Cordarone

Atrial Fibrillation, Ventricular Fibrillation, Tachycardia, Ventricular + 2 more
Treatment
4 FDA approvals
20 Active Studies for Cordarone

What is Cordarone

AmiodaroneThe Generic name of this drug
Treatment SummaryAmiodarone is a medication used to treat irregular or abnormal heart rhythms. It is typically prescribed for life-threatening ventricular arrhythmias, as well as atrial fibrillation. This drug can be very powerful and has the potential to cause serious side effects, so it should only be used to treat its approved indications.
Cordaroneis the brand name
image of different drug pills on a surface
Cordarone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cordarone
Amiodarone
1985
144

Approved as Treatment by the FDA

Amiodarone, also known as Cordarone, is approved by the FDA for 4 uses like Tachycardia, Ventricular and Ventricular Fibrillation .
Tachycardia, Ventricular
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
Ventricular Fibrillation
Helps manage recurrent Ventricular fibrillation
recurrent hemodynamically unstable Ventricular tachycardia
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
recurrent Ventricular fibrillation
Helps manage recurrent Ventricular fibrillation

Effectiveness

How Cordarone Affects PatientsAmiodarone is an anti-arrhythmic drug that helps to prevent and treat irregular heartbeats. When given intravenously, it helps relax the muscles in the walls of the blood vessels, lowers the pressure of the blood, and increases the amount of blood the heart pumps. However, when taken orally, it does not have much of an effect on how much blood is pumped. Taking amiodarone also affects the QRS and QT intervals in the heart, and can cause thyroid problems due to the high levels of iodine in the drug. Controlled clinical trials have not shown that taking amiodarone orally increases
How Cordarone works in the bodyAmiodarone is a type of drug that helps to treat abnormal heart rhythms. It works by blocking potassium currents that help the heart muscle to repolarize after a contraction. This increases the time it takes for the heart to repolarize and prevents abnormal heart rhythms. Amiodarone also affects other parts of the body, such as beta-adrenergic receptors and calcium channels, which can lead to side effects such as low blood pressure, slowed heart rate, and abnormal rhythm in the heart. It can also affect receptors in the liver, leading to fatty changes, and it can bind to the thyroid receptor, potentially leading to

When to interrupt dosage

The proposed dose of Cordarone is contingent upon the diagnosed ailment, including recurrent Ventricular fibrillation, Tachycardia, Ventricular and Cardiothoracic Surgery. The amount of dosage fluctuates as per the administration approach (e.g. Tablet or Injection, solution - Intravenous) specified in the table beneath.
Condition
Dosage
Administration
Ventricular Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, Tablet - Oral, , Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Atrial Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, Tablet - Oral, , Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Ventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, Tablet - Oral, , Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Supraventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, Tablet - Oral, , Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Cardiothoracic Surgery
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, Tablet - Oral, , Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous

Warnings

Cordarone Contraindications
Condition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Syncope
Do Not Combine
Atrioventricular Block
Do Not Combine
pathologic fistula
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
There are 20 known major drug interactions with Cordarone.
Common Cordarone Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Amiodarone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Amiodarone.
3-isobutyl-1-methyl-7H-xanthine
Major
The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Amiodarone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Amiodarone.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Amiodarone.
Cordarone Toxicity & Overdose RiskThe highest dose of amiodarone found to be non-toxic in mice and rats is 3,000 mg/kg. Overdosing on amiodarone can be fatal, as it can lead to irregular heartbeat, low blood pressure, shock, slow heartbeat, or damage to the liver. Treatment for an overdose may include fluids, medicines that raise blood pressure, or drugs that increase the strength of the heart's contractions. In some cases, a pacemaker may also be needed. Since amiodarone cannot be removed from the body through dialysis, regular liver function tests are recommended.
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Cordarone Novel Uses: Which Conditions Have a Clinical Trial Featuring Cordarone?

161 active clinical trials are currently being conducted to investigate the potential of Cordarone to mitigate recurrent Ventricular fibrillation, Cardiothoracic Surgery and Ventricular Tachycardia.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
94 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Tachycardia, Ventricular
0 Actively Recruiting
Tachycardia, Supraventricular
0 Actively Recruiting
Cardiothoracic Surgery
0 Actively Recruiting
Ventricular Fibrillation
0 Actively Recruiting

Cordarone Reviews: What are patients saying about Cordarone?

