Corvert

Atrial Fibrillation
Treatment
3 FDA approvals
20 Active Studies for Corvert

What is Corvert

IbutilideThe Generic name of this drug
Treatment SummaryIbutilide is an intravenous medication used to convert irregular heart rhythms, such as atrial flutter and atrial fibrillation, back to a regular rhythm. It is specifically approved to treat acute atrial flutter and recent onset atrial fibrillation in order to bring the heart rate back to normal sinus rhythm (NSR).
Corvertis the brand name
Corvert Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corvert
Ibutilide
1995
4

Approved as Treatment by the FDA

Ibutilide, also known as Corvert, is approved by the FDA for 3 uses which include Atrial Fibrillation and Atrial Fibrillation .
Atrial Fibrillation
Helps manage Atrial Fibrillation
Atrial Fibrillation
Helps manage Atrial Fibrillation
Atrial Flutter
Helps manage Atrial Flutter

Effectiveness

How Corvert Affects PatientsIbutilide affects the action potential and increases the time it takes for the heart to prepare for the next beat. This is done by activating a slow sodium current instead of blocking the potassium current like many other antiarrhythmic drugs. This can help to regulate the heartbeat.
How Corvert works in the bodyIbutilide is a type of drug used to treat irregular heart rhythms. It does this by binding to certain types of potassium and calcium channels in the heart and altering their activity. This helps restore the normal rhythm of the heart.

When to interrupt dosage

The prescribed dosage of Corvert is based upon the recognized condition. The degree of dosage can be seen in the table below, contingent upon the technique of delivery (e.g. Solution or Solution - Intravenous).
Condition
Dosage
Administration
Atrial Fibrillation
, 0.1 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous

Warnings

There are 20 known major drug interactions with Corvert.
Common Corvert Drug Interactions
Drug Name
Risk Level
Description
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Asenapine.
Astemizole
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Astemizole.
Cisapride
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Cisapride.
Corvert Toxicity & Overdose RiskOverdosing on this drug can lead to toxic effects on the central nervous system, such as drowsiness, rapid breathing, and seizures. In rats, the lethal dose was found to be greater than 50mg/kg, which is at least 250 times the maximum recommended human dose.

Corvert Novel Uses: Which Conditions Have a Clinical Trial Featuring Corvert?

159 active clinical trials are currently being conducted to investigate the potential of Corvert to mitigate Atrial Fibrillation.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
94 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Corvert Reviews: What are patients saying about Corvert?

5Patient Review
11/6/2008
Corvert for Atrial Fibrillation Electrically Shocked to Normal Rhythm
I had an IV push which was too fast for my system and I flatlined!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about corvert

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Corvert administered?

"CORVERT can be given without diluting it or can be mixed with 50 mL of another solution first. The other solution can be either 0.9% Sodium Chloride Injection or 5% Dextrose Injection."

Answered by AI

What type of drug is ibutilide?

"How does ibutilide work? Ibutilide is a class III antiarrhythmic drug that is injected into a vein to treat abnormal heart rhythms. It works by lengthening the time it takes for electrical impulses to travel through the heart. This can help to restore a normal heart rhythm."

Answered by AI

What injection is for AFIB?

"Corvert is an antiarrhythmic drug that primarily affects class III cardiac action potentials, which prolongs them. It is indicated for quickly converting atrial fibrillation or atrial flutter of recent onset to sinus rhythm."

Answered by AI

What is ibutilide used for?

"Ibutilide is a medication used to convert a heart rhythm abnormality called atrial flutter or atrial fibrillation to normal sinus rhythm. It can also be used off-label as a pretreatment for a procedure called electrocardioversion."

Answered by AI

Clinical Trials for Corvert

Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA
The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.
Phase 4
Waitlist Available
Inova Alexandria Hospital
Have you considered Corvert clinical trials? We made a collection of clinical trials featuring Corvert, we think they might fit your search criteria.Go to Trials
Image of Mission Cardiovascular Research Institute in Fremont, United States.

REGN7508 + REGN9933 for Atrial Fibrillation

18+
All Sexes
Fremont, CA
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Phase 2
Recruiting
Mission Cardiovascular Research Institute (+4 Sites)Clinical Trial ManagementRegeneron Pharmaceuticals
Image of The Cleveland Clinic in Cleveland, United States.

