Cordarone

Atrial Fibrillation, recurrent Ventricular fibrillation, Tachycardia, Ventricular + 2 more
Treatment
2 FDA approvals
20 Active Studies for Cordarone

What is Cordarone

AmiodaroneThe Generic name of this drug
Treatment SummaryAmiodarone is a medication used to treat irregular or abnormal heart rhythms. It is typically prescribed for life-threatening ventricular arrhythmias, as well as atrial fibrillation. This drug can be very powerful and has the potential to cause serious side effects, so it should only be used to treat its approved indications.
Cordaroneis the brand name
image of different drug pills on a surface
Cordarone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cordarone
Amiodarone
1985
144

Approved as Treatment by the FDA

Amiodarone, also known as Cordarone, is approved by the FDA for 2 uses like Tachycardia, Ventricular and recurrent Ventricular fibrillation .
Tachycardia, Ventricular
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
recurrent Ventricular fibrillation
Helps manage recurrent Ventricular fibrillation

Effectiveness

How Cordarone Affects PatientsAmiodarone is an anti-arrhythmic drug that helps to prevent and treat irregular heartbeats. When given intravenously, it helps relax the muscles in the walls of the blood vessels, lowers the pressure of the blood, and increases the amount of blood the heart pumps. However, when taken orally, it does not have much of an effect on how much blood is pumped. Taking amiodarone also affects the QRS and QT intervals in the heart, and can cause thyroid problems due to the high levels of iodine in the drug. Controlled clinical trials have not shown that taking amiodarone orally increases
How Cordarone works in the bodyAmiodarone is a type of drug that helps to treat abnormal heart rhythms. It works by blocking potassium currents that help the heart muscle to repolarize after a contraction. This increases the time it takes for the heart to repolarize and prevents abnormal heart rhythms. Amiodarone also affects other parts of the body, such as beta-adrenergic receptors and calcium channels, which can lead to side effects such as low blood pressure, slowed heart rate, and abnormal rhythm in the heart. It can also affect receptors in the liver, leading to fatty changes, and it can bind to the thyroid receptor, potentially leading to

When to interrupt dosage

The proposed dose of Cordarone is contingent upon the diagnosed ailment, including recurrent Ventricular fibrillation, Tachycardia, Ventricular and Cardiothoracic Surgery. The amount of dosage fluctuates as per the administration approach (e.g. Tablet or Injection, solution - Intravenous) specified in the table beneath.
Condition
Dosage
Administration
Atrial Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Ventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
recurrent Ventricular fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Cardiothoracic Surgery
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Supraventricular Tachycardia (SVT)
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous

Warnings

Cordarone Contraindications
Condition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Syncope
Do Not Combine
third degree AV block
Do Not Combine
pathologic fistula
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
There are 20 known major drug interactions with Cordarone.
Common Cordarone Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Amiodarone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Amiodarone.
3-isobutyl-1-methyl-7H-xanthine
Major
The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Amiodarone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Amiodarone.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Amiodarone.
Cordarone Toxicity & Overdose RiskThe highest dose of amiodarone found to be non-toxic in mice and rats is 3,000 mg/kg. Overdosing on amiodarone can be fatal, as it can lead to irregular heartbeat, low blood pressure, shock, slow heartbeat, or damage to the liver. Treatment for an overdose may include fluids, medicines that raise blood pressure, or drugs that increase the strength of the heart's contractions. In some cases, a pacemaker may also be needed. Since amiodarone cannot be removed from the body through dialysis, regular liver function tests are recommended.
image of a doctor in a lab doing drug, clinical research

Cordarone Novel Uses: Which Conditions Have a Clinical Trial Featuring Cordarone?

161 active clinical trials are currently being conducted to investigate the potential of Cordarone to mitigate recurrent Ventricular fibrillation, Cardiothoracic Surgery and Ventricular Tachycardia.
Condition
Clinical Trials
Trial Phases
Tachycardia, Ventricular
0 Actively Recruiting
recurrent Ventricular fibrillation
0 Actively Recruiting
Supraventricular Tachycardia (SVT)
1 Actively Recruiting
Not Applicable
Cardiothoracic Surgery
0 Actively Recruiting
Atrial Fibrillation
151 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1

Cordarone Reviews: What are patients saying about Cordarone?

