Treatment for Interstitial Lung Diseases (ILD)

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Duke University Medical Center, Durham, NC
Interstitial Lung Diseases (ILD)+2 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a new imaging technique may help detect changes in interstitial lung disease.

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Eligible Conditions

  • Interstitial Lung Diseases (ILD)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 5 primary outcomes in patients with Interstitial Lung Diseases (ILD). Measurement will happen over the course of 4 years.

4 years
Coefficient of repeatability of RBC/barrier signal ratio (unitless).
Echo time to separate RBC and barrier signals by 90 degrees (ms).
Population-wide RBC/barrier signal ratio (unitless).
RBC/barrier signal ratio (unitless).
Thoracic cavity volume measured in liters.

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Patients with Interstitial Lung Disease
1 of 2
Healthy Volunteers
1 of 2
Active Control

This trial requires 147 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Patients with Interstitial Lung Disease
Drug
Healthy Volunteers
Drug

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 4 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 4 years for reporting.

Closest Location

Duke University Medical Center - Durham, NC

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Inclusion/

Patient Q&A Section

Can pneumonia, interstitial be cured?

"This method is not recommended for routine use in clinical practice. In particular, it makes no sense to treat patients' pneumonia with the same antibiotic therapy as they have suffered for many weeks already. It has to be noted furthermore that the risk factors for pneumonia or interstitial pneumonia were identified, but the number of patients was too small for statistical inference." - Anonymous Online Contributor

Unverified Answer

What causes pneumonia, interstitial?

"This article presents, in order of significance to the treatment of pneumonia, the probable reasons for the development of this condition. These include factors inherent to infection, the immune response, environmental factors, and the mechanisms by which cells of the immune system interact with each other and are made functional. In some cases, a combination of factors is required to allow an infection to be properly treated. For example, an important role for the host's immune system is to combat infection and to help to prevent its persistence in the body. Other factors are required to allow successful treatment of an infection, including the use of antimicrobial agents and the healing of the disease when it has occurred. An important part of treatment is to permit the patient to breathe adequately." - Anonymous Online Contributor

Unverified Answer

How many people get pneumonia, interstitial a year in the United States?

"Between 450,000 and 750,000 Americans get pneumonia, interstitial, each year. This is a serious health problem that can be prevented by vaccinations against pneumococcal and other common respiratory infections." - Anonymous Online Contributor

Unverified Answer

What is pneumonia, interstitial?

"Interstitial pneumonia was the most common cause of pneumonia in infants under the age of one year. Although the causes of other types of pneumonia, such as atypical pneumonia, are not clear, one potential cause is pulmonary aspiration of gastric content." - Anonymous Online Contributor

Unverified Answer

What are the signs of pneumonia, interstitial?

"Coughing up blood, lethargy, confusion and feeling unwell, weight loss and weakness are indicative of pneumonia. Fever and shortness of breath are suggestive of pneumonia. On examination it may be possible to identify changes suggestive of pleural effusion due to interstitial pneumonia." - Anonymous Online Contributor

Unverified Answer

What are common treatments for pneumonia, interstitial?

"Aspirin is the drug most commonly used in the setting of pneumonia. Many clinicians also treat pneumonia with antibiotics, such as penicillin, erythromycin, and doxycycline (which is effective against gram-positive organisms). Ciprofloxacin (which is effective against MRSA) may alternatively be used for some people who acquire this infection in the hospital setting. The use of amoxicillin/clavulanate or a macrolide in conjunction with azithromycin can be more effective than azithromycin alone." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for pneumonia, interstitial?

"Although there are clear medical indications for and the safety of clinical trials for pneumonia, one of the main objections to the ethics of trial is that they provide insufficiently balanced information to patients and medical professionals. The reasons for this are discussed." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating pneumonia, interstitial?

"A variety of treatments, and combinations of treatments, have been shown to be effective for the treatment of pneumonia, Interstitial. There are many different clinical trials in progress for each treatment, but there does not seem to be quite a lot of consensus on the best treatment for pneumonia, Interstitial. [There is not enough clinical evidence that any new treatment has more benefits, or less disadvantages, than other treatments in treating pneumonia, Interstitial." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets pneumonia, interstitial?

"This is an alarming situation because there are still no effective treatment options for H1N1 infection among adults. Many healthcare professionals are unfamiliar with the pathogenesis of H1N1 influenza, and the treatment protocols for this infection in other regions. When a influenza infection presents itself, the [medication treatment of choice is usually a combination of amantadine/riviraprazan treatment, which are both effective against influenza A and B viruses,] and oseltamivir]. People are generally advised to stay home until the influenza vaccination is complete. Therefore, an understanding by the general public [of the severity of H1N1 infection] will help the healthcare providers develop more efficient policies and treatment protocols for this infection." - Anonymous Online Contributor

Unverified Answer

Has treatment proven to be more effective than a placebo?

"The current study showed clinical benefits from a low dose of prednisolone for patients with PAP, especially when combined with the use of an ABPA. Thus, we suggest applying low doses of prednisolone in PAP patients, particularly those treated with steroids only in the past, as combination therapy with ABPA." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"This questionnaire highlights the importance of defining the usual treatment for uncomplicated infections or pneumonia and the potential impact it is to obtain a correct treatment plan." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of treatment?

"The most common side effects of antivirals are headache, gastrointestinal irritation and diarrhea. The most common side effects of oseltamivir from two randomized controlled trials were headache (10% vs. 0%), itchiness (9% vs. 9%) and diarrhoea (4% vs. 0%). In the study on oseltamivir, headache worsened about the fifth day at the conclusion. Diarrhoea increased almost twofold compared with baseline." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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