Esmolol Hydrochloride

Atrial Fibrillation, Rapid Heartbeat, Sinus Tachycardia + 5 more
Treatment
20 Active Studies for Esmolol Hydrochloride

What is Esmolol Hydrochloride

EsmololThe Generic name of this drug
Treatment SummaryEsmolol, also known by the brand name Brevibloc, is a medication that slows down the heart rate and reduces the force of heart contractions. It works by blocking the action of two chemicals, epinephrine and norepinephrine, and it has a fast onset but short duration of action. It is mostly used in medical settings to treat rapid heart rates and is generally safe and effective at recommended doses.
Esmolol Hydrochlorideis the brand name
Esmolol Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esmolol Hydrochloride
Esmolol
1986
49

Effectiveness

How Esmolol Hydrochloride works in the bodyEsmolol is a type of drug called a beta-blocker. It works by blocking the effects of certain chemical messengers in the body. This decreases the activity of the heart, which can be useful in treating certain irregular heartbeats. Esmolol is more selective than some other beta-blockers, meaning that it mainly affects the heart and not other organs. At normal doses, it does not cause any additional stimulation of the heart. This makes it useful for treating arrhythmias, which are abnormal heart rates.

When to interrupt dosage

The recommended dosage of Esmolol Hydrochloride is contingent upon the determined condition, such as Supraventricular Tachycardia (SVT), heart rate irregularity and peri-operative period. The dosage depends upon the administration method (e.g. Liquid - Intravenous or Liquid) provided in the table underneath.
Condition
Dosage
Administration
Rapid Heartbeat
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Sinus Tachycardia
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Hypertensive disease
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Atrial Fibrillation
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Tachycardia, Supraventricular
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Tachycardia, Ventricular
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
peri-operative period
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Arrhythmias, Cardiac
10.0 mg/mL, , 20.0 mg/mL, 250.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous

Warnings

Esmolol Hydrochloride Contraindications
Condition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Sinus Bradycardia
Do Not Combine
Heart Block
Do Not Combine
Heart failure
Do Not Combine
There are 20 known major drug interactions with Esmolol Hydrochloride.
Common Esmolol Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Esmolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Esmolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Esmolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Esmolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Esmolol.
Esmolol Hydrochloride Toxicity & Overdose RiskOverdosing on Digoxin can lead to serious conditions such as cardiac arrest, slow heart rate, low blood pressure, and loss of consciousness.
image of a doctor in a lab doing drug, clinical research

Esmolol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Esmolol Hydrochloride?

Currently, 243 active clinical trials are examining the potential of Esmolol Hydrochloride to regulate aberrant ventricular rate, Flutter, Atrial arrhythmia and peri-operative period.
Condition
Clinical Trials
Trial Phases
Sinus Tachycardia
0 Actively Recruiting
Tachycardia, Ventricular
0 Actively Recruiting
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Arrhythmias, Cardiac
0 Actively Recruiting
peri-operative period
0 Actively Recruiting
Tachycardia, Supraventricular
0 Actively Recruiting
Rapid Heartbeat
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Esmolol Hydrochloride Reviews: What are patients saying about Esmolol Hydrochloride?

4.3Patient Review
6/4/2009
Esmolol Hydrochloride for Having a Rapid Heart Action - Supraventricular Tachycardia
This drug, in combination with atrial lead wire placement, saved my father's life. He had a massive AMI on 5-10-09 and was experiencing recurrent VT and VFib afterwards. The medication has been working great so far; as of 06-03-09, he is doing much better.

Patient Q&A Section about esmolol hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is esmolol used for?

"Esmolol is used to control rapid heartbeats or abnormal heart rhythms. This medicine is also used to treat fast heartbeat and high blood pressure during surgery, after surgery, or during other medical procedures."

Answered by AI

What does esmolol do to the heart?

"This medicine is a beta-blocker. It affects the response to nerve impulses in certain parts of the body, such as the heart. As a result, the heart beats slower and decreases the blood pressure."

Answered by AI

What drug class is esmolol?

"Esmolol is a short-acting, cardio-selective beta-blocker that works by antagonizing the beta-1-adrenergic receptors primarily in the myocytes."

Answered by AI

How long does it take esmolol to work?

"If no loading doses are given, it will take about 30 minutes for the effects of esmolol to reach a steady state."

Answered by AI

Clinical Trials for Esmolol Hydrochloride

Have you considered Esmolol Hydrochloride clinical trials? We made a collection of clinical trials featuring Esmolol Hydrochloride, we think they might fit your search criteria.
Have you considered Esmolol Hydrochloride clinical trials? We made a collection of clinical trials featuring Esmolol Hydrochloride, we think they might fit your search criteria.
Have you considered Esmolol Hydrochloride clinical trials? We made a collection of clinical trials featuring Esmolol Hydrochloride, we think they might fit your search criteria.
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