What is Quinidex
QuinidineThe Generic name of this drug
Treatment SummaryQuinidine is an alkaloid derived from the bark of the Cinchona tree. It is an optical isomer of quinine. The drug works by blocking sodium and potassium currents in the body, which helps to reduce the excitability of muscles, making them less active. It also blocks certain nerve signals, preventing them from reaching their targets.
Quinidine Gluconateis the brand name
Quinidex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinidine Gluconate
Quinidine
1950
24
Approved as Treatment by the FDA
Quinidine, also known as Quinidine Gluconate, is approved by the FDA for 4 uses such as Atrial Fibrillation or Flutter and Malaria .Atrial Fibrillation or Flutter
Malaria
Atrial Fibrillation
Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Effectiveness
How Quinidex Affects PatientsQuinidine is a drug used to treat irregular heart rhythms, such as atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia. It can increase the rate of your heartbeat, and may also cause a prolongation of the QT interval. This could lead to a type of dangerous irregular heart rhythm called _torsades de pointes_. You are at greater risk of this if you have a slow heartbeat, low potassium or magnesium levels, or if you have high levels of quinidine in your system. It may also increase the rate of your heartbeat if you have atrial
How Quinidex works in the bodyQuinidine works to treat arrhythmias by blocking sodium channels in the heart muscles. This prevents the rapid depolarization of the heart's action potential. Quinidine also reduces the flow of potassium and calcium in the heart, which lengthens the action potential and increases the chances of early afterdepolarization. Additionally, quinidine is used to treat malaria, as it acts as a parasite killer within red blood cells.
When to interrupt dosage
The measure of Quinidex depends on the determined condition, including Ventricular Arrhythmia, reduce dextromethorphan metabolism and Atrial Fibrillation. The quantity of dosage adapts as per the technique of delivery found in the table beneath.Condition
Dosage
Administration
Ventricular Arrhythmia
, 195.0 mg, 300.0 mg, 10.0 mg, 100.0 mg, 200.0 mg, 80.0 mg/mL, 190.0 mg/mL, 324.0 mg, 325.0 mg, 275.0 mg
Oral, , Capsule, gelatin coated, Solution, Tablet, Liquid - Intramuscular; Intravenous, Intravenous, Tablet, extended release, Liquid, Tablet - Oral, Intramuscular; Intravenous, Capsule, gelatin coated - Oral, Solution - Intramuscular, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Intramuscular, Solution - Intravenous, Tablet, film coated, extended release
reduce dextromethorphan metabolism
, 195.0 mg, 300.0 mg, 10.0 mg, 100.0 mg, 200.0 mg, 80.0 mg/mL, 190.0 mg/mL, 324.0 mg, 325.0 mg, 275.0 mg
Oral, , Capsule, gelatin coated, Solution, Tablet, Liquid - Intramuscular; Intravenous, Intravenous, Tablet, extended release, Liquid, Tablet - Oral, Intramuscular; Intravenous, Capsule, gelatin coated - Oral, Solution - Intramuscular, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Intramuscular, Solution - Intravenous, Tablet, film coated, extended release
Atrial Fibrillation
, 195.0 mg, 300.0 mg, 10.0 mg, 100.0 mg, 200.0 mg, 80.0 mg/mL, 190.0 mg/mL, 324.0 mg, 325.0 mg, 275.0 mg
Oral, , Capsule, gelatin coated, Solution, Tablet, Liquid - Intramuscular; Intravenous, Intravenous, Tablet, extended release, Liquid, Tablet - Oral, Intramuscular; Intravenous, Capsule, gelatin coated - Oral, Solution - Intramuscular, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Intramuscular, Solution - Intravenous, Tablet, film coated, extended release
Atrial Fibrillation or Flutter
, 195.0 mg, 300.0 mg, 10.0 mg, 100.0 mg, 200.0 mg, 80.0 mg/mL, 190.0 mg/mL, 324.0 mg, 325.0 mg, 275.0 mg
Oral, , Capsule, gelatin coated, Solution, Tablet, Liquid - Intramuscular; Intravenous, Intravenous, Tablet, extended release, Liquid, Tablet - Oral, Intramuscular; Intravenous, Capsule, gelatin coated - Oral, Solution - Intramuscular, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Intramuscular, Solution - Intravenous, Tablet, film coated, extended release
Pseudobulbar Affect (PBA)
