Quinidex

Malaria, Atrial Fibrillation, Ventricular Arrhythmia + 3 more
Treatment
6 FDA approvals
6 Active Studies for Quinidex

What is Quinidex

QuinidineThe Generic name of this drug
Treatment SummaryQuinidine is an alkaloid derived from the bark of the Cinchona tree. It is an optical isomer of quinine. The drug works by blocking sodium and potassium currents in the body, which helps to reduce the excitability of muscles, making them less active. It also blocks certain nerve signals, preventing them from reaching their targets.
Quinidine Gluconateis the brand name
image of different drug pills on a surface
Quinidex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinidine Gluconate
Quinidine
1950
24

Approved as Treatment by the FDA

Quinidine, also known as Quinidine Gluconate, is approved by the FDA for 6 uses such as prophylaxis of atrial flutter/fibrillation and Malaria caused by Plasmodium falciparum .
prophylaxis of atrial flutter/fibrillation
Malaria caused by Plasmodium falciparum
Malaria
Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Atrial Fibrillation
Atrial Fibrillation or Flutter

Effectiveness

How Quinidex Affects PatientsQuinidine is a drug used to treat irregular heart rhythms, such as atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia. It can increase the rate of your heartbeat, and may also cause a prolongation of the QT interval. This could lead to a type of dangerous irregular heart rhythm called _torsades de pointes_. You are at greater risk of this if you have a slow heartbeat, low potassium or magnesium levels, or if you have high levels of quinidine in your system. It may also increase the rate of your heartbeat if you have atrial
How Quinidex works in the bodyQuinidine works to treat arrhythmias by blocking sodium channels in the heart muscles. This prevents the rapid depolarization of the heart's action potential. Quinidine also reduces the flow of potassium and calcium in the heart, which lengthens the action potential and increases the chances of early afterdepolarization. Additionally, quinidine is used to treat malaria, as it acts as a parasite killer within red blood cells.

When to interrupt dosage

The measure of Quinidex depends on the determined condition, including Ventricular Arrhythmia, reduce dextromethorphan metabolism and Atrial Fibrillation. The quantity of dosage adapts as per the technique of delivery found in the table beneath.
Condition
Dosage
Administration
Malaria
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Atrial Fibrillation or Flutter
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
reduce dextromethorphan metabolism
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Atrial Fibrillation
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Ventricular Arrhythmia
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Pseudobulbar Affect (PBA)
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous

Warnings

Quinidex Contraindications
Condition
Risk Level
Notes
Purpura, Thrombocytopenic
Do Not Combine
Myasthenia Gravis
Do Not Combine
There are 20 known major drug interactions with Quinidex.
Common Quinidex Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Quinidine.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Quinidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Quinidine.
Acepromazine
Major
Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Quinidex Toxicity & Overdose RiskTaking too much quinidine can be very dangerous. In some cases, it has even been fatal. A child once died after taking 5 grams of quinidine, while another person survived after taking 8 grams. Taking too much quinidine can also cause the stomach to form a hard blockage called a bezoar, which can lead to higher levels of the drug in the body. Other signs of quinidine overdose include irregular heartbeats, low blood pressure, vomiting, ringing in the ears, vision problems, headaches, confusion, and delirium.
image of a doctor in a lab doing drug, clinical research

Quinidex Novel Uses: Which Conditions Have a Clinical Trial Featuring Quinidex?

Currently, five investigations are being conducted to assess the utility of Quinidex in treating Atrial Fibrillation or Flutter, Atrial Fibrillation and Malaria.
Condition
Clinical Trials
Trial Phases
Ventricular Arrhythmia
5 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Atrial Fibrillation
0 Actively Recruiting
Pseudobulbar Affect (PBA)
0 Actively Recruiting
Atrial Fibrillation or Flutter
1 Actively Recruiting
Not Applicable
reduce dextromethorphan metabolism
0 Actively Recruiting
Malaria
0 Actively Recruiting

Quinidex Reviews: What are patients saying about Quinidex?

5Patient Review
2/23/2009
Quinidex for Sudden Rapid Heartbeat-Paroxysmal Ventricular Tachycardia
This treatment has been keeping me alive and well since 1989.
2.3Patient Review
8/31/2011
Quinidex for Heart Ventricle Rhythm Problem
I experienced severe joint stiffness for six months before learning that my quinidine medications were the root cause. I'm thankful to Dr. Frank C. Arnett of Houston for diagnosing the problem. This is a rare side effect, but it's one that should definitely be noted by patients and doctors alike.
1Patient Review
5/21/2009
Quinidex for Atrial Fibrillation
I haven't taken it yet, but I was ordered to by my heart doctor today.
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Patient Q&A Section about quinidex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Quinidex used for?

"Quinidex is a prescription medicine used to treat the symptoms of Arrhythmias, which is an irregularity in the heart's rhythm. Quinidex may be used alone or with other medications. Quinidex belongs to a class of drugs that includes Antidysrhythmics and Antimalarials."

Answered by AI

What class of drug is procainamide?

"Procainamide is a medication used to treat irregular heartbeats. It is a Class 1A antiarrhythmic agent."

Answered by AI

What is procainamide given for?

"Procainamide injection is used to treat irregular heartbeats. It works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues."

Answered by AI

What is the generic name for quinidine?

"The generic name for quinidine is quinidine. It is available in the form of quinidine sulfate tablets and quinidine gluconate extended-release tablets. In the past, quinidine was available under various brand names such as Cardioquin, Cin-Quin, and Quinidex, but these are no longer available."

Answered by AI

Clinical Trials for Quinidex

Have you considered Quinidex clinical trials? We made a collection of clinical trials featuring Quinidex, we think they might fit your search criteria.
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