Combination Vaccine for Neuroblastoma
(CHESAT Trial)
AA
Overseen byAndras A. Heczey, MD
Age: Any Age
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 1 & 2
Waitlist Available
Sponsor: Baylor College of Medicine
No Placebo Group
Trial Summary
What is the purpose of this trial?
This trial tests a new treatment for high-risk neuroblastoma using two types of cancer cell vaccines. One vaccine is modified to release proteins that boost the immune system. The goal is to help the body fight cancer more effectively.
Research Team
AA
Andras A. Heczey, MD
Principal Investigator
Baylor College of Medicine
Eligibility Criteria
This trial is for individuals under 21 years old with high-risk neuroblastoma, who are about to have stem cell rescue after intense chemotherapy. They must not be pregnant, HIV positive, or have received other vaccines or investigational agents in the past six months. Participants should agree to effective birth control during and for six months post-trial.Inclusion Criteria
HIV negative
I was diagnosed before turning 21.
My diagnosis was high-risk neuroblastoma.
See 4 more
Exclusion Criteria
I do not have any severe illnesses or social situations that would stop me from following the study's requirements.
I am not currently on experimental drugs or had cancer vaccines in the last 6 months.
Pregnant
See 1 more
Treatment Details
Interventions
- SNJB-JF-IL2 and SJNB-JF-Lptn + Dose Level 1 SKNLP (Cancer Vaccine)
- SNJB-JF-IL2 and SJNB-JF-Lptn + Dose Level 2 SKNLP (Cancer Vaccine)
Trial OverviewThe study tests the safety and effectiveness of two allogeneic neuroblastoma tumor cell line vaccines combined with IL-2/Lptn secretion on patients with high-risk neuroblastoma undergoing chemotherapy and autologous stem cell rescue as consolidation therapy.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Dose Level 2Experimental Treatment1 Intervention
SNJB-JF-IL2 and SJNB-JF-Lptn + Dose Level 2 SKNLP
Group II: Dose Level 1Experimental Treatment1 Intervention
SNJB-JF-IL2 and SJNB-JF-Lptn + Dose Level 1 SKNLP
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor College of Medicine
Lead Sponsor
Trials
1,044
Recruited
6,031,000+
Center for Cell and Gene Therapy, Baylor College of Medicine
Collaborator
Trials
114
Recruited
2,900+