5Patient Review
9/8/2009
Cordarone for Life-Threatening Rapid Ventricular Heartbeat
I had been taking Amio for about a year with great results- no episodes of VT. But then I went in for a lung test and found out that the drug was causing my lungs to not work properly. I had to stop taking it immediately, and 30 days later I had an episode of VT which caused my ICD to fire.
4.7Patient Review
7/8/2010
Cordarone for Atrial Fibrillation
The side effects of this medication are so bad that I'm actually going back to the cardiologist today. I would not recommend it to anyone, even as a last resort.
4.3Patient Review
1/6/2015
Cordarone for Atrial Fibrillation
In the three months I've been taking this medication, I've only had one short episode of atrial fibrillation.
4.3Patient Review
7/20/2010
Cordarone for Atrial Fibrillation
I take Amio for post-open heart surgery and it has given me more acid indigestion. I realized that this is because Amio contains HCL, which is basically stomach acid. This has been a problem for me in the past, and now I know why Amio is bothering me. Pepto Bismal tablets help, but I might need something stronger.
3.7Patient Review
9/29/2008
Cordarone for Rapid Ventricular Heartbeat
I had a terrible reaction to the sun while taking this medication, so I had to stop. However, it does seem to have gotten rid of my fibrillations.
3.3Patient Review
2/9/2014
Cordarone for Atrial Fibrillation
I felt dizzy and lightheaded after taking this medication.
3Patient Review
9/19/2008
Cordarone for Atrial Fibrillation
2.7Patient Review
4/24/2016
Cordarone for Prevention of Recurrent Atrial Fibrillation
After using this medication, I was left feeling breathless and unable to walk any distance without becoming winded.
1.7Patient Review
4/25/2010
Cordarone for Prevention of Ventricular Fibrillation
I unfortunately experienced a lot of negative side effects from this medication, including sun sensitivity, reduced lung function, hypothyroidism, thinning hair, and blurred vision. My health overall has worsened since taking this drug.
1.7Patient Review
11/23/2009
Cordarone for Atrial Fibrillation
I would not recommend this drug to anyone. It killed my mother and I believe it's responsible for the death of many others.
1.3Patient Review
1/21/2013
Cordarone for Atrial Fibrillation
As this is a new drug for this particular problem, I unfortunately cannot speak to its efficacy. However, I can say that it did not help with my other issues.
1Patient Review
9/8/2009
Cordarone for Atrial Fibrillation
I suffered from SVT's for two years and was constantly in fear of an attack. I was finally given this medication while hospitalized for SVT and respiratory failure. The doctors were able to get my tachycardia under control with this med, and I've been on it for around 4 years now.
1Patient Review
3/24/2011
Cordarone for Atrial Fibrillation
My husband died after being given this drug during heart surgery. We were not warned of the risks or given any other options. I believe that any doctor who prescribes this medication is complicit in murder.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cordarone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Cordarone used for?

"Amiodarone is a drug used to treat and prevent an irregular heartbeat. It slows down nerve activity in the heart and relaxes an overactive heart."

Answered by AI

What are the side effects of Cordarone?

"The following are symptoms: nausea, vomiting, constipation, weight loss, fatigue, pulmonary fibrosis, heart block, and heart failure."

Answered by AI

What type of drug is Cordarone?

"CORDARONE (amiodarone HCl) is a drug used to treat irregular heartbeats, available as a pink, scored tablet. Each tablet contains 200 mg of amiodarone hydrochloride. Other inactive ingredients present are colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and FD&C Red 40."

Answered by AI

Does Cordarone affect blood pressure?

"Amiodarone not only prevents irregular heartbeats, but also widens blood vessels. This can lead to lower blood pressure. Since this is also beneficial for patients with congestive heart failure, amiodarone may help these patients as well."

Answered by AI

Clinical Trials for Cordarone

Have you considered Cordarone clinical trials? We made a collection of clinical trials featuring Cordarone, we think they might fit your search criteria.Go to Trials
Image of The Cleveland Clinic in Cleveland, United States.

