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What is Corvert
IbutilideThe Generic name of this drug
Treatment SummaryIbutilide is an intravenous medication used to convert irregular heart rhythms, such as atrial flutter and atrial fibrillation, back to a regular rhythm. It is specifically approved to treat acute atrial flutter and recent onset atrial fibrillation in order to bring the heart rate back to normal sinus rhythm (NSR).
Corvertis the brand name
Corvert Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corvert
Ibutilide
1995
4
Approved as Treatment by the FDA
Ibutilide, also known as Corvert, is approved by the FDA for 1 uses which include Atrial Fibrillation .Atrial Fibrillation
Helps manage Atrial Fibrillation
Effectiveness
How Corvert Affects PatientsIbutilide affects the action potential and increases the time it takes for the heart to prepare for the next beat. This is done by activating a slow sodium current instead of blocking the potassium current like many other antiarrhythmic drugs. This can help to regulate the heartbeat.
How Corvert works in the bodyIbutilide is a type of drug used to treat irregular heart rhythms. It does this by binding to certain types of potassium and calcium channels in the heart and altering their activity. This helps restore the normal rhythm of the heart.
When to interrupt dosage
The prescribed dosage of Corvert is based upon the recognized condition. The degree of dosage can be seen in the table below, contingent upon the technique of delivery (e.g. Solution or Solution - Intravenous).Condition
Dosage
Administration
Atrial Fibrillation
, 0.1 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous
Warnings
There are 20 known major drug interactions with Corvert.Common Corvert Drug Interactions
Drug Name
Risk Level
Description
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Asenapine.
Astemizole
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Astemizole.
Cisapride
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Cisapride.
Corvert Toxicity & Overdose RiskOverdosing on this drug can lead to toxic effects on the central nervous system, such as drowsiness, rapid breathing, and seizures. In rats, the lethal dose was found to be greater than 50mg/kg, which is at least 250 times the maximum recommended human dose.
Corvert Novel Uses: Which Conditions Have a Clinical Trial Featuring Corvert?
159 active clinical trials are currently being conducted to investigate the potential of Corvert to mitigate Atrial Fibrillation.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Corvert Reviews: What are patients saying about Corvert?
5Patient Review
11/6/2008 I had an IV push which was too fast for my system and I flatlined!
Patient Q&A Section about corvert
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How is Corvert administered?
"CORVERT can be given without diluting it or can be mixed with 50 mL of another solution first. The other solution can be either 0.9% Sodium Chloride Injection or 5% Dextrose Injection."
Answered by AI
What type of drug is ibutilide?
"How does ibutilide work? Ibutilide is a class III antiarrhythmic drug that is injected into a vein to treat abnormal heart rhythms. It works by lengthening the time it takes for electrical impulses to travel through the heart. This can help to restore a normal heart rhythm."
Answered by AI
What injection is for AFIB?
"Corvert is an antiarrhythmic drug that primarily affects class III cardiac action potentials, which prolongs them. It is indicated for quickly converting atrial fibrillation or atrial flutter of recent onset to sinus rhythm."
Answered by AI
What is ibutilide used for?
"Ibutilide is a medication used to convert a heart rhythm abnormality called atrial flutter or atrial fibrillation to normal sinus rhythm. It can also be used off-label as a pretreatment for a procedure called electrocardioversion."
Answered by AI