, 195.0 mg, 300.0 mg, 10.0 mg, 100.0 mg, 200.0 mg, 80.0 mg/mL, 190.0 mg/mL, 324.0 mg, 325.0 mg, 275.0 mg
Oral, , Capsule, gelatin coated, Solution, Tablet, Liquid - Intramuscular; Intravenous, Intravenous, Tablet, extended release, Liquid, Tablet - Oral, Intramuscular; Intravenous, Capsule, gelatin coated - Oral, Solution - Intramuscular, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Intramuscular, Solution - Intravenous, Tablet, film coated, extended release
Malaria
, 195.0 mg, 300.0 mg, 10.0 mg, 100.0 mg, 200.0 mg, 80.0 mg/mL, 190.0 mg/mL, 324.0 mg, 325.0 mg, 275.0 mg
Oral, , Capsule, gelatin coated, Solution, Tablet, Liquid - Intramuscular; Intravenous, Intravenous, Tablet, extended release, Liquid, Tablet - Oral, Intramuscular; Intravenous, Capsule, gelatin coated - Oral, Solution - Intramuscular, Tablet, extended release - Oral, Tablet, film coated, extended release - Oral, Intramuscular, Solution - Intravenous, Tablet, film coated, extended release
Warnings
Quinidex ContraindicationsCondition
Risk Level
Notes
Thrombocytopenic Purpura
Do Not Combine
Myasthenia Gravis
Do Not Combine
Common Quinidex Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Quinidine.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Quinidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Quinidine.
Acepromazine
Major
Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Quinidex Toxicity & Overdose RiskTaking too much quinidine can be very dangerous. In some cases, it has even been fatal. A child once died after taking 5 grams of quinidine, while another person survived after taking 8 grams. Taking too much quinidine can also cause the stomach to form a hard blockage called a bezoar, which can lead to higher levels of the drug in the body. Other signs of quinidine overdose include irregular heartbeats, low blood pressure, vomiting, ringing in the ears, vision problems, headaches, confusion, and delirium.
Quinidex Novel Uses: Which Conditions Have a Clinical Trial Featuring Quinidex?
Currently, five investigations are being conducted to assess the utility of Quinidex in treating Atrial Fibrillation or Flutter, Atrial Fibrillation and Malaria.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation or Flutter
0 Actively Recruiting
Atrial Fibrillation
0 Actively Recruiting
Malaria
1 Actively Recruiting
Phase 1
Ventricular Arrhythmia
4 Actively Recruiting
Not Applicable
Pseudobulbar Affect (PBA)
0 Actively Recruiting
reduce dextromethorphan metabolism
0 Actively Recruiting
Quinidex Reviews: What are patients saying about Quinidex?
5Patient Review
2/23/2009 This treatment has been keeping me alive and well since 1989.
2.3Patient Review
8/31/2011 I experienced severe joint stiffness for six months before learning that my quinidine medications were the root cause. I'm thankful to Dr. Frank C. Arnett of Houston for diagnosing the problem. This is a rare side effect, but it's one that should definitely be noted by patients and doctors alike.
1Patient Review
5/21/2009 I haven't taken it yet, but I was ordered to by my heart doctor today.
Patient Q&A Section about quinidex
What is Quinidex used for?
"Quinidex is a prescription medicine used to treat the symptoms of Arrhythmias, which is an irregularity in the heart's rhythm. Quinidex may be used alone or with other medications. Quinidex belongs to a class of drugs that includes Antidysrhythmics and Antimalarials." - Anonymous Online Contributor
Unverified Answer
What class of drug is procainamide?
"Procainamide is a medication used to treat irregular heartbeats. It is a Class 1A antiarrhythmic agent." - Anonymous Online Contributor
Unverified Answer
What is procainamide given for?
"Procainamide injection is used to treat irregular heartbeats. It works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues." - Anonymous Online Contributor
Unverified Answer
What is the generic name for quinidine?
"The generic name for quinidine is quinidine. It is available in the form of quinidine sulfate tablets and quinidine gluconate extended-release tablets. In the past, quinidine was available under various brand names such as Cardioquin, Cin-Quin, and Quinidex, but these are no longer available." - Anonymous Online Contributor
Unverified Answer