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What is Quinidine Sulfate
QuinidineThe Generic name of this drug
Treatment SummaryQuinidine is a medication derived from the bark of the Cinchona tree. It works by blocking the flow of sodium and potassium in and out of cells, which reduces muscle contractions. It also blocks certain types of neurotransmitters to reduce the transmission of signals between nerves. Quinidine is used to treat irregular heartbeats (arrhythmia) and other heart conditions.
Quinidine Gluconateis the brand name
Quinidine Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinidine Gluconate
Quinidine
1950
24
Approved as Treatment by the FDA
Quinidine, also known as Quinidine Gluconate, is approved by the FDA for 4 uses such as Ventricular Arrhythmia and Atrial Fibrillation .Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Atrial Fibrillation
Atrial Fibrillation or Flutter
Malaria
Effectiveness
How Quinidine Sulfate Affects PatientsQuinidine is a medication used to treat certain heart rhythm problems like atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia. In most cases it increases the heart rate and can also cause a prolonged QT interval which can lead to a type of irregular heartbeat called torsades de pointes. The risk of this side effect is higher when the patient is taking other drugs that slow the heart rate, has low potassium or magnesium levels, or high levels of quinidine in their blood. Patients with sick sinus syndrome may also experience lowered heart rate and bradycardia while
How Quinidine Sulfate works in the bodyQuinidine helps to regulate heart rhythm by working on sodium and potassium channels in the heart. It reduces the flow of these channels, which leads to an extended action potential and slower heart rate. It also works as an anti-malarial drug, helping to kill the parasites in your body that cause the disease.
When to interrupt dosage
The quantity of Quinidine Sulfate is contingent upon the diagnosed affliction, including Ventricular Arrhythmia, decrease dextromethorphan metabolism and Atrial Fibrillation. The measure of dosage varies, as per the technique of delivery specified in the table beneath.Condition
Dosage
Administration
Atrial Fibrillation or Flutter
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
reduce dextromethorphan metabolism
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Pseudobulbar Affect (PBA)
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Ventricular Arrhythmia
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Atrial Fibrillation
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Malaria
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Warnings
Quinidine Sulfate ContraindicationsCondition
Risk Level
Notes
Thrombocytopenic Purpura
Do Not Combine
Myasthenia Gravis
Do Not Combine
Common Quinidine Sulfate Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Quinidine.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Quinidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Quinidine.
Acepromazine
Major
Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Quinidine Sulfate Toxicity & Overdose RiskOverdosing on quinidine can be fatal, as demonstrated by a toddler who died after ingesting 5 grams of the drug. A 16-month old child was also reported to have developed a bezoar in the stomach after ingesting quinidine tablets. In cases of large overdoses, endoscopy may be necessary. Symptoms of acute quinidine overdose can include irregular heartbeat, low blood pressure, vomiting, hearing loss, dizziness, blurred vision, double vision, sensitivity to light, headaches, confusion, and delirium.
Quinidine Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Quinidine Sulfate?
Five active studies are assessing the utility of Quinidine Sulfate in treating Atrial Fibrillation or Flutter, Atrial Fibrillation and Malaria.Condition
Clinical Trials
Trial Phases
reduce dextromethorphan metabolism
0 Actively Recruiting
Pseudobulbar Affect (PBA)
0 Actively Recruiting
Malaria
0 Actively Recruiting
Atrial Fibrillation
0 Actively Recruiting
Atrial Fibrillation or Flutter
1 Actively Recruiting
Not Applicable
Ventricular Arrhythmia
2 Actively Recruiting
Not Applicable
Quinidine Sulfate Reviews: What are patients saying about Quinidine Sulfate?
5Patient Review
6/23/2010 I'm a senior runner, and I have never taken drugs in my life. However, after being locked in a fib for six weeks, I decided to give this medication a try. Eight months later, I haven't had any problems.
5Patient Review
11/9/20075Patient Review
3/16/2013 This medication is excellent for the occasional bout of A-fib caused by alcohol. The only downside is that it always gives me diarrhea.
4.3Patient Review
1/15/2010 I take a 300 mg tablet twice a day, morning and evening. I have had no atrial fibrillation issues since I started taking the medicine.
3Patient Review
7/3/2014 I took Quinidine Sulfate ER 300 mg for 20 years with no problems..Last Nov. my prescription drug co. could no longer supply it. I was put on Betapace. Went into a-fib 1 week later. Doseage was increased. Three months later-a-fib again. Was put on Cordorone. Couldn't tolerate it so it was stopped. I'm waiting for it to clear my body. My current prescription company can supply Quinidine.
Patient Q&A Section about quinidine sulfate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is quinidine sulfate used for?
"Quinidine is a medication used to treat certain types of irregular heartbeats by making the heart more resistant to abnormal activity."
Answered by AI
Is quinidine sulfate still available?
"It is available as quinidine sulfate tablets and quinidine gluconate extended-release tablets. Quinidine was previously available under various brand names such as Cardioquin, Cin-Quin, and Quinidex, but those versions are no longer available. Currently, quinidine is only available as a generic form."
Answered by AI
Is quinidine a sulfa drug?
"Quinidine Sulfate is a prescription medicine used to treat the symptoms of Arrhythmias. It may be used alone or with other medications. Quinidine Sulfate belongs to a class of drugs called [drug class]. It is not known if Quinidine Sulfate is safe and effective in children."
Answered by AI
Does quinidine increase heart rate?
"Quinidine caused an increase in heart rate both when a person was at rest and when they were exercising lightly. There was no significant effect on systolic blood pressure in response to any level of activity."
Answered by AI