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Regular Exercise for Aging Brain Health (BIM Trial)

N/A

Recruiting

Led By Marc J Poulin, PhD, DPhil

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Ability to walk independently outside or on stairs

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured at baseline (0 and 6 months), during the exercise intervention (9 months), exercise intervention completion (12 months) and follow up (18,72 and 132 months)

Awards & highlights

BIM Trial Summary

This trial is designed to study the effects of physical activity on the brain. It will test if exercise can help maintain brain function as we age.

Who is the study for?

This trial is for men and women aged 55 or older who are generally inactive, with a BMI under 35, can walk independently, and have not had major surgery or trauma in the past 6 months. Women must be postmenopausal for at least a year. People with recent heart issues, stroke, chronic headaches, blood clots, smokers within the last year or those on certain medications like beta-blockers cannot participate.Check my eligibility

What is being tested?

The study tests if regular aerobic exercise improves brain blood flow (cerebrovascular reserve) and mental functions in older adults. It includes an initial assessment period followed by six months of guided aerobic training based on established guidelines and cognitive testing before concluding with follow-up assessments over several years.See study design

What are the potential side effects?

Aerobic exercise is typically safe but may include muscle soreness, fatigue, falls risk for those with balance issues; however serious side effects are rare especially when activities are tailored to individual fitness levels as per this study's design.

BIM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can walk by myself outside or on stairs.

BIM Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured at baseline (0 and 6 months), during the exercise intervention (9 months), exercise intervention completion (12 months) and follow up (18,72 and 132 months)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured at baseline (0 and 6 months), during the exercise intervention (9 months), exercise intervention completion (12 months) and follow up (18,72 and 132 months)

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at baseline (0 and 6 months), during the exercise intervention (9 months), exercise intervention completion (12 months) and follow up (18,72 and 132 months) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Cognition Assessed by Neuropsychological Test Battery

Secondary outcome measures

Change in Blood Biomarkers Assessed by Elisa Assays

Change in Cerebral Blood Flow Assessed by Transcranial Doppler Ultrasound

Change in Maximal Oxygen Uptake (VO2max) Assessed by Metabolic Cart

+1 more

Other outcome measures

Change in Brain Structure and Function Assessed by Neuroimaging Modalities

Change in Sleep Quality Assessed by Polysomnography, Actigraphy and Questionnaires

BIM Trial Design

1Treatment groups

Experimental Treatment

Group I: Aerobic exerciseExperimental Treatment1 Intervention

Participants took part in a supervised 6-month long aerobic (walk/jog) training program held 3 days/week. Each session included a 5-min warm-up, 20-40 min of aerobic exercise (walking, jogging), 5-min cool-down, and stretching. Exercise prescriptions follow current principles and guidelines established by ACSM/AHA, including sufficient warm-up, cooldown, and ongoing provision of safety precautions/exercise tips. As participants progress, the duration of aerobic exercise increased from 20 (month 1) to 30 (months 2-3) and 40 min (months 4-6), with proportional increases to warm-up and cool-down periods. Exercise intensity is based on individual maximal oxygen uptake (VO2 max), measured at baseline. Intensity builds from 30-45% (months 1-3) to mitigate the risk of injury and will progress to 60-70% (months 4-6) heart rate reserve (HRR).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aerobic exercise

2000

Completed Phase 2

~1130

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor

792 Previous Clinical Trials

868,868 Total Patients Enrolled

3 Trials studying Aging

365 Patients Enrolled for Aging

Canadian Institutes of Health Research (CIHR)OTHER_GOV

1,345 Previous Clinical Trials

26,453,481 Total Patients Enrolled

14 Trials studying Aging

4,306 Patients Enrolled for Aging

Marc J Poulin, PhD, DPhilPrincipal InvestigatorUniversity of Calgary

3 Previous Clinical Trials

300 Total Patients Enrolled

Media Library

Aerobic exercise Clinical Trial Eligibility Overview. Trial Name: NCT03158337 — N/A

Aging Research Study Groups: Aerobic exercise

Aging Clinical Trial 2023: Aerobic exercise Highlights & Side Effects. Trial Name: NCT03158337 — N/A

Aerobic exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT03158337 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are being administered care in this experiment?

"Affirmative. Clinicaltrials.gov's records show that this research study is still recruiting patients, with the original posting dating back to May 1st 2010 and its latest update taking place on November 2nd 2022. The trial requires 286 participants from a single location for completion."

Answered by AI

Are there vacancies available to participate in this research experiment?

"Yes, according to the information available on clinicaltrials.gov, this medical trial is currently recruiting participants. It was originally posted in May of 2010 and has been recently updated in November 2022; they require 286 subject across a single site."

Answered by AI

Recent research and studies

BMC GeriatricsJournal

The Brain-in-motion Study: Effect of a 6-month Aerobic Exercise Intervention on Cerebrovascular Regulation and Cognitive Function in Older Adults

Tyndall, Amanda V, Margie H Davenport, Ben J Wilson, Grazyna M Burek, Genevieve Arsenault-Lapierre, Eryka Haley, Gail A Eskes, et al.. 2013. “The Brain-in-motion Study: Effect of a 6-month Aerobic Exercise Intervention on Cerebrovascular Regulation and Cognitive Function in Older Adults”. BMC Geriatrics. Springer Science and Business Media LLC. doi:10.1186/1471-2318-13-21.

apoeJournal

Evidence of Association Between Sleep Quality and <i>apoe</i> Ε4 in Healthy Older Adults

Drogos, Lauren L., Stephanie J. Gill, Amanda V. Tyndall, Jill K. Raneri, Jillian S. Parboosingh, Aileen Naef, Kyle D. Guild, Gail Eskes, Patrick J. Hanly, and Marc J. Poulin. 2016. “Evidence of Association Between Sleep Quality and apoe Ε4 in Healthy Older Adults”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/wnl.0000000000003255.

BMC Complementary and Alternative MedicineJournal

Medication Use by Middle-aged and Older Participants of an Exercise Study: Results from the Brain in Motion Study

Pannu, Tania, Sarah Sharkey, Grazyna Burek, Daniela Cretu, Michael D. Hill, David B. Hogan, and Marc J. Poulin. 2017. “Medication Use by Middle-aged and Older Participants of an Exercise Study: Results from the Brain in Motion Study”. BMC Complementary and Alternative Medicine. Springer Science and Business Media LLC. doi:10.1186/s12906-017-1595-5.

Experimental Brain ResearchJournal