Quinidine Sulfate

Malaria, Atrial Fibrillation, Ventricular Arrhythmia + 3 more
Treatment
6 FDA approvals
7 Active Studies for Quinidine Sulfate

What is Quinidine Sulfate

QuinidineThe Generic name of this drug
Treatment SummaryQuinidine is a medication derived from the bark of the Cinchona tree. It works by blocking the flow of sodium and potassium in and out of cells, which reduces muscle contractions. It also blocks certain types of neurotransmitters to reduce the transmission of signals between nerves. Quinidine is used to treat irregular heartbeats (arrhythmia) and other heart conditions.
Quinidine Gluconateis the brand name
image of different drug pills on a surface
Quinidine Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinidine Gluconate
Quinidine
1950
24

Approved as Treatment by the FDA

Quinidine, also known as Quinidine Gluconate, is approved by the FDA for 6 uses such as prophylaxis of atrial flutter/fibrillation and Malaria caused by Plasmodium falciparum .
prophylaxis of atrial flutter/fibrillation
Malaria caused by Plasmodium falciparum
Malaria
Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Atrial Fibrillation
Atrial Fibrillation or Flutter

Effectiveness

How Quinidine Sulfate Affects PatientsQuinidine is a medication used to treat certain heart rhythm problems like atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia. In most cases it increases the heart rate and can also cause a prolonged QT interval which can lead to a type of irregular heartbeat called torsades de pointes. The risk of this side effect is higher when the patient is taking other drugs that slow the heart rate, has low potassium or magnesium levels, or high levels of quinidine in their blood. Patients with sick sinus syndrome may also experience lowered heart rate and bradycardia while
How Quinidine Sulfate works in the bodyQuinidine helps to regulate heart rhythm by working on sodium and potassium channels in the heart. It reduces the flow of these channels, which leads to an extended action potential and slower heart rate. It also works as an anti-malarial drug, helping to kill the parasites in your body that cause the disease.

When to interrupt dosage

The quantity of Quinidine Sulfate is contingent upon the diagnosed affliction, including Ventricular Arrhythmia, decrease dextromethorphan metabolism and Atrial Fibrillation. The measure of dosage varies, as per the technique of delivery specified in the table beneath.
Condition
Dosage
Administration
Malaria
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Intramuscular, Solution - Intramuscular, Solution, Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Tablet, extended release - Oral, Tablet, film coated, extended release, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Solution - Intravenous, Intravenous, Tablet, film coated, extended release - Oral
Atrial Fibrillation or Flutter
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Intramuscular, Solution - Intramuscular, Solution, Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Tablet, extended release - Oral, Tablet, film coated, extended release, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Solution - Intravenous, Intravenous, Tablet, film coated, extended release - Oral
reduce dextromethorphan metabolism
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Intramuscular, Solution - Intramuscular, Solution, Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Tablet, extended release - Oral, Tablet, film coated, extended release, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Solution - Intravenous, Intravenous, Tablet, film coated, extended release - Oral
Atrial Fibrillation
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Intramuscular, Solution - Intramuscular, Solution, Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Tablet, extended release - Oral, Tablet, film coated, extended release, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Solution - Intravenous, Intravenous, Tablet, film coated, extended release - Oral
Ventricular Arrhythmia
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Intramuscular, Solution - Intramuscular, Solution, Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Tablet, extended release - Oral, Tablet, film coated, extended release, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Solution - Intravenous, Intravenous, Tablet, film coated, extended release - Oral
Pseudobulbar Affect (PBA)
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Intramuscular, Solution - Intramuscular, Solution, Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Tablet, extended release - Oral, Tablet, film coated, extended release, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Solution - Intravenous, Intravenous, Tablet, film coated, extended release - Oral

Warnings

Quinidine Sulfate Contraindications
Condition
Risk Level
Notes
Purpura, Thrombocytopenic
Do Not Combine
Myasthenia Gravis
Do Not Combine
There are 20 known major drug interactions with Quinidine Sulfate.
Common Quinidine Sulfate Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Quinidine.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Quinidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Quinidine.
Acepromazine
Major
Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Quinidine Sulfate Toxicity & Overdose RiskOverdosing on quinidine can be fatal, as demonstrated by a toddler who died after ingesting 5 grams of the drug. A 16-month old child was also reported to have developed a bezoar in the stomach after ingesting quinidine tablets. In cases of large overdoses, endoscopy may be necessary. Symptoms of acute quinidine overdose can include irregular heartbeat, low blood pressure, vomiting, hearing loss, dizziness, blurred vision, double vision, sensitivity to light, headaches, confusion, and delirium.

