Autologous Stem Cell Infusion for Neuroblastoma

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
NeuroblastomaAutologous Stem Cell Infusion - Biological
Eligibility
< 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing a new treatment for neuroblastoma that involves two courses of chemotherapy followed by stem cell rescue.

Treatment Effectiveness

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 3 years from first PBSC infusion

Year 3
Overall Survival
Progression Free Survival
Relapse
Day 42
Time to Engraftment

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Patients Treated for Neuroblastoma
1 of 1

Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: Autologous Stem Cell Infusion · No Placebo Group · Phase 2

Patients Treated for NeuroblastomaExperimental Group · 7 Interventions: Thiotepa, Granulocyte colony stimulating factor, Autologous Stem Cell Infusion, Melphalan, Cyclophosphamide, Carboplatin, Etoposide · Intervention Types: Drug, Biological, Biological, Drug, Drug, Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Thiotepa
FDA approved
Melphalan
FDA approved
Cyclophosphamide
FDA approved
Carboplatin
FDA approved
Etoposide
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 3 years from first pbsc infusion

Who is running the clinical trial?

Masonic Cancer Center, University of MinnesotaLead Sponsor
259 Previous Clinical Trials
15,823 Total Patients Enrolled
4 Trials studying Neuroblastoma
137 Patients Enrolled for Neuroblastoma
Ashish Gupta, MBBS, MPHPrincipal InvestigatorMasonic Cancer Center, University of Minnesota
3 Previous Clinical Trials
65 Total Patients Enrolled
1 Trials studying Neuroblastoma
20 Patients Enrolled for Neuroblastoma

Eligibility Criteria

Age < 65 · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a diagnosis of neuroblastoma before the age of 30.
You have received chemotherapy for leukemia and have recovered from that chemotherapy.