Procainamide Hydrochlorideis the brand name

Procanbid Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procainamide Hydrochloride

Procainamide

1976

Effectiveness

How Procanbid Affects PatientsProcainamide is a medicine used to create local or regional anesthesia, and also to treat ventricular tachycardia that happens during heart surgery, catheterization, myocardial infarction, digitalis toxicity, or other cardiac diseases. It works similarly to procaine and quinidine by reducing the excitement of the ventricle and increasing the stimulation threshold during diastole. However, it does not affect the sinoatrial node.

How Procanbid works in the bodyProcainamide blocks sodium channels to stop the flow of electricity in your nerves. This helps to numb the area, providing a local anesthetic effect.

When to interrupt dosage

The proposed measure of Procanbid is contingent upon the recognized condition, including Supraventricular Arrhythmias, Ventricular Tachycardia and life-threatening ventricular arrhythmias. The dosage varies as per the administration strategy (e.g. Capsule, gelatin coated or Injection, solution - Intramuscular; Intravenous) featured in the table beneath.

Condition

Dosage

Administration

Supraventricular Arrhythmias

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Oral, Capsule, Capsule - Oral, Liquid, Liquid - Intramuscular; Intravenous, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral

Ventricular Tachycardia

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

life-threatening ventricular arrhythmias

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

pre-excited atrial fibrillation

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

Warnings

Procanbid Contraindications

Condition

Risk Level

Notes

Lupus

Do Not Combine

Complete Heart Block

Do Not Combine

Torsades de Pointes

Do Not Combine

There are 20 known major drug interactions with Procanbid.

Common Procanbid Drug Interactions

Drug Name

Risk Level

Description

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Procainamide is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Procainamide is combined with Artemether.

Asenapine

Major

The risk or severity of QTc prolongation can be increased when Procainamide is combined with Asenapine.

Clofarabine

Major

The serum concentration of Clofarabine can be increased when it is combined with Procainamide.

Dalfampridine

Major

The serum concentration of Dalfampridine can be increased when it is combined with Procainamide.

Procanbid Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats when administered intravenously is 95mg/kg, while in mice it is 312mg/kg when administered orally and 103mg/kg when administered intravenously. In rabbits, the lowest toxic dose is 250mg/kg when administered intravenously.

Procanbid Novel Uses: Which Conditions Have a Clinical Trial Featuring Procanbid?

17 active clinical trials are currently examining the potential of Procanbid to treat Ventricular Tachycardia, life-threatening ventricular arrhythmias and pre-excited atrial fibrillation.

Condition

Clinical Trials

Trial Phases

life-threatening ventricular arrhythmias

0 Actively Recruiting

Supraventricular Arrhythmias

0 Actively Recruiting

pre-excited atrial fibrillation

0 Actively Recruiting

Ventricular Tachycardia

15 Actively Recruiting

Phase 3, Phase 4, Early Phase 1, Not Applicable, Phase 2

Procanbid Reviews: What are patients saying about Procanbid?

5Patient Review

2/19/2008

Procanbid for Heart Ventricle Rhythm Problem

3Patient Review

3/15/2010

Procanbid for Osteoporosis

This treatment really helped me. I'm grateful for modern medicine.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about procanbid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is another name for procainamide?

"PRONESTYL is a medication indicated for the treatment of ventricular arrhythmias, such as sustained ventricular tachycardia, that are considered life-threatening by a physician."

Answered by AI

What is procainamide given for?

"Procainamide is administrated as an injection in order to treat irregular heartbeats and to slow an overactive heart. The heart will work more efficiently when it has a normal heartbeat (rhythm). Procainamide works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues."

Answered by AI

What are the side effects of procainamide?

"The most common side effects of Pronestyl are nausea, vomiting, loss of appetite, diarrhea, and bitter taste in the mouth. Other side effects include dizziness, tiredness, flushinh, itching or rash."

Answered by AI

What class of drug is procainamide?

"Procainamide is a medication that is used to manage and treat various types of arrhythmias. It is a Class 1A antiarrhythmic agent."

Answered by AI

Clinical Trials for Procanbid

Image of Medical University of Michigan in Ann Arbor, United States.

Have you considered Procanbid clinical trials? We made a collection of clinical trials featuring Procanbid, we think they might fit your search criteria.

Image of Hospital of the University of Pennsylvania in Philadelphia, United States.

Nerve Block for Heart Rhythm Problems

18+

All Sexes

Philadelphia, PA

This trial looks at whether a nerve block can help treat heart rhythm problems.

Phase < 1

Recruiting

Has No Placebo

Hospital of the University of Pennsylvania

Image of Cedars Cancer Center, McGill University Health Centre in Montreal, Canada.

Ablative Radiation for Ventricular Tachycardia

18+

All Sexes

Montreal, Canada

This trial will test a new treatment for ventricular tachycardia that uses ablative radiation. The goal is to minimize possible adverse events and radiation dose to surrounding healthy tissue while maintaining a clinical benefit.

Phase 2

Waitlist Available

Has No Placebo

Cedars Cancer Center, McGill University Health CentreMartin L Bernier, MD

Image of University of Ottawa Heart Institute in Ottawa, Canada.

Catheter vs Radio-Ablation for Ventricular Tachycardia

18+

All Sexes

Ottawa, Canada

This trialcompares an invasive procedure to non-invasive radio ablation to treat ventricular tachycardia, using a novel mapping tech.

Phase 3

Recruiting

Has No Placebo

University of Ottawa Heart InstituteCalum Redpath

Image of Nova Scotia Health Authority in Halifax, Canada.

SBRT for Ventricular Tachycardia

Any Age

All Sexes

Halifax, Canada

This trial is testing the use of SBRT to see if it can help people with VT that has not been helped by other treatments.

Recruiting

Has No Placebo

Nova Scotia Health AuthorityJohn Sapp, MD FRCPC

Have you considered Procanbid clinical trials? We made a collection of clinical trials featuring Procanbid, we think they might fit your search criteria.