Ketogenic Diet for Bipolar Disorder
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how a ketogenic diet, high in fats and low in carbohydrates, might aid individuals with bipolar disorder experiencing depression. Researchers aim to determine if this diet can enhance mood and assess its impact on heart and metabolic health. Suitable candidates for this trial have been diagnosed with bipolar disorder, are experiencing depressive symptoms, and are willing to adopt a ketogenic diet. As an unphased study, this trial provides a unique opportunity to explore potential dietary benefits for mood improvement and overall health.
Do I have to stop taking my current medications for the trial?
The trial does not specify if you need to stop taking your current medications. However, it mentions that participants should have stable mood stabilization with certain medications like lithium or atypical antipsychotics, so you might be able to continue those. It's best to discuss your specific medications with the trial team.
What prior data suggests that the ketogenic diet is safe for individuals with bipolar disorder?
Research has shown that the ketogenic diet might be safe for people with bipolar disorder. In one study, most participants who followed the diet entered and stayed in ketosis, where the body uses fat for energy. The side effects were usually mild and manageable. Another study found that people on this diet might feel more satisfied with life and sleep better. Although more research is needed, current evidence suggests that the ketogenic diet could safely help manage symptoms of bipolar disorder.12345
Why are researchers excited about this trial?
Most treatments for bipolar disorder, like mood stabilizers and antipsychotics, focus on balancing neurotransmitters in the brain. The ketogenic diet is unique because it offers a metabolic approach, altering the body's energy source by shifting from carbohydrates to fats. Researchers are excited because this diet might stabilize mood through changes in brain energy metabolism, potentially providing benefits for those who don't respond well to traditional medications. Plus, it offers a non-pharmaceutical option, which could mean fewer side effects compared to conventional treatments.
What evidence suggests that the ketogenic diet might be an effective treatment for bipolar disorder?
Research has shown that a ketogenic diet, which participants in this trial will follow, might help people with bipolar disorder. Some studies suggest that this diet can stabilize the brain by altering its energy use. For instance, a small study found that the keto diet improved severe mental health issues, including bipolar disorder. Another case study reported significant improvement in depression symptoms for someone with bipolar disorder that didn't respond to other treatments. Additionally, higher levels of ketones, produced by this diet, were linked to better mood, increased energy, and reduced anxiety. These findings suggest that a ketogenic diet could be a promising way to manage bipolar symptoms.14567
Who Is on the Research Team?
Kyla M. Lara-Breitinger, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults aged 18-50 with bipolar I or II disorder, or BP schizoaffective Disorder, who are stable medically and willing to switch to a high-fat, low-carb diet. They must not be pregnant, have negative drug screens (except prescribed meds), use birth control if sexually active, and have mild depression at least. Exclusions include severe medical conditions like renal failure, psychosis, substance abuse disorders; current involuntary hospitalization; certain dietary restrictions; and no access to smartphone/internet.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants follow a ketogenic diet to assess clinical and cardiometabolic correlates in bipolar depression
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ketogenic Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor