Quinidex

Malaria, Atrial Fibrillation, Ventricular Arrhythmia + 3 more
Treatment
6 FDA approvals
7 Active Studies for Quinidex

What is Quinidex

QuinidineThe Generic name of this drug
Treatment SummaryQuinidine is an alkaloid derived from the bark of the Cinchona tree. It is an optical isomer of quinine. The drug works by blocking sodium and potassium currents in the body, which helps to reduce the excitability of muscles, making them less active. It also blocks certain nerve signals, preventing them from reaching their targets.
Quinidine Gluconateis the brand name
image of different drug pills on a surface
Quinidex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinidine Gluconate
Quinidine
1950
24

Approved as Treatment by the FDA

Quinidine, also known as Quinidine Gluconate, is approved by the FDA for 6 uses such as prophylaxis of atrial flutter/fibrillation and Malaria caused by Plasmodium falciparum .
prophylaxis of atrial flutter/fibrillation
Malaria caused by Plasmodium falciparum
Malaria
Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Atrial Fibrillation
Atrial Fibrillation or Flutter

Effectiveness

How Quinidex Affects PatientsQuinidine is a drug used to treat irregular heart rhythms, such as atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia. It can increase the rate of your heartbeat, and may also cause a prolongation of the QT interval. This could lead to a type of dangerous irregular heart rhythm called _torsades de pointes_. You are at greater risk of this if you have a slow heartbeat, low potassium or magnesium levels, or if you have high levels of quinidine in your system. It may also increase the rate of your heartbeat if you have atrial
How Quinidex works in the bodyQuinidine works to treat arrhythmias by blocking sodium channels in the heart muscles. This prevents the rapid depolarization of the heart's action potential. Quinidine also reduces the flow of potassium and calcium in the heart, which lengthens the action potential and increases the chances of early afterdepolarization. Additionally, quinidine is used to treat malaria, as it acts as a parasite killer within red blood cells.

When to interrupt dosage

The measure of Quinidex depends on the determined condition, including Ventricular Arrhythmia, reduce dextromethorphan metabolism and Atrial Fibrillation. The quantity of dosage adapts as per the technique of delivery found in the table beneath.
Condition
Dosage
Administration
Malaria
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Atrial Fibrillation or Flutter
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
reduce dextromethorphan metabolism
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Atrial Fibrillation
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Ventricular Arrhythmia
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Pseudobulbar Affect (PBA)
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous

Warnings

Quinidex Contraindications
Condition
Risk Level
Notes
Purpura, Thrombocytopenic
Do Not Combine
Myasthenia Gravis
Do Not Combine
There are 20 known major drug interactions with Quinidex.
Common Quinidex Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Quinidine.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Quinidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Quinidine.
Acepromazine
Major
Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Quinidex Toxicity & Overdose RiskTaking too much quinidine can be very dangerous. In some cases, it has even been fatal. A child once died after taking 5 grams of quinidine, while another person survived after taking 8 grams. Taking too much quinidine can also cause the stomach to form a hard blockage called a bezoar, which can lead to higher levels of the drug in the body. Other signs of quinidine overdose include irregular heartbeats, low blood pressure, vomiting, ringing in the ears, vision problems, headaches, confusion, and delirium.
image of a doctor in a lab doing drug, clinical research

Quinidex Novel Uses: Which Conditions Have a Clinical Trial Featuring Quinidex?

Currently, five investigations are being conducted to assess the utility of Quinidex in treating Atrial Fibrillation or Flutter, Atrial Fibrillation and Malaria.
Condition
Clinical Trials
Trial Phases
Ventricular Arrhythmia
7 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Atrial Fibrillation
0 Actively Recruiting
Pseudobulbar Affect (PBA)
0 Actively Recruiting
Atrial Fibrillation or Flutter
0 Actively Recruiting
reduce dextromethorphan metabolism
0 Actively Recruiting
Malaria
0 Actively Recruiting

Quinidex Reviews: What are patients saying about Quinidex?

5Patient Review
2/23/2009
Quinidex for Sudden Rapid Heartbeat-Paroxysmal Ventricular Tachycardia
This treatment has been keeping me alive and well since 1989.
2.3Patient Review
8/31/2011
Quinidex for Heart Ventricle Rhythm Problem
I experienced severe joint stiffness for six months before learning that my quinidine medications were the root cause. I'm thankful to Dr. Frank C. Arnett of Houston for diagnosing the problem. This is a rare side effect, but it's one that should definitely be noted by patients and doctors alike.
1Patient Review
5/21/2009
Quinidex for Atrial Fibrillation
I haven't taken it yet, but I was ordered to by my heart doctor today.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about quinidex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Quinidex used for?

"Quinidex is a prescription medicine used to treat the symptoms of Arrhythmias, which is an irregularity in the heart's rhythm. Quinidex may be used alone or with other medications. Quinidex belongs to a class of drugs that includes Antidysrhythmics and Antimalarials."

Answered by AI

What class of drug is procainamide?

"Procainamide is a medication used to treat irregular heartbeats. It is a Class 1A antiarrhythmic agent."

Answered by AI

What is procainamide given for?

"Procainamide injection is used to treat irregular heartbeats. It works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues."

Answered by AI

What is the generic name for quinidine?

"The generic name for quinidine is quinidine. It is available in the form of quinidine sulfate tablets and quinidine gluconate extended-release tablets. In the past, quinidine was available under various brand names such as Cardioquin, Cin-Quin, and Quinidex, but these are no longer available."

Answered by AI

Clinical Trials for Quinidex

Image of Emory University Hospital in Atlanta, United States.

EDEN System for Ventricular Arrhythmia

21 - 100
All Sexes
Atlanta, GA
Background: Heart surgeons use electrocardiogram (ECG) machines to record electrical signals from the heart during procedures. Normal ECG machines connect only to the skin. Special ECG machines connect directly to the heart; they are a safer option during procedures. Researchers want to test a new ECG machine called the EDEN system. Objective: To test the EDEN system in people having heart procedures. The new system will be used along with an approved special ECG machine. Eligibility: People aged 21 years or older who need to have a heart procedure. These procedures can include (1) electrophysiology mapping or ablation; and (2) conduction system pacing. Design: Researchers will review participants' medical records. No extra tests are needed. Participants will have their heart procedure as planned. The EDEN system will be linked to the special ECG used during the procedure. An extra electrode may be placed on the participant's body. Electrodes are small stickers attached to wires that go to the machine. The EDEN system will record and analyze electrical signals already being measured. It will not interfere with participants' care. No medical decisions well be made based on its data. No follow-up visits are needed for this study....
Waitlist Available
Has No Placebo
Emory University HospitalRobert J Lederman, M.D.
Image of Keck Hospital of the University of Southern California in Los Angeles, United States.

Mitral Valve Repair Procedures for Mitral Valve Prolapse

18+
All Sexes
Los Angeles, CA
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological processes by which mitral valve prolapse (MVP) can impact left ventricular (LV) myocardial structure and function, and, thereby, predispose to arrhythmias and sudden death. Such insights are key to identifying interventions to reduce the long-term sequelae of heart failure (HF) and arrhythmias, as well as delineate optimal therapeutic approaches for different patient sub-groups.
Recruiting
Has No Placebo
Keck Hospital of the University of Southern California (+15 Sites)Martin Leon, MD
Image of HonorHealth in Scottsdale, United States.

Carvedilol vs Metoprolol for Heart Failure

18+
All Sexes
Scottsdale, AZ
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter defibrillator (ICD). The study will enroll 2,000 participants across 100 U.S. sites and includes an 18-month feasibility phase with 100 participants from 15 sites. Eligible participants must be currently treated with metoprolol succinate and willing to switch to carvedilol, with randomization in a 1:1 ratio. Participants will be followed for up to 3 years, with regular assessments including ICD interrogations, medication adherence, healthcare utilization, and quality of life surveys. The primary endpoint is the first occurrence of any ICD therapy (appropriate or inappropriate), cardiovascular (CV) hospitalization, or CV death. Secondary endpoints include ICD shock burden, healthcare utilization, and patient-reported quality of life. The trial aims to provide high-quality comparative data to address clinical equipoise surrounding the two commonly used beta-blockers in HFrEF management.
Phase 4
Recruiting
HonorHealth (+12 Sites)
Image of Emory University in Atlanta, United States.

VINTAGE Procedure for Ventricular Arrhythmia

21 - 100
All Sexes
Atlanta, GA
Background: Ventricular arrhythmia is an abnormal pulse rhythm that starts in the lower part of the heart (ventricles). Treatment includes ablation; ablation uses heat to destroy small portions of the heart that are causing short circuits in the normal heartbeats. But ablation does not always work well because some parts of the heart are hard to reach with current tools. Researchers want to try a new method called VINTAGE (ventricular intramyocardial navigation for tachycardia ablation guided by electrograms). VINTAGE may be better able to treat portions of the heart that are harder to reach with standard techniques. Objective: To test VINTAGE in people with ventricular arrhythmia. Eligibility: People aged 21 years and older with ventricular arrhythmia that did not respond to standard treatment. Design: Participants will have baseline tests. They will have blood tests and tests of their heart function. They will have imaging scans. They will complete a health questionnaire. Participants will undergo the VINTAGE procedure. They will be either completely or partially asleep. Doctors will insert tubes through large blood vessels in the groin. Tubes may also be inserted through the chest and wrist. They will use x-rays and ultrasound to guide tubes and guidewires directly into the heart muscle to do the ablation. Participants will stay in the hospital 1 or more nights after the procedure. Participants will have 3 follow-up visits over 6 months. These visits are for standard care after heart ablation. They will include blood tests, imaging scans, and tests of heart function. Participants may also wear a device to monitor their heart rhythms at home.
Waitlist Available
Has No Placebo
Emory UniversityRobert J Lederman, M.D.
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