Metabolic Surgery for Atrial Fibrillation

18 - 80
All Sexes
Cleveland, OH
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030. Obesity and its comorbidities such as type 2 diabetes (T2DM), hypertension, and obstructive sleep apnea (OSA) are major risk factors for development and progression of AF. Metabolic and Bariatric Surgery (MBS) is the most effective currently available treatment for obesity. Patients typically lose 20 to 35 percent of body weight after surgery which is often sustained for many years. MBS can improve all 5 major risk factors of AF including obesity, hypertension, T2DM, OSA, and systemic inflammation. The purpose of the study is to understand if MBS can affect the severity of AF and the toll AF's symptoms take on patients.
Phase 4
Waitlist Available
The Cleveland ClinicAli AminaniEthicon, Inc.
Have you considered Corvert clinical trials? We made a collection of clinical trials featuring Corvert, we think they might fit your search criteria.Go to Trials
Image of UCSF Medical Center at Parnassus in San Francisco, United States.

Alcohol Abstinence for Atrial Fibrillation

18+
All Sexes
San Francisco, CA
Per the 2021 National Survey on Drug Use and Health administered by the U.S. Department of Health and Human Services, 85% of all American adults consume alcohol. Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 10 million individuals in U.S., comprising 4.5% of the adult population. Although alcohol abstinence clearly reduces AF in heavy drinkers, observational data comparing the health effects of limited consumption versus abstention are conflicting. The Mediterranean diet is one of the few that has demonstrated clear cardiovascular benefits in a randomized study-this diet allows for the consumption of red wine (or high polyphenol/ low alcohol alcohol), generally not more than one drink in 24 hours, with meals, avoiding spirits and binge drinking. The effect of the "Mediterranean drinking pattern" on AF risk compared to alcohol abstinence remains unknown. This single center, randomized, controlled trial aims to compare the effects of a digital health intervention to encourage durable alcohol abstinence versus allowing guideline-adherent moderate alcohol consumption on AF severity. The knowledge gained from this study may be used to determine optimal thresholds for alcohol use among AF patients.
Recruiting
Has No Placebo
UCSF Medical Center at ParnassusGregory M Marcus, MD, MAS
Image of VA Palo Alto Health Care System, Palo Alto, CA in Palo Alto, United States.

Zio XT® Patch for Atrial Fibrillation

65+
All Sexes
Palo Alto, CA
* The goal of the screening trial is to determine whether early screening for atrial fibrillation improves outcomes, including lowering the chance of death, hospitalization for stroke, blood clots, heart failure, heart attack, and severe bleeding reduces the risk of stroke or heart failure. * Atrial fibrillation is a common heart condition in which one of the heart chambers doesn't follow a normal rhythm. Blood clots can form as a result, and they can travel to the brain and cause strokes, or to other organs. * Almost everyone with atrial fibrillation is treated with drugs called anticoagulants ("blood thinners") to reduce the risk of stroke. These drugs also increase the risk of bleeding. * Testing for atrial fibrillation is usually done for patients who have symptoms of an irregular or unusually fast or slow heartbeat, often called "palpitations" or a sensation of the heart pounding or stopping for a short period of time. * What is not known is whether screening people who do not have symptoms of atrial fibrillation, but who are at above-average risk of getting atrial fibrillation, will reduce death, hospitalization for stroke, blood clots, heart failure more than it increases hospitalization for severe bleeding. * People who participate in the trial who are selected by chance to receive screening will wear a small heart-rate monitor (Zio Patch) on their skin for 14 days and then return it to the manufacturer. Their doctors will be notified about the results and will make decisions about any treatment to recommend. * The screening trial is expected to enroll about 24,000 VA patients nationwide and to last 7 years, but each person's active participation in the trial is completed after sending in the Zio Patch. After that, the study team will just collect information from the participant's electronic medical records.
Waitlist Available
Has No Placebo
VA Palo Alto Health Care System, Palo Alto, CAPaul A. Heidenreich, MD MS
Have you considered Corvert clinical trials? We made a collection of clinical trials featuring Corvert, we think they might fit your search criteria.Go to Trials
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