Metabolic Surgery for Atrial Fibrillation

18 - 80
All Sexes
Cleveland, OH
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030. Obesity and its comorbidities such as type 2 diabetes (T2DM), hypertension, and obstructive sleep apnea (OSA) are major risk factors for development and progression of AF. Metabolic and Bariatric Surgery (MBS) is the most effective currently available treatment for obesity. Patients typically lose 20 to 35 percent of body weight after surgery which is often sustained for many years. MBS can improve all 5 major risk factors of AF including obesity, hypertension, T2DM, OSA, and systemic inflammation. The purpose of the study is to understand if MBS can affect the severity of AF and the toll AF's symptoms take on patients.
Phase 4
Waitlist Available
The Cleveland ClinicAli AminaniEthicon, Inc.
Image of The Ottawa Hospital Civic Campus in Ottawa, Canada.

Cardiac CT Angiography for Atrial Fibrillation and Flutter

18+
All Sexes
Ottawa, Canada
The goal of this randomized clinical trial is to learn whether patients with symptomatic atrial fibrillation or atrial flutter (AF) who require heart imaging to rule out a blood clot before cardioversion would benefit from cardiac computed tomography angiography (CCT) in the emergency department (ED) compared to current standard of care management. This will be a multicenter trial evaluating whether CCT-facilitated cardioversion in the ED reduces hospital admission, reduces repeat presentations to hospital and improves patient quality of life compared to the current standard of care. Participants will undergo CCT-facilitated cardioversion or be treated according to current standard of care while in the ED and complete quality of life questionnaires in the ED and follow-up at 30 days.
Waitlist Available
Has No Placebo
The Ottawa Hospital Civic CampusBenjamin Chow, MD PhD FRCPC FACC FESC FA
Have you considered Cordarone clinical trials? We made a collection of clinical trials featuring Cordarone, we think they might fit your search criteria.Go to Trials
Image of VA Palo Alto Health Care System, Palo Alto, CA in Palo Alto, United States.

Zio XT® Patch for Atrial Fibrillation

65+
All Sexes
Palo Alto, CA
* The goal of the screening trial is to determine whether early screening for atrial fibrillation improves outcomes, including lowering the chance of death, hospitalization for stroke, blood clots, heart failure, heart attack, and severe bleeding reduces the risk of stroke or heart failure. * Atrial fibrillation is a common heart condition in which one of the heart chambers doesn't follow a normal rhythm. Blood clots can form as a result, and they can travel to the brain and cause strokes, or to other organs. * Almost everyone with atrial fibrillation is treated with drugs called anticoagulants ("blood thinners") to reduce the risk of stroke. These drugs also increase the risk of bleeding. * Testing for atrial fibrillation is usually done for patients who have symptoms of an irregular or unusually fast or slow heartbeat, often called "palpitations" or a sensation of the heart pounding or stopping for a short period of time. * What is not known is whether screening people who do not have symptoms of atrial fibrillation, but who are at above-average risk of getting atrial fibrillation, will reduce death, hospitalization for stroke, blood clots, heart failure more than it increases hospitalization for severe bleeding. * People who participate in the trial who are selected by chance to receive screening will wear a small heart-rate monitor (Zio Patch) on their skin for 14 days and then return it to the manufacturer. Their doctors will be notified about the results and will make decisions about any treatment to recommend. * The screening trial is expected to enroll about 24,000 VA patients nationwide and to last 7 years, but each person's active participation in the trial is completed after sending in the Zio Patch. After that, the study team will just collect information from the participant's electronic medical records.
Waitlist Available
Has No Placebo
VA Palo Alto Health Care System, Palo Alto, CAPaul A. Heidenreich, MD MS
Image of VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA in Boston, United States.

Apixaban vs Rivaroxaban for Atrial Fibrillation

65+
All Sexes
Boston, MA
* The trial will compare two anticoagulants ("blood thinners") that are currently used in the VA and are considered standard care to prevent strokes in patients with atrial fibrillation. The two most commonly-used anticoagulants will be compared: apixaban (Eliquis) and rivaroxaban (Xarelto). They are considered by many doctors to have similar benefits and risks, but no one knows for sure. * The trial only enrolls patients with a diagnosis of atrial fibrillation ("A Fib"). * We will measure, in about 10,000 VA patients nationally, whether the rates of stroke, major bleeding, or death differ between these two drugs. * The trial will last about 7 years, but after the first prescription, all information will be collected from electronic medical records.
Phase 4
Waitlist Available
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MACara N Pellegrini
Have you considered Cordarone clinical trials? We made a collection of clinical trials featuring Cordarone, we think they might fit your search criteria.Go to Trials
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