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What is Esmolol Hydrochloride
EsmololThe Generic name of this drug
Treatment SummaryEsmolol, also known by the brand name Brevibloc, is a medication that slows down the heart rate and reduces the force of heart contractions. It works by blocking the action of two chemicals, epinephrine and norepinephrine, and it has a fast onset but short duration of action. It is mostly used in medical settings to treat rapid heart rates and is generally safe and effective at recommended doses.
Esmolol Hydrochlorideis the brand name
Esmolol Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esmolol Hydrochloride
Esmolol
1986
49
Effectiveness
How Esmolol Hydrochloride works in the bodyEsmolol is a type of drug called a beta-blocker. It works by blocking the effects of certain chemical messengers in the body. This decreases the activity of the heart, which can be useful in treating certain irregular heartbeats. Esmolol is more selective than some other beta-blockers, meaning that it mainly affects the heart and not other organs. At normal doses, it does not cause any additional stimulation of the heart. This makes it useful for treating arrhythmias, which are abnormal heart rates.
When to interrupt dosage
The recommended dosage of Esmolol Hydrochloride is contingent upon the determined condition, such as Supraventricular Tachycardia (SVT), heart rate irregularity and peri-operative period. The dosage depends upon the administration method (e.g. Liquid - Intravenous or Liquid) provided in the table underneath.Condition
Dosage
Administration
Supraventricular Tachycardia (SVT)
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Atrial Fibrillation
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
peri-operative period
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Sinus Tachycardia
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Rapid Heartbeat
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
abnormal ventricular rate
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Hypertensive disease
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
heart rate abnormal
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Warnings
Esmolol Hydrochloride ContraindicationsCondition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Sinus Bradycardia
Do Not Combine
Heart Block
Do Not Combine
Heart failure
Do Not Combine
Common Esmolol Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Esmolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Esmolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Esmolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Esmolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Esmolol.
Esmolol Hydrochloride Toxicity & Overdose RiskOverdosing on Digoxin can lead to serious conditions such as cardiac arrest, slow heart rate, low blood pressure, and loss of consciousness.
Esmolol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Esmolol Hydrochloride?
Currently, 243 active clinical trials are examining the potential of Esmolol Hydrochloride to regulate aberrant ventricular rate, Flutter, Atrial arrhythmia and peri-operative period.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Supraventricular Tachycardia (SVT)
1 Actively Recruiting
Not Applicable
abnormal ventricular rate
0 Actively Recruiting
peri-operative period
0 Actively Recruiting
heart rate abnormal
0 Actively Recruiting
Sinus Tachycardia
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Rapid Heartbeat
66 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4
Esmolol Hydrochloride Reviews: What are patients saying about Esmolol Hydrochloride?
4.3Patient Review
6/4/2009 This drug, in combination with atrial lead wire placement, saved my father's life. He had a massive AMI on 5-10-09 and was experiencing recurrent VT and VFib afterwards. The medication has been working great so far; as of 06-03-09, he is doing much better.
Patient Q&A Section about esmolol hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is esmolol used for?
"Esmolol is used to control rapid heartbeats or abnormal heart rhythms. This medicine is also used to treat fast heartbeat and high blood pressure during surgery, after surgery, or during other medical procedures."
Answered by AI
What does esmolol do to the heart?
"This medicine is a beta-blocker. It affects the response to nerve impulses in certain parts of the body, such as the heart. As a result, the heart beats slower and decreases the blood pressure."
Answered by AI
What drug class is esmolol?
"Esmolol is a short-acting, cardio-selective beta-blocker that works by antagonizing the beta-1-adrenergic receptors primarily in the myocytes."
Answered by AI
How long does it take esmolol to work?
"If no loading doses are given, it will take about 30 minutes for the effects of esmolol to reach a steady state."
Answered by AI