Reviewed by Michael Gill, B. Sc.
25 Congestive Heart Failure Clinical Trials Near Me
Top Hospitals for Congestive Heart Failure Clinical Trials
Image of Weill Cornell Medicine in New York.
Weill Cornell Medicine
New York
4Active Trials
4All Time Trials for Congestive Heart Failure
2021First Congestive Heart Failure Trial
Image of Lancaster General Hospital in Pennsylvania.
Lancaster General Hospital
Lancaster
3Active Trials
3All Time Trials for Congestive Heart Failure
2018First Congestive Heart Failure Trial
Top Cities for Congestive Heart Failure Clinical Trials
Top Treatments for Congestive Heart Failure Clinical Trials
Treatment Name
Active Congestive Heart Failure Clinical Trials
All Time Trials for Congestive Heart Failure
First Recorded Congestive Heart Failure Trial
Beta Blocker BABA Sequence
2
2
2021
Beta Blocker ABAB Sequence
1
1
2022
Patients 65 and older with Heart Failure with Preserved Ejection Fraction
1
1
2020
Corvia Atrial Shunt System / IASD System II
1
1
2022
Avmacol ES
1
1
2022

What Are Congestive Heart Failure Clinical Trials?

Congestive heart failure, more commonly known as heart failure, is a complex condition that results from a functional or structural heart disorder impairing ventricular filling or ejection of blood to the systemic circulation. It doesn’t mean the heart has failed or stopped working, but it isn’t pumping blood as efficiently.

Congestive heart failure is caused by structural and functional heart abnormalities and other triggering factors. Historically, most cases were due to coronary artery disease and myocardial infarction.

Many congestive heart failure clinical trials include analyzing the effects of different drugs and treatments to reduce patient mortality and morbidity.

Why Is Congestive Heart Failure Being Studied Through Clinical Trials?

About 6.2 million adults in the United States have heart failure. Moreover, heart failure cost the nation an estimated $30.7 billion in 2012, including health care services, medicines, and missed work days.

Heart failure can lead to multiple complications, such as kidney and liver damage, malnutrition, irregular heartbeat, sudden cardiac arrest, pulmonary hypertension, and heart valve problems.

What Are The Types of Treatments Available For Congestive Heart Failure?

For most patients, congestive heart failure is a long-term condition that cannot be cured. But there are multiple treatments available that help control the symptoms. For instance, pharmacotherapy is most commonly recommended, and patients often take 2 to 3 medications like ACE inhibitors, beta-blockers, diuretics, ivabradine, etc.

Some new therapeutic agents have become a standard for heart failure treatment. For instance, a specific cardiac myosin activator, omecamtiv mecarbil, binds to the catalytic domain of myosin with high affinity and shifts the equilibrium of ATP hydrolysis toward ADP-P during the stroke. Another drug, Tolvaptan, is an oral vasopressin type 2 receptor antagonist that affects collecting ducts and increases aquaresis. It increases sodium levels in patients with hyponatremia.

What Are Some Recent Breakthrough Clinical Trials For Congestive Heart Failure?

2015: Peritoneal Dialysis - this study suggests that patients tolerate the gentle rate of fluid removal through peritoneal dialysis. Recent publications suggest a positive impact of starting peritoneal dialysis in patients with cardiorenal syndrome type 2 on the hospitalization rate, functional status, and quality of life.

2019: Application of G-CSF - this study concludes that GCSF exerts its beneficial effects on cardiac repair through either stem cell mobilization or direct angiogenesis promotion, all of which can promote cardiac cell repair. GCSF is a promising target in CHF therapy and can be used in clinical practice.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting Congestive Heart Failure Clinical Trial Research?

National Heart, Lung, And Blood Institute (NHLBI)

NHLBI aims to improve heart failure diagnosis, treatment, and prevention. Multiple studies impacted the community, such as cellular therapies, risk factors for heart failure with preserved ejection fraction (HFpEF), and practical and affordable medicines.

Winters Center for Heart Failure Research

The Winters Center is a fully integrated heart failure research program that develops, designs, and conducts basic and clinical research studies. It translates new and novel technologies from the laboratory bench into clinical practice.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 8th, 2021

Last Reviewed: November 27th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References1 Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation. 2012 Jan 3;125(1):e2-e220. doi: 10.1161/CIR.0b013e31823ac046. Epub 2011 Dec 15. Erratum in: Circulation. 2012 Jun 5;125(22):e1002. https://pubmed.ncbi.nlm.nih.gov/221795392 Roberts ME, Neville E, Berrisford RG, Antunes G, Ali NJ; BTS Pleural Disease Guideline Group. Management of a malignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010 Aug;65 Suppl 2:ii32-40. doi: 10.1136/thx.2010.136994. https://pubmed.ncbi.nlm.nih.gov/206966913 Davies HE, Mishra EK, Kahan BC, Wrightson JM, Stanton AE, Guhan A, Davies CW, Grayez J, Harrison R, Prasad A, Crosthwaite N, Lee YC, Davies RJ, Miller RF, Rahman NM. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial. JAMA. 2012 Jun 13;307(22):2383-9. doi: 10.1001/jama.2012.5535. https://pubmed.ncbi.nlm.nih.gov/226105204 Abraham WT, Kuck KH, Goldsmith RL, Lindenfeld J, Reddy VY, Carson PE, Mann DL, Saville B, Parise H, Chan R, Wiegn P, Hastings JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, Tomassoni GF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuß G. A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation. JACC Heart Fail. 2018 Oct;6(10):874-883. doi: 10.1016/j.jchf.2018.04.010. Epub 2018 May 10. https://pubmed.ncbi.nlm.nih.gov/297548125 Cikes M, Claggett B, Shah AM, Desai AS, Lewis EF, Shah SJ, Anand IS, O'Meara E, Rouleau JL, Sweitzer NK, Fang JC, Saksena S, Pitt B, Pfeffer MA, Solomon SD. Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: The TOPCAT Trial. JACC Heart Fail. 2018 Aug;6(8):689-697. doi: 10.1016/j.jchf.2018.05.005. Epub 2018 Jul 11. https://pubmed.ncbi.nlm.nih.gov/300075576 Porcel JM, Light RW. Diagnostic approach to pleural effusion in adults. Am Fam Physician. 2006 Apr 1;73(7):1211-20. Review. https://pubmed.ncbi.nlm.nih.gov/166232087 Light RW, Macgregor MI, Luchsinger PC, Ball WC Jr. Pleural effusions: the diagnostic separation of transudates and exudates. Ann Intern Med. 1972 Oct;77(4):507-13. https://pubmed.ncbi.nlm.nih.gov/46427318 Cikes M, Claggett B, Shah AM, Desai AS, Lewis EF, Shah SJ, Anand IS, O'Meara E, Rouleau JL, Sweitzer NK, Fang JC, Saksena S, Pitt B, Pfeffer MA, Solomon SD. Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: The TOPCAT Trial. JACC Heart Fail. 2018 Aug;6(8):689-697. doi: 10.1016/j.jchf.2018.05.005. Epub 2018 Jul 11. https://pubmed.ncbi.nlm.nih.gov/300075579 Porcel JM, Light RW. Diagnostic approach to pleural effusion in adults. Am Fam Physician. 2006 Apr 1;73(7):1211-20. Review. https://pubmed.ncbi.nlm.nih.gov/1662320810 Light RW. Clinical practice. Pleural effusion. N Engl J Med. 2002 Jun 20;346(25):1971-7. https://pubmed.ncbi.nlm.nih.gov/12075059