Quinidine Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Quinidine Sulfate?

Five active studies are assessing the utility of Quinidine Sulfate in treating Atrial Fibrillation or Flutter, Atrial Fibrillation and Malaria.
Condition
Clinical Trials
Trial Phases
Ventricular Arrhythmia
7 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Atrial Fibrillation
0 Actively Recruiting
Pseudobulbar Affect (PBA)
0 Actively Recruiting
Atrial Fibrillation or Flutter
0 Actively Recruiting
reduce dextromethorphan metabolism
0 Actively Recruiting
Malaria
0 Actively Recruiting

Quinidine Sulfate Reviews: What are patients saying about Quinidine Sulfate?

5Patient Review
6/23/2010
Quinidine Sulfate for Sudden Rapid Heartbeat-Paroxysmal Ventricular Tachycardia
I'm a senior runner, and I have never taken drugs in my life. However, after being locked in a fib for six weeks, I decided to give this medication a try. Eight months later, I haven't had any problems.
5Patient Review
11/9/2007
Quinidine Sulfate for Atrial Fibrillation
5Patient Review
3/16/2013
Quinidine Sulfate for Atrial Fibrillation
This medication is excellent for the occasional bout of A-fib caused by alcohol. The only downside is that it always gives me diarrhea.
4.3Patient Review
1/15/2010
Quinidine Sulfate for Atrial Fibrillation
I take a 300 mg tablet twice a day, morning and evening. I have had no atrial fibrillation issues since I started taking the medicine.
3Patient Review
7/3/2014
Quinidine Sulfate for Sudden Rapid Heartbeat-Paroxysmal Ventricular Tachycardia
I took Quinidine Sulfate ER 300 mg for 20 years with no problems..Last Nov. my prescription drug co. could no longer supply it. I was put on Betapace. Went into a-fib 1 week later. Doseage was increased. Three months later-a-fib again. Was put on Cordorone. Couldn't tolerate it so it was stopped. I'm waiting for it to clear my body. My current prescription company can supply Quinidine.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about quinidine sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is quinidine sulfate used for?

"Quinidine is a medication used to treat certain types of irregular heartbeats by making the heart more resistant to abnormal activity."

Answered by AI

Is quinidine sulfate still available?

"It is available as quinidine sulfate tablets and quinidine gluconate extended-release tablets. Quinidine was previously available under various brand names such as Cardioquin, Cin-Quin, and Quinidex, but those versions are no longer available. Currently, quinidine is only available as a generic form."

Answered by AI

Is quinidine a sulfa drug?

"Quinidine Sulfate is a prescription medicine used to treat the symptoms of Arrhythmias. It may be used alone or with other medications. Quinidine Sulfate belongs to a class of drugs called [drug class]. It is not known if Quinidine Sulfate is safe and effective in children."

Answered by AI

Does quinidine increase heart rate?

"Quinidine caused an increase in heart rate both when a person was at rest and when they were exercising lightly. There was no significant effect on systolic blood pressure in response to any level of activity."

Answered by AI

Clinical Trials for Quinidine Sulfate

Image of Emory University Hospital in Atlanta, United States.