5Patient Review
9/8/2009
Cordarone for Life-Threatening Rapid Ventricular Heartbeat
I had been taking Amio for about a year with great results- no episodes of VT. But then I went in for a lung test and found out that the drug was causing my lungs to not work properly. I had to stop taking it immediately, and 30 days later I had an episode of VT which caused my ICD to fire.
4.7Patient Review
7/8/2010
Cordarone for Atrial Fibrillation
The side effects of this medication are so bad that I'm actually going back to the cardiologist today. I would not recommend it to anyone, even as a last resort.
4.3Patient Review
1/6/2015
Cordarone for Atrial Fibrillation
In the three months I've been taking this medication, I've only had one short episode of atrial fibrillation.
4.3Patient Review
7/20/2010
Cordarone for Atrial Fibrillation
I take Amio for post-open heart surgery and it has given me more acid indigestion. I realized that this is because Amio contains HCL, which is basically stomach acid. This has been a problem for me in the past, and now I know why Amio is bothering me. Pepto Bismal tablets help, but I might need something stronger.
3.7Patient Review
9/29/2008
Cordarone for Rapid Ventricular Heartbeat
I had a terrible reaction to the sun while taking this medication, so I had to stop. However, it does seem to have gotten rid of my fibrillations.
3.3Patient Review
2/9/2014
Cordarone for Atrial Fibrillation
I felt dizzy and lightheaded after taking this medication.
3Patient Review
9/19/2008
Cordarone for Atrial Fibrillation
2.7Patient Review
4/24/2016
Cordarone for Prevention of Recurrent Atrial Fibrillation
After using this medication, I was left feeling breathless and unable to walk any distance without becoming winded.
1.7Patient Review
4/25/2010
Cordarone for Prevention of Ventricular Fibrillation
I unfortunately experienced a lot of negative side effects from this medication, including sun sensitivity, reduced lung function, hypothyroidism, thinning hair, and blurred vision. My health overall has worsened since taking this drug.
1.7Patient Review
11/23/2009
Cordarone for Atrial Fibrillation
I would not recommend this drug to anyone. It killed my mother and I believe it's responsible for the death of many others.
1.3Patient Review
1/21/2013
Cordarone for Atrial Fibrillation
As this is a new drug for this particular problem, I unfortunately cannot speak to its efficacy. However, I can say that it did not help with my other issues.
1Patient Review
9/8/2009
Cordarone for Atrial Fibrillation
I suffered from SVT's for two years and was constantly in fear of an attack. I was finally given this medication while hospitalized for SVT and respiratory failure. The doctors were able to get my tachycardia under control with this med, and I've been on it for around 4 years now.
1Patient Review
3/24/2011
Cordarone for Atrial Fibrillation
My husband died after being given this drug during heart surgery. We were not warned of the risks or given any other options. I believe that any doctor who prescribes this medication is complicit in murder.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cordarone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Cordarone used for?

"Amiodarone is a drug used to treat and prevent an irregular heartbeat. It slows down nerve activity in the heart and relaxes an overactive heart."

Answered by AI

What are the side effects of Cordarone?

"The following are symptoms: nausea, vomiting, constipation, weight loss, fatigue, pulmonary fibrosis, heart block, and heart failure."

Answered by AI

What type of drug is Cordarone?

"CORDARONE (amiodarone HCl) is a drug used to treat irregular heartbeats, available as a pink, scored tablet. Each tablet contains 200 mg of amiodarone hydrochloride. Other inactive ingredients present are colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and FD&C Red 40."

Answered by AI

Does Cordarone affect blood pressure?

"Amiodarone not only prevents irregular heartbeats, but also widens blood vessels. This can lead to lower blood pressure. Since this is also beneficial for patients with congestive heart failure, amiodarone may help these patients as well."

Answered by AI

Clinical Trials for Cordarone

Have you considered Cordarone clinical trials? We made a collection of clinical trials featuring Cordarone, we think they might fit your search criteria.
Have you considered Cordarone clinical trials? We made a collection of clinical trials featuring Cordarone, we think they might fit your search criteria.
Have you considered Cordarone clinical trials? We made a collection of clinical trials featuring Cordarone, we think they might fit your search criteria.