EDEN System for Ventricular Arrhythmia

21 - 100
All Sexes
Atlanta, GA
Background: Heart surgeons use electrocardiogram (ECG) machines to record electrical signals from the heart during procedures. Normal ECG machines connect only to the skin. Special ECG machines connect directly to the heart; they are a safer option during procedures. Researchers want to test a new ECG machine called the EDEN system. Objective: To test the EDEN system in people having heart procedures. The new system will be used along with an approved special ECG machine. Eligibility: People aged 21 years or older who need to have a heart procedure. These procedures can include (1) electrophysiology mapping or ablation; and (2) conduction system pacing. Design: Researchers will review participants' medical records. No extra tests are needed. Participants will have their heart procedure as planned. The EDEN system will be linked to the special ECG used during the procedure. An extra electrode may be placed on the participant's body. Electrodes are small stickers attached to wires that go to the machine. The EDEN system will record and analyze electrical signals already being measured. It will not interfere with participants' care. No medical decisions well be made based on its data. No follow-up visits are needed for this study....
Waitlist Available
Has No Placebo
Emory University HospitalRobert J Lederman, M.D.
Image of Keck Hospital of the University of Southern California in Los Angeles, United States.

Mitral Valve Repair Procedures for Mitral Valve Prolapse

18+
All Sexes
Los Angeles, CA
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological processes by which mitral valve prolapse (MVP) can impact left ventricular (LV) myocardial structure and function, and, thereby, predispose to arrhythmias and sudden death. Such insights are key to identifying interventions to reduce the long-term sequelae of heart failure (HF) and arrhythmias, as well as delineate optimal therapeutic approaches for different patient sub-groups.
Recruiting
Has No Placebo
Keck Hospital of the University of Southern California (+15 Sites)Joanna Chikwe, MD
Image of HonorHealth in Scottsdale, United States.

Carvedilol vs Metoprolol for Heart Failure

18+
All Sexes
Scottsdale, AZ
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter defibrillator (ICD). The study will enroll 2,000 participants across 100 U.S. sites and includes an 18-month feasibility phase with 100 participants from 15 sites. Eligible participants must be currently treated with metoprolol succinate and willing to switch to carvedilol, with randomization in a 1:1 ratio. Participants will be followed for up to 3 years, with regular assessments including ICD interrogations, medication adherence, healthcare utilization, and quality of life surveys. The primary endpoint is the first occurrence of any ICD therapy (appropriate or inappropriate), cardiovascular (CV) hospitalization, or CV death. Secondary endpoints include ICD shock burden, healthcare utilization, and patient-reported quality of life. The trial aims to provide high-quality comparative data to address clinical equipoise surrounding the two commonly used beta-blockers in HFrEF management.
Phase 4
Recruiting
HonorHealth (+12 Sites)
Image of Emory University in Atlanta, United States.

VINTAGE Procedure for Ventricular Arrhythmia

21 - 100
All Sexes
Atlanta, GA
Background: Ventricular arrhythmia is an abnormal pulse rhythm that starts in the lower part of the heart (ventricles). Treatment includes ablation; ablation uses heat to destroy small portions of the heart that are causing short circuits in the normal heartbeats. But ablation does not always work well because some parts of the heart are hard to reach with current tools. Researchers want to try a new method called VINTAGE (ventricular intramyocardial navigation for tachycardia ablation guided by electrograms). VINTAGE may be better able to treat portions of the heart that are harder to reach with standard techniques. Objective: To test VINTAGE in people with ventricular arrhythmia. Eligibility: People aged 21 years and older with ventricular arrhythmia that did not respond to standard treatment. Design: Participants will have baseline tests. They will have blood tests and tests of their heart function. They will have imaging scans. They will complete a health questionnaire. Participants will undergo the VINTAGE procedure. They will be either completely or partially asleep. Doctors will insert tubes through large blood vessels in the groin. Tubes may also be inserted through the chest and wrist. They will use x-rays and ultrasound to guide tubes and guidewires directly into the heart muscle to do the ablation. Participants will stay in the hospital 1 or more nights after the procedure. Participants will have 3 follow-up visits over 6 months. These visits are for standard care after heart ablation. They will include blood tests, imaging scans, and tests of heart function. Participants may also wear a device to monitor their heart rhythms at home.
Waitlist Available
Has No Placebo
Emory UniversityRobert J Lederman, M.D.
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